The potential of unsaturated polyesters in biomedicine and tissue engineering: Synthesis, structure-properties relationships and additive manufacturing

Gonçalves, F.A.M.M.; Fonseca, A. C.; Domingos, Marco; Gloria, Antonio; Serra, Arménio C.; Coelho, Jorge F. J.

doi:10.1016/j.progpolymsci.2016.12.008

Cited by 74 publications

(36 citation statements)

References 158 publications

(214 reference statements)

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“…For instance, polythioesters with a functional tertiary amine display facile functionalization and allow further biomolecule coupling [ 110 ]. Polyesters are flexible biodegradable and resorbable polymers, and come in hand for valves and tissue regeneration applications [ 111 , 112 , 113 , 114 ]. Instead, if the need of a bioinert, stronger and tougher polymer is required, polyurethanes (PUs) are the polymers of choice.…”

Section: Synthetic Criteria For Hydrogel Productionmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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Section: Synthetic Criteria For Hydrogel Productionmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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“…Thermosets produced from bio‐based UPEs offer wide potential uses in applications such fibreglass composites, sheet moulding compounds and bulk moulding compounds. Cytotoxicities of thermosets are typically lower than for thermoplastics, and as a result they are often suitable for biomedical applications . One such example from Sakuma et al .…”

Section: Post‐polymerization Modification Via Ccmentioning

confidence: 99%

Post‐polymerization modification of bio‐based polymers: maximizing the high functionality of polymers derived from biomass

Farmer

Comerford

Pellis

et al. 2018

Polymer International

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The renaissance of the bio-based chemical industry over the last 20 years has seen an ever growing interest in the synthesis of new bio-based polymers. The building blocks of these new polymers, so called platform molecules, contain significantly more chemical functionality than their petrochemical counterparts (such as ethene, propene and para-xylene). As a result bio-based polymers often contain greater residual chemical functionality in their chains, with groups such as alkenes and hydroxyls commonly observed. These functional groups can act as sites for post-polymerization modification (PPM), thus further extending the range of applications for bio-based polymers by tailoring the polymers' final properties. This mini-review highlights some of the most recent and compelling examples of how to make use of bio-based polymers with residual functional groups for PPM. It also looks at how the emerging interdisciplinary field of enzymatic polymer synthesis allows for increased functionality in polymers by avoiding side-reactions as a result of milder reaction conditions, and additionally offers an alternative means of polymer surface modification.

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“…Unsaturated polyesters (UPEs) are among the most versatile synthetic resins used in the manufacture of composite polymers [1,2]. Unsaturated polyester resins (UPRs) have a wide range of applications, for example, in the construction sector, as well as in the field of transportation, tissue engineering and electronics [3][4][5]. Important applications of UPEs can be found in automotive, electric and electronic sectors as well as in military products, furniture, sport, leisure, domestic and sanitary appliances [6,7].…”

Section: Introductionmentioning

confidence: 99%

Environmental Profile and Technological Validation of New High-Tg Unsaturated Polyesters from Fully Bio-Based Monomers and Reactive Diluents

2020

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This study was focused on the synthesis and characterization of a fully bio-based unsaturated polyester resin (UPR) with good thermal properties suitable for the commercial production of composite polymers. UPRs based on different ratios of bio-based furan dicarboxylic acid (FDCA), itaconic acid, and diols were synthesized. The unsaturated polymers prepared were evaluated by differential scanning calorimetry, gel permeation chromatography, FTIR and 1H-NMR spectroscopy. The results showed positive effects of FDCA on the glass transition temperature (Tg) of these fully bio-based polyesters, especially when FDCA was combined with 1,2-propanediol. Optimal values of Tg were obtained in the range of 30–32 °C for UPRs synthesized starting with a higher concentration of FDCA in the monomer feed. The possibility of substituting styrene, which usually acts as a reactive diluent, with a greener and safer alternative during the crosslinking of UPRs, was also explored. Two bio-based reactive diluents were considered: dimethyl itaconate (DMI) and butanediol dimethacrylate. After crosslinking, an average Tg of 75 °C and a good crosslinking efficiency indicated by a gel content of 90% were achieved for the fully bio-based polyester obtained under milder reaction conditions and dilution with DMI. Life cycle assessment was performed on selected UPRs, and comparison with a reference fossil-based resin in terms of the calculated category indicator results confirmed the lower environmental impact of the newly prepared bio-based polyesters.

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The potential of unsaturated polyesters in biomedicine and tissue engineering: Synthesis, structure-properties relationships and additive manufacturing

Cited by 74 publications

References 158 publications

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Post‐polymerization modification of bio‐based polymers: maximizing the high functionality of polymers derived from biomass

Environmental Profile and Technological Validation of New High-Tg Unsaturated Polyesters from Fully Bio-Based Monomers and Reactive Diluents

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