The Potential Relationship Between Different Human Female Reproductive Disorders and Sperm Quality in Female Genital Tract

Mahdavinezhad, Forough; Gharaei, Roghaye; Farmani, Ahmad Reza; Hashemi, Farideh; Kouhestani, Mahsa; Amidi, Fardin

doi:10.1007/s43032-021-00520-7

Cited by 8 publications

(8 citation statements)

References 191 publications

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“…Транспортировка сперматозоидов через женский репродуктивный тракт имеет важное значение для достижения оплодотворения. Результаты исследований продемонстрировали, что ВМС могут нарушать цервико-маточно-тубарный транспорт сперматозоидов [17][18][19][20][21]. Вместе с тем шейка матки синтезирует высокогидратированную слизь, и сперматозоиды продвигаются по цервикальному каналу благодаря особенностям шеечной слизи [18,19].…”

Section: влияние внутриматочных спаек на репродуктивную функциюunclassified

Intrauterine adhesions: from pathogenesis to effective coping technologies

et al. 2023

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Intrauterine adhesions (IUDs) are one of the unresolved and unsolved problems of modern reproductive medicine worldwide. Adhesive lesions lead to partial or complete obliteration of the uterine cavity and/or cervical canal. The main clinical manifestations of IUDs are menstrual irregularities, cyclical pain, infertility and other various reproductive disorders. Reproductive outcomes in women with IUDs remain poorly understood and difficult to verify. At the same time, there is currently no understanding of the basic mechanisms of IUD development, including the processes explaining the failures of the above complications. The problem of overcoming IUD recurrences after adhesiolysis remains far from being finally resolved. The gold-standard treatment for IUD is hysteroscopic adhesiolysis, which, however, is associated with a high frequency of complications and relapses, highlighting the need for preventive approaches to the management of IUD. The drugs with enzymatic activity inhibiting abnormal connective tissue include bovhyaluronidase azoximer created by the Russian developers back in 2005. The drug consists of two components – hyaluronidase and azoximer bromide. The former is an enzyme, and the latter is a stabilizer that prolongs the action of hyaluronidase. Several studies have shown that bovhyaluronidase azoximer causes the destruction of intrauterine adhesions and restores the endometrium status in inflammatory pelvic diseases. Due to prolonged antifibrotic effect of bovhyaluronidase, azoximer can be used to treat women with IUDs to reduce the risk of the subsequent development of adhesive process in the uterine cavity.

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Section: влияние внутриматочных спаек на репродуктивную функциюunclassified

Intrauterine adhesions: from pathogenesis to effective coping technologies

et al. 2023

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“…reported the elevated levels of IL‐1β in the varicocele patients compared to the normal group 71 . The presence of inflammatory cytokines and leukocytes in semen can have detrimental effects on spermatozoa by the production of INF‐γ, leading to apoptosis and decreased sperm motility 72–74 . In addition, it has been suggested that TNF‐α induces sperm chromatin and DNA damage, elevated level of phosphatidylserine externalization, reduced sperm motility, and mitochondrial membrane potential of human spermatozoa in a concentration‐ and time‐dependent manner 75 …”

Section: Overlap Between Common Symptoms Of Varicocele and Known Risk...mentioning

confidence: 99%

“…71 The presence of inflammatory cytokines and leukocytes in semen can have detrimental effects on spermatozoa by the production of INF-γ, leading to apoptosis and decreased sperm motility. [72][73][74] In addition, it has been suggested that TNF-α induces sperm chromatin and DNA damage, elevated level of phosphatidylserine externalization, reduced sperm motility, and mitochondrial membrane potential of human spermatozoa in a concentration-and time-dependent manner. 75 The research findings have demonstrated that COVID-19 is evidenced by excessive host immune response, resulting in the increased levels of inflammatory responses or cytokine storm.…”

Section: Inflammatory Cytokinesmentioning

confidence: 99%

COVID‐19 and varicocele: The possible overlap factors and the common therapeutic approaches

Mahdavinezhad

Farmani

Pakniat

et al. 2022

American J Rep Immunol

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Varicocele is recognized as one of the main attributable causes of male infertility which can affect spermatogenesis by various pathophysiological mechanisms. Recent studies have identified oxidative stress and reduction in antioxidant, hyperthermia, hypoxia, hormonal dysfunction, and inflammatory conditions as major factors in the pathophysiology of varicocele, all of which have known direct associations with the coronavirus disease 2019 (COVID-19) and can significantly increase the risk of detrimental COVID-19-related outcomes. Emerging data have shown an association between COVID-19 and inflammation, overproduction of cytokine, and other pathophysiological processes. The present review, summarizes the current understanding of the pathophysiology of varicocele and investigates the potential correlation between the severity of COVID-19 and the varicocele disease. In addition, various possible treatments which can be effective in both diseases were examined. Despite numerous challenges associated with the prevalence of COVID-19 in healthcare systems in infected countries, special attention should be given to maintaining a high level of care for complex patients with a pre-existing disease such as varicocele and providing appropriate practical advice for optimal control of the COVID-19 disease.

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“…Stem cells can self-renew, proliferate, and differentiate into target tissue cells in the presence of relevant growth factors when in biomaterials with supportive architecture, composition, and mechanics [ 15 , 16 ]. However, some studies have shown that stem cells are the cause of pathological conditions and have a role in cancer [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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The Potential Relationship Between Different Human Female Reproductive Disorders and Sperm Quality in Female Genital Tract

Cited by 8 publications

References 191 publications

Intrauterine adhesions: from pathogenesis to effective coping technologies

Intrauterine adhesions: from pathogenesis to effective coping technologies

COVID‐19 and varicocele: The possible overlap factors and the common therapeutic approaches

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

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