The potential role of 2D-speckle tracking echocardiography for detecting left ventricular systolic dysfunction in patients with Parkinson’s disease: a case control study

Mokadem, Mostafa El; Hassan, Amr; Hussein, Mona; Mohamed, Yousef Mohsen

doi:10.1080/00015385.2020.1858251

Cited by 3 publications

(7 citation statements)

References 28 publications

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“…Our results indicate that GLS may be a more sensitive index to predict left ventricular systolic dysfunction in PD patients as compared to LVEF, the index commonly used to measure left ventricular systolic function 28 . Other studies have also demonstrated that GLS parameters provide more sensitive measurements of cardiac function since contractile performance is directly quantified 29,30 . The sensitivity of GLS may indicate left ventricular systolic dysfunction at an early stage, which is important for PD patients since they have a higher risk of death due to heart failure 12 …”

Section: Discussionmentioning

confidence: 69%

“…12 El Mokadem et al also reported a correlation between the H-Y score and both global longitudinal systolic and ejection fraction parameters. 30 Moreover, they also reported a correlation between increased disease duration and poor GLS values. As in our study, they did not find differences in left ventricular end systolic or diastolic…”

Section: Discussionmentioning

confidence: 96%

“…28 Other studies have also demonstrated that GLS parameters provide more sensitive measurements of cardiac function since contractile performance is directly quantified. 29,30 The sensitivity of GLS may indicate left ventricular systolic dysfunction at an early stage, which is important for PD patients since they have a higher risk of death due to heart failure. 12 El Mokadem et al also reported a correlation between the H-Y score and both global longitudinal systolic and ejection fraction parameters.…”

Section: Discussionmentioning

confidence: 99%

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Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

Shi,

Du,

et al. 2023

J of Clinical Ultrasound

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AimThis study aimed to evaluate cardiac function, particularly left ventricular systolic function, in patients with Parkinson disease (PD) using velocity vector imaging (VVI), and to determine whether a correlation exists between left ventricular global systolic function and PD severity.MethodsA case–control study design was used to select 56 PD patients and 30 healthy controls from January 2019 to December 2019. The characteristics of age, sex, BMI and course of disease were collected. The Hoehn–Yahr (H‐Y) score was collected to record the grading of PD. The left ventricular systolic function of all patients was evaluated by variable vapor injection (VVI). The left ventricular systolic function was compared between the case group and the control group, and the correlation between cardiac dysfunction and the severity of PD symptoms was assessed using the modified H‐Y scale.ResultsCompared with control group, left ventricular global systolic function18.22 (17.08, 19.12) vs 18.88 (18.12, 20.01) was lower in PD patients as indicated by left ventricular global longitudinal strain (GLS), and the difference was statistically significant (P = 0.039). Additionally, H‐Y scores (r = −0.404) and PD duration(r = −0.323) were significantly correlated with reduced left ventricular ejection fraction (P < 0.01), GLS (P < 0.001), left ventricular global radial strain (GRS; P < 0.001), and left ventricular global circumferential strain (GCS; P < 0.001), along with their associated peak strain rates (GLSr, GRSr, and GCSr; P < 0.001).ConclusionSubclinical left ventricular global systolic dysfunction in patients with PD can be detected using VVI, and reduced left ventricular systolic function correlates with the modified H‐Y score and duration of the disease.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

Shi,

Du,

et al. 2023

J of Clinical Ultrasound

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“…While sleep is better understood now in PD, there is still a need to understand how cardiac function is affected in PD. Indeed, using echocardiography, PD patients have shown reduced global longitudinal strain and ejection fraction, along with elevated left ventricular end-diastolic and systolic dimensions [4]. The authors state there does appear to be subclinical left ventricular systolic dysfunction in PD patients, which does correlate with cognitive impairment [4].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, using echocardiography, PD patients have shown reduced global longitudinal strain and ejection fraction, along with elevated left ventricular end-diastolic and systolic dimensions [4]. The authors state there does appear to be subclinical left ventricular systolic dysfunction in PD patients, which does correlate with cognitive impairment [4]. Heart rate variability (HRV) is a commonly used technique for the assessment of autonomic function, with depressed HRV in patients with PD [5].…”

Section: Introductionmentioning

confidence: 99%

Parkinson’s Disease and the Cardiac Cycle: A Rapid Literature Review and Case Series

