The Potential Role of Serum Tau Protein (MAPT), Neuronal Cell Adhesion Molecule (NrCAM) and Neprilysin (NEP) in Neurodegenerative Disorders Development in Psoriasis—Preliminary Results

Abstract

Psoriasis is one of the most common dermatoses, which shortens patients’ lives because of the wide comorbidity. However, little is known about its association with neurodegenerative diseases (NDs). We aimed to investigate whether psoriatics are at increased risk of NDs. Sixty patients with plaque-type psoriasis were enrolled into the study. Serum concentrations of tau protein (MAPT), neuronal cell adhesion molecule (NrCAM) and neprilysin (NEP), which are NDs biomarkers and have been hardly studied in psoriasis before, were measured before and after 12 weeks of treatment with acitretin or methotrexate. NrCAM and NEP concentrations were significantly lower in patients than controls, whereas MAPT higher (all p < 0.05). There was no association between these markers and psoriasis severity, BMI or disease duration. After the treatment the concentration of NrCAM and NEP significantly increased and MAPT decreased (p < 0.001, p < 0.05, p < 0.01, respectively). Methotrexate had significant influence on the concentrations of all markers, hence it seems to have neuroprotective properties. Psoriasis severity and duration do not seem to affect the risk of neurodegenerative process. Our results suggest that NDs could be considered as another comorbidity of psoriasis and that further research are needed in order to establish their definite association.

Network Analysis Uncovers Gene-Regulatory Intersections Linking Juvenile Idiopathic Arthritis to Blood Cancers and Other Autoimmune Diseases

“…Interestingly, some of these genes (e.g. HLA-C, HLA-B, TAP2, MAPT, and NOTCH4) have been previously linked to the pathogenesis of psoriasis [88][89][90][91] . We propose that the protein-protein interactions we identi ed contribute to a common pathway disruption, potentially leading to psoriatic symptoms in a subset of JIA patients -a condition referred to as juvenile psoriatic arthritis.…”

Association Between Parkinson’s Disease and Psoriasis: A Scoping Review

“…In Canada, teledermatology (TD) offers a promising solution for enhancing dermatological care in rural and remote communities. [1][2][3] There are noted discrepancies in rural and remote geographical access to dermatological care that highlight a severe and urgent inequity in Canada. Additionally, Indigenous peoples are more likely to be in rural and remote areas compared to the general population, adding to further inequity.…”

“…1 However, conflicting findings exist, with some studies finding weak or no association. 2,3 As such, the relationship between prevalence and disease progression remains controversial. Notably, treatment may influence this relationship as systemic therapy for psoriasis has been found to reduce PD risk.…”

“…4 Similarly, there is not currently a consensus on the physiological connection between PD and psoriasis, however there are several pathogenic links between the diseases, including inflammation pathways, oxidative stress, metabolic disorders, and genetic factors. 3 Several studies have pointed to proinflammatory mediators and various inflammatory pathways as a potential connection between PD and psoriasis. It was found that patients with chronic autoimmune disease have an increased risk of developing neurodegenerative diseases, including PD.…”