The Potentiation of Tetanus Toxin by Broth and Serum

Traub, Frederick B.; Hollander, Alvin; Friedemann, Ulrich

doi:10.1128/jb.52.2.169-177.1946

Cited by 5 publications

(1 citation statement)

References 11 publications

(3 reference statements)

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“…Such comparative studies of impure and pure toxin from different strains might also contribute clues for understanding of the potentiation phenomenon in tetanus. 273 Purification and characterization of toxin. A number of methods of purification result in isolation of toxin considered homogeneous by electrophoretic and sedimentation analyses.…”

Section: Tetanal Toxinmentioning

confidence: 99%

The botulinal, tetanal, and enterostaphylococcal toxins: A review

Lamanna¹,

Cj²

1967

Clin Pharma and Therapeutics

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It is our wish to consider the current status of knowledge and to stimulate awareness of the problems and opportunities existing for future studies of the nature and actions of the botulinal, tetanal, and enterostaphylococcal toxins. Increasing knowledge makes such a review timely. In the light of the selective actions of botulinal and tetanal toxins on autonomic and central nervous system interneuronal mechanisms, it is remarkable that one finds no references to these very useful agents in the outstanding texts and reference volumes in neurophysiology and pharmacology. Successful methods of purification now make it possible to employ these toxins as specific reprodUCible and selective reagents or aids in the study of physioReceived for publication Oct. 5, 1966. 286logical and pharmacological questions, a potential that has not been exploited maximally.It is logical to consider these three exotoxins of gram positive bacteria in a single paper because in common they have been proven to be neurotoxic simple proteins. Our attention will not be focused on the purely bacteriological questions of the origin of these toxins in the bacterial economy and environmental factors influencing their production and occurrence in clinical illness. Nor will we consider the clinical problem of tetanus and botulism in medical and veterinary practice, and the occurrence of botulism in wildlife. Reviews including subject matter we have not covered are available. 90 , 93, 114, 115, 128, 135, 154, 156, 177,249,307,308 We will consider primarily the nature and actions of the toxins.

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Section: Tetanal Toxinmentioning

confidence: 99%