The potential role of micro-RNA-211 in the pathogenesis of sleep-related hypermotor epilepsy

Župčić, Sandra Graf; Župčić, Miroslav; Đuzel, Viktor; Šimurina, Tatjana; Šakić, Livija; Grubješić, Igor; Tonković, Dinko; Udović, Ingrid Šutić; Ferreri, Vjera Matkovic

doi:10.1016/j.mehy.2020.110115

Cited by 2 publications

(1 citation statement)

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“…SHE occurs during the non-rapid eye movement (NREM) stage of sleep. The hypothesis proposed by Zupcic et al [ 32 ] is that seizures and the development of epileptogenesis in SHE are a consequence of cholinergic dysfunction and decreased levels of microRNA-211, as opposed to NREM parasomnias, where there is a stable level of microRNA-211, preventing epileptogenesis despite the cholinergic system dysfunction.…”

Section: Impact Of Micrornas On Sleep-related Epilepsymentioning

confidence: 99%

Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy

Dziadkowiak

Chojdak-Łukasiewicz

Olejniczak

et al. 2021

IJMS

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The effects of epilepsy on sleep and the activating effects of sleep on seizures are well documented in the literature. To date, many sleep-related and awake-associated epilepsy syndromes have been described. The relationship between sleep and epilepsy has led to the recognition of polysomnographic testing as an important diagnostic tool in the diagnosis of epilepsy. The authors analyzed the available medical database in search of other markers that assess correlations between epilepsy and sleep. Studies pointing to microRNAs, whose abnormal expression may be common to epilepsy and sleep disorders, are promising. In recent years, the role of microRNAs in the pathogenesis of epilepsy and sleep disorders has been increasingly emphasized. MicroRNAs are a family of single-stranded, non-coding, endogenous regulatory molecules formed from double-stranded precursors. They are typically composed of 21–23 nucleotides, and their main role involves post-transcriptional downregulation of expression of numerous genes. Learning more about the role of microRNAs in the pathogenesis of sleep disorder epilepsy may result in its use as a biomarker in these disorders and application in therapy.

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Section: Impact Of Micrornas On Sleep-related Epilepsymentioning

confidence: 99%