The potential role of vitamin D binding protein in kidney disease: a comprehensive review

Delanghe, Joris R.; Delrue, Charlotte; Speeckaert, Reinhart; Speeckaert, Marijn M.

doi:10.1080/17843286.2023.2301278

Cited by 2 publications

(3 citation statements)

References 81 publications

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“…PLAT (plasminogen activator, tissue type) [325] and ALB (albumin) [326] might be involved in the occurrence and development of hypertension. BMI1 [327], AMH (anti-Mullerian hormone) [328], E2F1 [329], PF4 [330], VASH2 [331], GRIN1 [332], CYP11B2 [333], COMP (cartilage oligomeric matrix protein) [334], DES (desmin) [335], ANGPTL3 [336], CYP3A5 [337], DPEP1 [338], LRP2 [339], AGXT2 [340], FABP1 [341], SLC22A12 [342], CUBN (cubilin) [343], MIOX (myo-inositol oxygenase) [344], ARG2 [345], KHK (ketohexokinase) [346], CYP2C8 [347], SLC2A9 [348], GC (GC vitamin D binding protein) [349], VNN1 [350], NOX4 [351], EPHX2 [352], AKR1C3 [353], NR4A3 [354], PFKFB2 [355], SLC22A6 [356], F11 [357], SLC22A2 [358], AQP2 [171], EGF (epidermal growth factor) [359], KNG1 [360], SERPINA5 [361], KL (klotho) [362], ACE2 [363], NPNT (nephronectin) [364], SLC47A1 [358], MGAM (maltase-glucoamylase) [365], AQP3 [366], AZGP1 [367], GALNT3 [368], DPP4 [369], STC1 [370], ABCB1 [371], ERRFI1 [372], TREH (trehalase) [373], MANBA (mannosidase beta) [374], ERBB4 [375], VCAM1 [376] and ALB (albumin) [377] might play an important role in the pathophysiology of AKI. BMI1 [378], IGF2 [379], PRKCB (protein kinase C beta) [380], CCL5 [381], E2F1 [382], PF4 [111], CYP11B2 [383], WNT3A [384], COMP (cartilage oligomeric matrix protein) [385], DES (desmin) [335], ANGPTL3 [386], CYP3A5 [387], LRP2 [388], PAH (phenylalanine hydroxylase) [389], HMGCS2 [390]...…”

Section: Discussionmentioning

confidence: 99%

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Acute kidney injury (AKI) is a type of renal disease occurs frequently in hospitalized patients, which may cause abnormal renal function and structure with increase in serum creatinine level with or without reduced urine output. With the incidence of AKI is increasing. However, the molecular mechanisms of AKI have not been elucidated. It is significant to further explore the molecular mechanisms of AKI. We downloaded the GSE139061 next generation sequencing (NGS) dataset from the Gene Expression Omnibus (GEO) database. Limma R bioconductor package was used to screen the differentially expressed genes (DEGs). Then, the enrichment analysis of DEGs in Gene Ontology (GO) function and REACTOME pathways was analyzed by g:Profiler. Next, the protein-protein interaction (PPI) network and modules was constructed and analyzed, and the hub genes were identified. Next, the miRNA-hub gene regulatory network and TF-hub gene regulatory network were built. We also validated the identified hub genes via receiver operating characteristic (ROC) curve analysis. Overall, 956 DEGs were identified, including 478 up regulated and 478 down regulated genes. The enrichment functions and pathways of DEGs involve primary metabolic process, small molecule metabolic process, striated muscle contraction and metabolism. Topological analysis of the PPI network and module revealed that hub genes, including PPP1CC, RPS2, MDFI, BMI1, RPL23A, VCAM1, ALB, SNCA, DPP4 and RPL26L1, might be involved in the development of AKI. miRNA-hub gene and TF-hub gene regulatory networks revealed that miRNAs and TFs including hsa-mir-510-3p, hsa-mir-6086 and mir-146a-5p, MAX and PAX2, might be involved in the development of AKI. Various known and newtherapeutic targets were obtained via network analysis. The results of the current investigation might be beneficial for the diagnosis and treatment of AKI.

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Section: Discussionmentioning

confidence: 99%

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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“…Certain DBP alleles have been associated with weakened immune response and elevated risk of type 1 diabetes [ 35 ]. This is crucial in the setting of type 1 diabetes mellitus, as the disease progresses due in large part to immunological modulation [ 36 ]. Asp/Glu and Glu/Glu genotype frequencies were considerably higher in diabetic participants with detectable IA-2 antibodies [ 37 ].…”

Section: Dbp and Chronic Disease Risk In Childrenmentioning

confidence: 99%

“…The main causes of CKD in children include congenital anomalies of the kidney and urinary tract (CAKUT), glomerular diseases, hereditary and genetic disorders, systemic diseases, and tubulointerstitial diseases. The significance of DBP in kidney diseases is highlighted by its several functions in immunological regulation and vitamin D metabolism [ 36 ]. Children with CKD may have low levels of vitamin D due to limited sun exposure, reduced dietary intake, loss during dialysis, and inadequate renal conversion to the active form.…”

Section: Dbp and Chronic Disease Risk In Childrenmentioning

confidence: 99%

Investigating Vitamin D-Binding Protein’s Role in Childhood Health and Development

Delrue,

Speeckaert,

Delanghe

et al. 2024

IJMS

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Vitamin D-binding protein (DBP), also known as Gc-globulin, is a protein that affects several physiological processes, including the transport and regulation of vitamin D metabolites. Genetic polymorphisms in the DBP gene have a significant impact on vitamin D levels and may have implications for disease risk. DBP polymorphisms are linked to differential immune responses, which could influence the onset of juvenile diseases. This narrative review examines the various roles of DBP, with a focus on bone health, immunological regulation, and lipid metabolism in children. Chronic disorders affected by DBP polymorphisms include bone abnormalities, autoimmune diseases, cardiovascular issues, childhood asthma, allergies, cystic fibrosis, acute liver failure, celiac disease, inflammatory bowel disease, and chronic kidney disease. Future research should focus on identifying the processes that underpin the many roles that DBP plays and developing customized therapeutics to improve health outcomes in the juvenile population.

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The potential role of vitamin D binding protein in kidney disease: a comprehensive review

Cited by 2 publications

References 81 publications

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Investigating Vitamin D-Binding Protein’s Role in Childhood Health and Development

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