The Potential Use of Indigobush (Amorpha fruticosa L.) as Natural Resource of Biologically Active Compounds

Abstract

Background and Purpose: Recent research indicates that a weed like Indigobush (Amorpha fruticosa L.) gives great opportunities for its commercialization through a rich spectrum of its beneficial biological features with possible use in the forestry and biotechnology field. Therefore, in this study we wanted to explore some of potential application of Indigobush extract, as a source of biologically active compounds, for animal cell culturing as well as green corrosion inhibitors. Materials and Methods: The effect of ethanol extract of Indigobush seeds was studied on human tumor cell lines (HeLa and MCF-7) and cell viability was determined by WST-1 method after 72 hours of treatment with 6 different extract concentrations (0.5-10 mg•mL-1). The inhibition effect of Indigobush seeds extract on the corrosion of aluminum in 0.5 M hydrochloric acid solution was investigated by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) methods. Results: Results showed that the addition of Indigobush extract had a stimulatory effect on MCF-7 cells growth at the concentrations >1 mg•mL-1 while the same effect on HeLa cells was observed only

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

“…Considering IC 50 values, according to criteria of American National Cancer Institute (NCI) for cytotoxity (IC 50 < 30 μg/mL) (Suffness and Pezzuto 1990), the investigated plants did not show significant cytotoxic effects on these cell lines. The cytotoxic effects of RpE and AfE were investigated by other author on different cell lines (Frédérich et al 2009), and our data correlate with no significant cytotoxic activity of AfE, observed in Jakovljević et al (2015). Although RpE and AfE showed no significant cytotoxic activity, they still have potential application as supplements in anti-tumor therapy.…”

“…Antispasmodic, diuretic and anticancer effect of R. pseudoacacia (due bensaldehyde isolated from flowers of this plant) were confirmed (Duke and Wain 1981). Amorpha fruticosa shows anticancer, antimicrobial and antioxidant activity (Jakovljević et al 2015).…”