The potential role of leptin and adiponectin in obesity: A comparative review

Ricci, Rebecca; Bevilacqua, Francesca

doi:10.1016/j.tvjl.2011.04.009

Cited by 83 publications

(56 citation statements)

References 45 publications

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“…Different studies proved that serum level of adiponectin is reduced significantly with weight gain and obesity [115]. Studies in humans identified the role of visceral adipocytes in secreting adiponectin and other adipokines more than subcutaneous adipocytes, even though the decreased level of adiponectin in obesity is still unclear [106].…”

Section: Adiponectinmentioning

confidence: 99%

Obesity and inflammation: the linking mechanism and the complications

Ellulu

Patimah

Khaza’ai

et al. 2017

aoms

1,377

963

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Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. It is also associated with development of non-cardiovascular diseases such as psoriasis, depression, cancer, and renal diseases. On the other hand, a reduced level of adiponectin, a significant predictor of cardiovascular mortality, is associated with impaired fasting glucose, leading to type-2 diabetes development, metabolic abnormalities, coronary artery calcification, and stroke. Finally, managing obesity can help reduce the risks of cardiovascular diseases and poor outcome via inhibiting inflammatory mechanisms.

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Section: Adiponectinmentioning

confidence: 99%

Obesity and inflammation: the linking mechanism and the complications

Ellulu

Patimah

Khaza’ai

et al. 2017

aoms

1,377

963

View full text Add to dashboard Cite

show abstract

“…Although BCS is a subjective measurement made by a veterinarian's visual assessment of the animal, circulating leptin levels (as a marker of obesity in dogs) were elevated in dogs with a higher BCS (Ishioka et al, 2007;Ricci and Bevilacqua, 2012).…”

Section: Introductionmentioning

confidence: 99%

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim

Kim

et al. 2015

The Veterinary Journal

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“…One concern for the applicability of the ZDF rats to humans is the recessive homozygous mutation in the leptin receptor (fa) that causes loss of function and induces severe hyperphagia (Davis, Cain, Banz, & Peterson, 2013; Reinwald, Peterson, Allen, & Burr, 2009). Leptin has been shown to have an array of effects that may influence development of the metabolic syndrome (Beltowski, 2012; Gade, Schmit, Collins, & Gade, 2010; Kaur, 2014; Ricci & Bevilacqua, 2012). Thus, loss of leptin signaling in the ZDF rat makes it a less than ideal model for complications of type 2 diabetes in humans, who generally do not have a leptin-receptor deficit.…”

Section: Rodent Models Of Type 2 Diabetesmentioning

confidence: 99%

Alternatives to the Streptozotocin-Diabetic Rodent

Yorek

2016

International Review of Neurobiology

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The study of diabetic neuropathy has relied primarily on the use of streptozotocin-treated rat and mouse models of type 1 diabetes. This chapter will review the creation and use of other rodent models that have been developed in order to investigate the contribution of factors besides insulin deficiency to the development and progression of diabetic neuropathy as it occurs in obesity, type 1 or type 2 diabetes. Diabetic peripheral neuropathy is a complex disorder with multiple mechanisms contributing to its development and progression. Even though many animal models have been developed and investigated, no single model can mimic diabetic peripheral neuropathy as it occurs in humans. Nonetheless, animal models can play an important role in improving our understanding of the etiology of diabetic peripheral neuropathy and in performing preclinical screening of potential new treatments. To date treatments found to be effective for diabetic peripheral neuropathy in rodent models have failed in clinical trials. However, with the identification of new endpoints for the early detection of diabetic peripheral neuropathy and the understanding that a successful treatment may require a combination therapeutic approach there is hope that an effective treatment will be found.

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The potential role of leptin and adiponectin in obesity: A comparative review

Cited by 83 publications

References 45 publications

Obesity and inflammation: the linking mechanism and the complications

Obesity and inflammation: the linking mechanism and the complications

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Alternatives to the Streptozotocin-Diabetic Rodent

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