The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers

Hermansyah, Dedy; Zulhendri, Felix; Perera, Conrad O.; Firsty, Naufal Nandita; Chandrasekaran, Kavita; Abdulah, Rizky; Herman, Herry; Lesmana, Ronny

doi:10.1177/15347354221096868

Cited by 11 publications

(5 citation statements)

References 102 publications

(78 reference statements)

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“…Therefore, the use of anti-inflammatory compounds has been linked to lower the risk of cancers, namely esophageal, stomach, liver, and pancreatic cancer [ 38 ]. Propolis, as a natural product, with its anti-inflammatory properties could potentially play a role in alleviating cancer progression and its associated symptoms [ 3 ].…”

Section: Resultsmentioning

confidence: 99%

“…Historical records show that ancient Egyptians, Greeks, Persians, Romans, Indians, Mayans, and Australian Aborigines independently developed the therapeutic use of propolis. The more recent scientific research demonstrates that the therapeutic properties of propolis are due to its content of plant secondary metabolites such as phenolics and terpenoids [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Update on the Anti-Inflammatory Activities of Propolis

et al. 2022

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In recent years, research has demonstrated the efficacy propolis as a potential raw material for pharmaceuticals and nutraceuticals. There is limited report detailing the mechanisms of action of propolis and its bioactive compounds in relation to their anti-inflammatory properties. Thus, the aim of the present review is to examine the latest experimental evidence (2017–2022) regarding the anti-inflammatory properties of propolis. A systematic scoping review methodology was implemented. After applying the exclusion criteria, a total of 166 research publications were identified and retrieved from Scopus, Web of Science, and Pubmed. Several key themes related to the anti-inflammatory properties of propolis were subsequently identified, namely in relation to cancers, oral health, metabolic syndrome, organ toxicity and inflammation, immune system, wound healing, and pathogenic infections. Based on the latest experimental evidence, propolis is demonstrated to possess various mechanisms of action in modulating inflammation towards the regulatory balance and anti-inflammatory environment. In general, we summarize that propolis acts as an anti-inflammatory substance by inhibiting and downregulating TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, and their associated pro-inflammatory cytokines such as IL-1β, IL-6, IFN-γ, and TNF-α. Propolis also reduces the migration of immune cells such as macrophages and neutrophils, possibly by downregulating the chemokines CXCL9 and CXCL10.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Update on the Anti-Inflammatory Activities of Propolis

et al. 2022

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“…Hermansyah et al., (2022) [19] describe four human clinical trials that demonstrated the use of propolis in alleviating side effects of chemotherapy and radiotherapy while increasing the quality of life of breast cancer patients, with minimal adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] Several bioactive compounds present in propolis, e. g., artepillin C, inhibit the migration and invasion of cells of some types of cancer. [18] Hermansyah et al, (2022) [19] describe four human clinical trials that demonstrated the use of propolis in alleviating side effects of chemotherapy and radiotherapy while increasing the quality of life of breast cancer patients, with minimal adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Physical and Chemical Properties of Green and Brown Brazilian Propolis Collected in Minas Gerais, Brazil

Messias

Lopes

Oliveira

et al. 2023

Chemistry & Biodiversity

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Among the 13 types of propolis classified in Brazil according to their physicochemical properties, green propolis and brown propolis are the most commonly found and used. In this work, a comparison of the physicochemical properties of green and brown propolis produced in Minas Gerais, Brazil was performed according to the methodology established by the Brazilian legislation. And, the content of 9 bioactive compounds in the samples was determined by RP‐HPLC. GrProp showed a higher content of pinocembrin, artepillin C and baccharin, and a higher quantity of total flavonoids, in comparison with BrwProp. The mechanical mass content in both types of propolis was above the limit established by legislation. However, the other physicochemical parameters were within the limits. The chemical composition, especially the flavonoid content and the free radical (DPPH) scavenger property confer to both types of propolis a promising pharmacological activity.

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“…Propolis is a resinous beehive product that is collected by bees from plant exudates and is used to protect and maintain hive homeostasis [ 1 , 2 ]. Propolis has been used by humans therapeutically to treat inflammation and infectious diseases [ 3 , 4 , 5 , 6 , 7 , 8 ]. Numerous studies have revealed a range of biological activities of propolis, including antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, and antioxidant activities [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils from Populus balsamifera Buds and Propolis

Schepetkin

Özek

et al. 2022

Plants

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Propolis is a resinous mixture of substances collected and processed from various botanical sources by honeybees. Black poplar (Populus balsamifera L.) buds are one of the primary sources of propolis. Despite their reported therapeutic properties, little is known about the innate immunomodulatory activity of essential oils from P. balsamifera and propolis. In the present studies, essential oils were isolated from the buds of P. balsamifera and propolis collected in Montana. The main components of the essential oil from P. balsamifera were E-nerolidol (64.0%), 1,8-cineole (10.8%), benzyl benzoate (3.7%), α-terpinyl acetate (2.7%), α-pinene (1.8%), o-methyl anisol (1.8%), salicylaldehyde (1.8%), and benzyl salicylate (1.6%). Likewise, the essential oil from propolis was enriched with E-nerolidol (14.4%), cabreuva oxide-VI (7.9%), α-bisabolol (7.1%), benzyl benzoate (6.1%), β-eudesmol (3.6%), T-cadinol (3.1%), 2-methyl-3-buten-2-ol (3.1%), α-eudesmol (3.0%), fokienol (2.2%), nerolidol oxide derivative (1.9%), decanal (1.8%), 3-butenyl benzene (1.5%), 1,4-dihydronaphthalene (1.5%), selina-4,11-diene (1.5%), α-cadinol (1.5%), linalool (1.4%), γ-cadinene (1.4%), 2-phenylethyl-2-methyl butyrate (1.4%), 2-methyl-2-butenol (1.3%), octanal (1.1%), benzylacetone (1.1%), and eremoligenol (1.1%). A comparison between P. balsamifera and propolis essential oils demonstrated that 22 compounds were found in both essential oil samples. Both were enriched in E-nerolidol and its derivatives, including cabreuva oxide VI and nerolidol oxides. P. balsamifera and propolis essential oils and pure nerolidol activated Ca2+ influx in human neutrophils. Since these treatments activated neutrophils, the essential oil samples were also evaluated for their ability to down-regulate the neutrophil responses to subsequent agonist activation. Indeed, treatment with P. balsamifera and propolis essential oils inhibited subsequent activation of these cells by the N-formyl peptide receptor 1 (FPR1) agonist fMLF and the FPR2 agonist WKYMVM. Likewise, nerolidol inhibited human neutrophil activation induced by fMLF (IC50 = 4.0 μM) and WKYMVM (IC50 = 3.7 μM). Pretreatment with the essential oils and nerolidol also inhibited human neutrophil chemotaxis induced by fMLF, again suggesting that these treatments down-regulated human neutrophil responses to inflammatory chemoattractants. Finally, reverse pharmacophore mapping predicted several potential kinase targets for nerolidol. Thus, our studies have identified nerolidol as a potential anti-inflammatory modulator of human neutrophils.

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The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers

Cited by 11 publications

References 102 publications

Recent Update on the Anti-Inflammatory Activities of Propolis

Recent Update on the Anti-Inflammatory Activities of Propolis

Comparison of Physical and Chemical Properties of Green and Brown Brazilian Propolis Collected in Minas Gerais, Brazil

Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils from Populus balsamifera Buds and Propolis

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