Bardutz

Singh

Rehman

et al. 2023

Life

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Background and Objectives: Cardiac function in patients with Parkinson’s Disease (PD) is not well understood. We conducted a review of the literature to summarize all available data on the cardiac cycle in patients with PD and followed up the review with a case series to describe the cardiac cycle timing intervals in this patient population. Methods: Using the search terms (“Cardiac cycle” OR “echocardiography” OR “LVET” OR “IVCT” OR “IVRT” OR “LVEF” OR “Systolic Dysfunction” OR “Diastolic Dysfunction”) AND (“Parkinson’s Disease”), 514 studies were found with 19 included in the review. Results: Studies focused on the impact of medication, the presence of autonomic dysfunction, and resting-state, descriptive observational studies which considered the cardiac cycle. While inconsistent, the evidence suggests that patients with PD have some systolic dysfunction, with recent research implying the presence of subclinical systolic dysfunction. From the case series, 13 participants with PD were included and collected cardiac data daily for 6 weeks. Heart rate was consistent on a weekly basis at 67–71 bpm. Mean week-by-week cardiac parameters were also consistent with the systolic time interval at 332–348 ms, isovolumic relaxation time at 92–96 ms, and isovolumic contraction time at 34–36 ms. Conclusion: These timing intervals add valuable normative values for this patient population and the review of the literature suggests that more research is required to better understand cardiac cycle timing intervals in patients with Parkinson’s Disease.

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The State of Play of Parkinson’s Disease in Africa: A Systematic Review and Point of View

Okunoye

Zewde

Azar

et al. 2023

Preprint

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Background: Parkinson's disease (PD) has become a global public health challenge as disability and death due to the disease are growing rapidly in comparison to other neurological disorders. There are no up-to-date comprehensive reviews on the epidemiology, environmental and genetic risk factors, phenotypic characterization, and patient-reported outcomes of PD in Africa. This data is crucial to understanding the current and future burden and suggesting actionable and/or researchable gaps aimed at improving disease outcomes. Methodology: We conducted a systematic literature search using the electronic databases of Cochrane Central Register of Controlled Trials (CCRT), EMBASE, Medline, PsychINFO, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), African Journals (AJOL) and other unpublished literature. We included all studies providing data on people with PD in Africa from the start of each database till February 2023. Studies were not restricted based on diagnostic criteria or language. Outcomes of interest were summarised based on epidemiology, genetics, environmental risk factors, clinical characteristics, patient-reported outcomes (experience and quality of life), disease management and outcomes, access to care, patient support, and healthcare workforce training. We also investigated collaboration between African countries (internal) and across continents/world regions (external) and journal impact factors. Results: A total of 4,855 articles were identified, of which 180 were included in this review. The majority were published from North Africa (mainly from Tunisia, and involved collaboration with investigators from France, the United Kingdom, and the United States of America). West Africa (Nigeria), Southern Africa (South Africa) and East Africa (mainly Tanzania) also had a relatively high number of publications. Methodological design varied across studies. Based on the pre-determined outcomes, articles identified were genetics (67), clinical features (65), environmental risk factors (16), epidemiology (14), patient experience and quality of life (10), management and access to care (5) and education and training (3). Conclusions: The main hubs of PD-related research output in Africa are the Northern, Western and Southern regions of Africa (although with limited involvement of countries within these regions). External collaboration (outside the continent) currently predominates. There are considerable actionable and researchable gaps across all outcomes of interest, with a dearth of published information on health workforce capacity building, disease management and access to care, patient and caregiver engagement, and quality of life of people with PD in Africa. We recommend strengthening existing and emerging intercontinental networks for research, education, training and policy formulation and funding, leveraging on more recent developments such as the International Parkinson's Disease Genomics Consortium-Africa (IPDGC-Africa), the International Parkinson and Movement Disorder Society Africa Section (MDS-AS), World Health Organisation (WHO) and initiatives with similar objectives.

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The potential role of 2D-speckle tracking echocardiography for detecting left ventricular systolic dysfunction in patients with Parkinson’s disease: a case control study

Cited by 3 publications

References 28 publications

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease

Parkinson’s Disease and the Cardiac Cycle: A Rapid Literature Review and Case Series

The State of Play of Parkinson’s Disease in Africa: A Systematic Review and Point of View

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