The potential role of P.gingivalis in gastrointestinal cancer: a mini review

Abstract

Bacterial infection may be involved in the entire process of tissue carcinogenesis by directly or indirectly affecting the occurrence and development of tumors. Porphyromonas gingivalis (P.gingivalis) is an important pathogen causing periodontitis. Periodontitis may promote the occurrence of various tumors. Gastrointestinal tumors are common malignant tumors with high morbidity, high mortality, and low early diagnosis rate. With the rapid development of molecularbiotechnology, the role of P.gingivalis in digestive tract tumors has been increasingly explored. This article reviews the correlation between P.gingivalis and gastrointestinal cancer and the pathogenesis of the latter. The relationship among P.gingivalis, periodontal disease, and digestive tract tumors must be clarifiedthrough a multi-center, prospective, large-scale study.

Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

“…More specifically, exposure to the bacterium Helicobacter Pylori is suggested as a risk factor for pancreatic cancer (14)(15)(16)(17). Data also suggest a positive association between periodontal disease, due to an infection of the periodontal bacterium Porphyromonas gingivalis and Fusobacterium species, and pancreatic cancer risk (8,(18)(19)(20)(21)(22)(23). The microbiota immune modulation promoting cancer pathogenesis has been explained through inflammatory processes in the tumor tissue, however it has also been shown in mice that bacteria not present in the tumorigenic tissue can promote carcinogenesis, nor do they need to cause inflammation in the tumor microenvironment (8,58).…”

“…Most studies focused on humoral responses to Helicobacter pylori and found contradicting results (14)(15)(16)(17). More recently, periodontal disease, caused by bacterial infections of pathogens such as Porphyromonas gingivalis and Fusobacterium species, has been suggested to play a role in the development and prognosis of pancreatic cancer (18)(19)(20)(21)(22)(23)(24). Furthermore, other responses of the humoral immune system, such as allergic reactions, may present a protective effect for pancreatic cancer diagnosis (25)(26)(27)(28)(29).…”

Periodontal disease in preoperative patients with digestive cancer: a retrospective, single-institution experience in Fukui, Japan

“…As a result, there have been many reports, mainly from Japanese researchers, regarding the effects of preoperative oral and dental health management for prevention of postoperative complications [ 2 , 4 – 6 ]. Furthermore, some recent literature has shown interesting information about the association between oral microbiota and malignant digestive diseases [ 7 , 8 ].…”

“…In recent years, there is growing evidence associating different mechanistic links between periodontitis and some malignant digestive diseases, as a noteworthy topic [ 8 , 10 ]. It is an important research field in order to provide oral health education to the general public.…”

Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells

“…Despite the epidemiological evidence implicating P. gingivalis in pancreatic tumorigenesis [ 19 ], the direct effects of this bacterium on PDAC tumor progression have not been investigated, and the mechanisms underlying the P. gingivalis –PDAC link remain unclear. Here, we provide the first evidence that P. gingivalis exerts direct pro-tumorigenic effects on pancreatic cancer cells.…”