The potential utility of high-intensity ultrasound to treat osteoarthritis

Abstract

Osteoarthritis (OA) is a widespread musculoskeletal disease that reduces quality of life and for which there is no cure. The treatment of OA is challenging since cartilage impedes the local and systemic delivery of therapeutic compounds (TCs). This review identifies high-intensity ultrasound (HIU) as a non-contact technique to modify articular cartilage and subchondral bone. HIU enables new approaches to overcome challenges associated with drug delivery to cartilage and new non-invasive approaches for the treatment of joint disease. Specifically, HIU has the potential to facilitate targeted drug delivery and release deep within cartilage, to repair soft tissue damage, and to physically alter tissue structures including cartilage and bone. The localized, non-invasive ultrasonic delivery of TCs to articular cartilage and subchondral bone appears to be a promising technique in the immediate future.

Medical rehabilitation in the combination treatment of rheumatic diseases: a review

“…д.). Считается, что УЗТ способствует улучшению микроциркуляции, разрешению мышечного напряжения, уменьшению чувствительности болевых рецепторов и повышению скорости репаративных процессов [44].…”

Inorganic/Organic Multilayer Capsule Composition for Improved Functionality and External Triggering

“…It leads to the highest impact of ultrasound on the hydrophobic modified surface in comprising with hydrophilic surface. [132] Nowadays, A number of new approaches for in vivo visualization and treatment using ultrasound such as HIFU [133][134][135] and PA imaging [136,137] are rapidly growing. [129] The hydrophobic surfaces were made using imprinting method, [128] but recently an original approach was demonstrated using consequently adsorption hydrophilic PE molecules and hydrophobic nanoparticles.…”

“…[131] The third approach focuses on the resonance phenomenon that was suggested during last year. [132] Nowadays, A number of new approaches for in vivo visualization and treatment using ultrasound such as HIFU [133][134][135] and PA imaging [136,137] are rapidly growing. HIFU is intensively used now as noninvasive method for cancer therapy.…”

Localized delivery of compounds into articular cartilage by using high-intensity focused ultrasound

“…When the ultrasound energy is absorbed into liquid, acoustic streaming may form 7,10 . Importantly, HIU can palpate a material or translate particles and gas voids non-destructively 6,11,12 from a distance, e.g . through the skin within the body.…”