The potential role of resistin in atherogenesis

Burnett, Mary Susan; Lee, Cheol W.; Kinnaird, Tim; Stabile, Eugenio; Durrani, Sarfraz; Dullum, Mercedes K.C.; Devaney, Joseph M.; Fishman, Craig; Stamou, Sotiris C.; Caños, Daniel; Zbinden, Stephan; Clavijo, Leonardo; Jang, Gwang Cheon; Andrews, James A.; Zhu, Jianhui; Epstein, Stephen E.

doi:10.1016/j.atherosclerosis.2005.02.014

Cited by 211 publications

(174 citation statements)

References 23 publications

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“…Resistin has been reported to contribute to the worsening of ischemia/reperfusion injury in isolated rat heart preparations [39] and to be associated with high risk in patients with congestive heart failure [40]. In addition, elevated resistin levels correlated with endothelial dysfunction [41] and with the development of atherosclerosis in mice and in patients with premature coronary artery disease [42]. Our results, therefore, further strengthen the hypothesis that resistin is an important modulator of cardiovascular function.…”

Section: Discussionsupporting

confidence: 83%

Role of resistin in cardiac contractility and hypertrophy

Kim

Satoh

et al. 2008

Journal of Molecular and Cellular Cardiology

139

120

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Cardiovascular sequelae including diabetic cardiomyopathy constitute the major cause of death in diabetic patients. Although several factors may contribute to the development of this cardiomyopathy, the underlying molecular/cellular mechanisms leading to cardiac dysfunction are still partially understood. Recently, a novel paradigm for the role of the adipocytokine resistin in diabetes has emerged. Resistin has been proposed to be a link between obesity, insulin resistance and diabetes. Using microarray analysis, we have recently found that cardiomyocytes isolated from type 2 diabetic hearts express high levels of resistin. However, the function of resistin with respect to cardiac function is unknown. In this study we show that resistin is not only expressed in the heart, but also promotes cardiac hypertrophy. Adenovirus-mediated overexpression of resistin in cultured neonatal rat ventricular myocytes (NRVM) significantly increased sarcomere organization and cell size, increased protein synthesis and increased the expression of atrial natriuretic factor and β-myosin heavy chain. Overexpression of resistin in NRVM was also associated with activation of the mitogenactivated protein (MAP) kinases, ERK1/2 and p38, as well as increased Ser-636 phosphorylation of insulin receptor substrate-1 (IRS-1), indicating that IRS-1/MAPK pathway may be involved in the observed hypertrophic response. Overexpression of resistin in adult cultured cardiomyocytes significantly altered myocyte mechanics by depressing cell contractility as well as contraction and relaxation velocities. Intracellular Ca 2+ measurements showed slower Ca 2+ transients decay in resistin-transduced myocytes compared to controls, suggesting impaired cytoplasmic Ca 2+ clearing or alterations in myofilament activation. We conclude that resistin overexpression alters cardiac contractility, confers to primary cardiomyocytes all the features of the hypertrophic phenotype and promotes cardiac hypertrophy possibly via the IRS-1/MAPK pathway.

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Section: Discussionsupporting

confidence: 83%

Role of resistin in cardiac contractility and hypertrophy

Kim

Satoh

et al. 2008

Journal of Molecular and Cellular Cardiology

139

120

View full text Add to dashboard Cite

show abstract

“…Plasma resistin levels have been associated with markers of inflammation such as TNF-α, soluble TNF-α receptor-2, or IL-6 and moreover, resistin has been shown to be a predictive factor for coronary atherosclerosis in humans, independent of CRP [54,78,79]. It was recently shown that resistin correlates with the levels of biomarkers for cardiac injury, and it has been suggested as a marker of the severity of myocardium ischemic injury [80].…”

Section: Resistin and Atherosclerosismentioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

371

297

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“…Resistin in humans has also been linked to inflammatory processes and atherosclerosis. [15][16][17][18][19] Weight loss and caloric restriction have been shown to improve insulin resistance and lipid profiles. [20][21][22][23][24] The aim of the present study is to investigate the possible associations between resistin, body weight, glucose and lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

et al. 2006

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Objective: Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear. Design: Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects. Subjects: Healthy subjects, lean (n ¼ 20, BMIo25) and overweight (n ¼ 43, BMIX25). Measurements: Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention. Results: Serum resistin was positively correlated to HOMA-IR (partial r ¼ 0.288; P ¼ 0.055), serum fructosamines (partial r ¼ 0.280; P ¼ 0.062), serum NEFA (partial r ¼ 0.276; P ¼ 0.066) and negatively to age (partial r ¼ À0.349; P ¼ 0.019) and serum apolipoprotein A-1 (partial r ¼ À0.363; P ¼ 0.014). During the intervention, serum resistin increased significantly (Po0.001). The increase was inversely related to changes in waist-to-hip ratio (P ¼ 0.025) and positively to serum apolipoprotein B (P ¼ 0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r ¼ 0.703, P ¼ 0.007). No relation was observed between changes in resistin and changes in HOMA-IR. Conclusion: The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.

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The potential role of resistin in atherogenesis

Cited by 211 publications

References 23 publications

Role of resistin in cardiac contractility and hypertrophy

Role of resistin in cardiac contractility and hypertrophy

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

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