The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area

Sun, Jie; Hynynen, Kullervo

doi:10.1121/1.426863

Cited by 129 publications

(92 citation statements)

References 27 publications

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“…Thus, it is preferable to use CT-derived skull information to compensate for the distortion induced by the skull on TAT brain images in real applications. 11,20 With good image registration, the skull information obtained with CT can be used with TAT for longterm monitoring of brain disorder.…”

Section: Discussionmentioning

confidence: 99%

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

Jin

Wang

2008

Med. Phys.

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The effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography were studied. A numerical model for calculating the propagation of thermoacoustic waves through the skull was developed and experimentally examined. The model takes into account wave reflection and refraction at the skull surfaces and therefore provides improved accuracy for the reconstruction. To evaluate when the skull-induced effects could be ignored in reconstruction, the reconstructed images obtained by the proposed method were further compared with those obtained with the method based on homogeneous acoustic properties. From simulation and experimental results, it was found that when the target region is close to the center of the brain, the effects caused by the skull layer are minimal and both reconstruction methods work well. As the target region becomes closer to the interface between the skull and brain tissue, however, the skull-induced distortion becomes increasingly severe, and the reconstructed image would be strongly distorted without correcting those effects. In this case, the proposed numerical method can improve image quality by taking into consideration the wave refraction and mode conversion at the skull surfaces. This work is important for obtaining good brain images when the thickness of the skull cannot be ignored.

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Section: Discussionmentioning

confidence: 99%

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

Jin

Wang

2008

Med. Phys.

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“…More recently, several technologies and methodologies were studied and developed for improving the efficiency of ultrasound transmission through the skull bone; these have included the development of high-power large aperture transducers (Sun & Hynynen 1999), and the capability for controlled modulation of acoustic power and phase from multiple ultrasound sources (Daum et al 1998). The focused, large-aperture geometry of transcranial energy transmission minimized localized skull heating while the segmentation of transducers into individually controllable ultrasound sources provided a method to adaptively correct for phase and amplitude distortions.…”

Section: Introductionmentioning

confidence: 99%

Local frequency dependence in transcranial ultrasound transmission

2006

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The development of large-aperture multiple-source transducer arrays for ultrasound transmission through the human skull has demonstrated the possibility of controlled and substantial acoustic energy delivery into the brain parenchyma without the necessitation of a craniotomy. The individual control of acoustic parameters from each ultrasound source allows for the correction of distortions arising from transmission through the skull bone and also opens up the possibility for electronic steering of the acoustic focus within the brain. In addition, the capability to adjust the frequency of insonation at different locations on the skull can have an effect on ultrasound transmission. To determine the efficacy and applicability of a multiple-frequency approach with such a device, this study examined the frequency dependence of ultrasound transmission in the range of 0.6-1.4 MHz through a series of seventeen points on four ex vivo human skulls. Effects beyond those that are characteristic of frequency-dependent attenuation were examined. Using broadband pulses, it was shown that the reflected spectra from the skull revealed information regarding ultrasound transmission at specific frequencies. A multiple-frequency insonation with optimized frequencies over the entirety of five skull specimens was found to yield on average a temporally brief 230% increase in the transmitted intensity with an 88% decrease in time-averaged intensity transmission within the focal volume. This finding demonstrates a potential applicability of a multiple-frequency approach in transcranial ultrasound transmission.

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“…Recent advances in ultrasound transducer technology 3,6,7,27,28,36,37,51,52,60 have enabled transcranial sonication to be precisely focused to deep targets in the brain with MR guidance and temperature monitoring, 8,15,30,40,42 avoiding the superficial burns that were noted in earlier studies. 35 In fact, the first human trials for treatment of glioma and neuropathic pain have proven that FUS can be delivered through the intact human skull to heat targets 39 and even ablate them 38 with precision.…”

mentioning

confidence: 99%

A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus

Elias¹,

Khaled²,

Hilliard³

et al. 2013

JNS

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Object The purpose of this study was to use MRI and histology to compare stereotactic lesioning modalities in a large brain model of thalamotomy. Methods A unilateral thalamotomy was performed in piglets utilizing one of 3 stereotactic lesioning modalities: focused ultrasound (FUS), radiofrequency, and radiosurgery. Standard clinical lesioning parameters were used for each treatment; and clinical, MRI, and histological assessments were made at early (< 72 hours), subacute (1 week), and later (1–3 months) time intervals. Results Histological and MRI assessment showed similar development for FUS and radiofrequency lesions. T2-weighted MRI revealed 3 concentric lesional zones at 48 hours with resolution of perilesional edema by 1 week. Acute ischemic infarction with macrophage infiltration was most prominent at 72 hours, with subsequent resolution of the inflammatory reaction and coalescence of the necrotic zone. There was no apparent difference in ischemic penumbra or “sharpness” between FUS or radiofrequency lesions. The radiosurgery lesions presented differently, with latent effects, less circumscribed lesions at 3 months, and apparent histological changes seen in white matter beyond the thalamic target. Additionally, thermal and radiation lesioning gradients were compared with modeling by dose to examine the theoretical penumbra. Conclusions In swine thalamus, FUS and radiosurgery lesions evolve similarly as determined by MRI, histological examination, and theoretical modeling. Radiosurgery produces lesions with more delayed effects and seemed to result in changes in the white matter beyond the thalamic target.

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The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area

Cited by 129 publications

References 27 publications

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

Local frequency dependence in transcranial ultrasound transmission

A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus

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