The Potential Role of Recombinant Hematopoietic Colony‐Stimulating Factors in Preventing Infections in the Immunocompromised Host

Abstract

. The potential role of recombinant hematopoietic colony-stimulating factors in preventing infections in the immunocompromised host . Can J Infect Dis 1991;2(2):74-88. Hematopoie ti c colony-stimu lating fac tors coordinate th e prolifera tion a nd maturation of bone marrow a nd periph era l blood cell s during norma l hematopoiesis . Most of these factors a re now avai lable as reco mbinant human colony-stimulating factors, a nd preclini cal a nd clin ical testing is proceeding ra pid ly. Granulocyte and granulocyte/ macrophage colony-stimulating factors ha ve been lhe mos l exten s ive ly stud ied to da le. In huma n cl inical trials. gran ulocyte colony-stimula ting fac tor improves n eutrophil counts and fun c tion . redu ces episod es of febrile n eutropenia, improves neutroph il recovery a fte r d isease-or treatment-induced myelosuppression. a nd reduces the number of serious infec tions in several ne utropenic disease stales. Granu locyte/macrophage co lony-s timula ting fac lor has s imila r biologica l properties but m ay also improve eosinophil prolifera tion a nd function. a nd pla telet ce ll recovery after myelotoxi c bon e m arrow injury. lnlerl eu!Gn -1 boosls th e effects of granu locyte colonys timulatin g fa cto r a n d granulocyte/ m acrophage colony-s timu lating faclor. but also m ay promote the resolu tion of established infec tion s in conjunc tion with a ntibiotics. The th era p eutic realiti es and fu ture thera peu tic implications of these agents for the th erapy of infectio n s, cancer and h emopoie tic disord ers a re d iscussed . Key Words: CoLony-stimuLa ting .factors. Feb rile neutropenia. H ematopoies is. NeutropeniaRole potentiel des facteurs recombinants stimulant les colonies hematopo"ietiques dans Ia prevention des infections chez l'hote immunodeprime RESUME: Les fac teu rs s timula nt les co lon ies h em atopoletiqu es coo rd onnent Ia prolifera tion et la m atura tion des ce llul es de Ia m oell e osseuse et du sang periph e riqu e a u cours de l' hematopolese nor mal e. La plupa rl de ces facleurs co nn us sou s le nom de "facteurs sti mul a nt les colonies" font acluell emen t l'obj e l d'evalua tion s precliniqu es e t cliniques qui progressenl

Evolution of efficacious pangenotypic hepatitis C virus therapies

“…BRMs are naturally present in the human body and can be synthesized in large amounts for treating cancer as well as autoimmune and infectious diseases . Typically, BRMs include monoclonal antibodies, IFNs, interleukins, and several types of colony‐stimulating factors . In 1991, IFN‐α gained FDA approval for treating HCV infections .…”

Biological response modifiers and infectious diseases: Actual and potential therapeutic agents

“…However, the advent of hybridoma, recombinant DNA, and gene insertion technologies have explosively widened the number of agents available for clinical testing. Agents which have been called BRMs now range from monoclonal antibodies [4], recombinant forms of interferons [5], interleukins [6], and colony-stimulating factors (CSFs) [7,8] to traditional Chinese medicines [9]. This review will focus primarily on agents whose mechanisms of action are at least partially understood and on those which are being or may soon be applied to the infectious diseases.…”