The Potential Use of Dimethyltryptamine against Ischemia-reperfusion Injury of the Brain
Kovacs Attila,
Mathe Anna,
Frecska Ede
Abstract:Ischemia-Reperfusion Injury (IRI) is the outcome of two intertwined pathological processes resulting from the shortage of blood flow to tissues and the subsequent restoration of circulation to a previously ischemic area. IRI (sometimes just one side of the dyad) remains one of the most challenging problems in several branches of emergency medicine. Mitochondrial and endoplasmic reticulum dysfunction is a crucial pathological factor involved in the development of IRI. The sigma-1 receptor (Sig1-R) is an intrac… Show more
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