Microbial fuel cell (MFC) technology can be employed in order to add value to the metabolic products of acetogenesis fermentation after H 2 production. Considering the total conversion of glucose into acetic acid as the only bioproduct, only 1/3 of the energy available is converted in H 2 from a thermodynamic point of view (Chap. 5). Furthermore, in practical terms, the energy necessary to carry out the pretreatments must be considered as energy used to perform the energy balance, in order to render the organic contents accessible to microorganisms (Chap. 9). Nevertheless, the aim of this book is to focus on anaerobic technology and its energy sustainability; the conversion of H 2 production residues, such as VFA, into additional H 2 or CH 4 or electricity needs to be investigated. Even if the MFC technology is in its infancy, it deserves a very close attention for the possibility of generating electrical energy or additional H 2 . The present chapter is devoted to explore the potential of MFC technology.