The potential rationale of COVID‐19 vaccine‐induced myopericarditis

Myopericarditis in young subjects after vaccination, clearing the clouds of misunderstanding

“…To the Editor, The recent letter by colleagues from the Poznan University of Medical Sciences (Poland), reports a rationale that reviews the dosage of the coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine to prevent vaccine-induced myopericarditis in young subjects. 1 The authors suggest moreover that one possible causative factor leading to myocardial injury from COVID-19 mRNA vaccines in young adults may be related to a stronger immune response in the youth with respect to older individuals. 1 Au and Assavarittirong refer to a scientific contribution by A recent paper by Krug et al, 6 for example, studying 253 cases of myopericarditis, reported that in 129 cases after the first dose and 124 cases after the second dose of vaccine, a percentage of 86.9% of them were hospitalized, evidence allowing the authors to assess that the incidence per million, following the second dose of vaccine, was 162.2 (ages: 12-15) and 93.0 (ages: 16-17).…”

“…1 The authors suggest moreover that one possible causative factor leading to myocardial injury from COVID-19 mRNA vaccines in young adults may be related to a stronger immune response in the youth with respect to older individuals. 1 Au and Assavarittirong refer to a scientific contribution by A recent paper by Krug et al, 6 for example, studying 253 cases of myopericarditis, reported that in 129 cases after the first dose and 124 cases after the second dose of vaccine, a percentage of 86.9% of them were hospitalized, evidence allowing the authors to assess that the incidence per million, following the second dose of vaccine, was 162.2 (ages: 12-15) and 93.0 (ages: 16-17). If confirmed, and a huge bulk of evidence seems to support this perspective, vaccination should be quite exclusively recommended to at-risk populations, such as elderly individuals, rather than youngest subjects, who very rarely undergo hospitalization for severe COVID-19.…”