The Potential Use of Persian Herbal Medicines Against COVID-19 Through Angiotensin-Converting Enzyme 2

Heidary, Fatemeh; Varnaseri, Mehran; Gharebaghi, Reza

doi:10.5812/archcid.102838

Cited by 14 publications

(18 citation statements)

References 12 publications

(12 reference statements)

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“…They are Radix et Rhizoma Rhei, Radix Polygoni multiflori , Caulis Polygoni multiflori , Cerasus avium (L.) Moench, Alcea digitata (Boiss.) Alef, Rubia tinctorum L., Citrus aurantium L., Berberis integerrima Bge, Peganum harmala L. and Allium sativum L. [ 78 , 91 ].…”

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

“…According to Ziai et al’s 2009 in vitro study, this plant showed very good potential to inhibit or completely block the ACE-2 receptor [ 94 ]. Subsequently, Heidary et al, 2020 recently suggested that this plant has good potency against SARS-CoV-2 and must be used for the treatment of its infection [ 91 ].…”

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

“…According to one published report [ 96 ], A. digitata is known to have good potential to block or inhibit the ACE-2 receptor. Recently, Heidary et al, 2020 suggested that A. digitata can possibly show good inhibitory effects against SARS-CoV-2 infection [ 91 ].…”

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

“…However, C. aurantium fruit extract is manly used for the treatment of anxiety, lung related diseases, obesity, gastrointestinal disorders and prostate cancer [ 249 , 251 ], buts has potential to inhibit or block the ACE-2 receptor. Some in vitro studies have shown its efficacy in inhibiting ACE-2 receptors [ 91 ].…”

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

“…Furthermore, the root of R. tinctorum contains red color due to the presence of anthraquinone, alizarin and pseudopurpurin, which is also used for dyeing purposes [ 103 ]. On the other hand, R. tinctorum has shown potential to inhibit or block the ACE-2 receptor [ 91 ]. in vitro studies revealed the efficient use of R. tinctorum to inhibit ACE-2 receptors [ 91 ].…”

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

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Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. In this review, we have consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this review will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.

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Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

Section: Known Medicinal Plants Acting On Ace-2 Receptormentioning

confidence: 99%

See 3 more Smart Citations

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis

Ziaei,

Alimohammadi‐Kamalabadi,

Hasani

et al. 2023

Food Science & Nutrition

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Coronavirus disease (COVID‐19) affects both the respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, as potential treatment methods to help patients combat COVID‐19. The aim of this systematic review and meta‐analysis is to give a comprehensive overview of the impact of quercetin supplementation on inflammatory factors, hospital admission, and mortality of patients with COVID‐19. The search has been conducted on PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library using relevant keywords until August 25, 2023. We included randomized controlled trials (RCTs) comparing COVID‐19 patients who received quercetin supplementation versus controls. We included five studies summarizing the evidence in 544 patients. Meta‐analysis showed that quercetin administration significantly reduced LDH activity (standard mean difference (SMD): −0.42, 95% CI: −0.82, −0.02, I2 = 48.86%), decreased the risk of hospital admission by 70% (RR: 0.30, 95% CI: 0.14, 0.62, I2 = 00.00%), ICU admission by 73% (RR: 0.27, 95% CI: 0.09, 0.78, I2 = 20.66%), and mortality by 82% (RR: 0.18, 95% CI: 0.03, 0.98, I2 = 00.00%). No significant changes in CRP, D‐dimmer, and ferritin were found between groups. Quercetin was found to significantly reduce LDH levels and decrease the risk of hospital and ICU admission and mortality in patients with COVID‐19 infection.

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Medicinal Plants as COVID-19 Remedy

Zafar

Perveen

Iqbal

et al. 2021

Alternative Medicine Interventions for COVID-19

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The Potential Use of Persian Herbal Medicines Against COVID-19 Through Angiotensin-Converting Enzyme 2

Cited by 14 publications

References 12 publications

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis

Medicinal Plants as COVID-19 Remedy

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