The potential of the use of deep eutectic solvents and amino acid-based ionic liquids to enhance the chiral discrimination ability of different chiral selectors in capillary electrophoresis

Ioannou, Katerina A.; Ioannou, Georgia D.; Christou, Atalanti; Stavrou, Ioannis J.; Schmid, Martin G.; Kapnissi‐Christodoulou, Constantina P.

doi:10.1016/j.chroma.2023.464152

Cited by 9 publications

(2 citation statements)

References 62 publications

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“…They are composed of hydrogen bond donors and hydrogen bond acceptors with a certain stoichiometric ratio. The majority of literature pertaining to DESs was designed for extraction, catalysis, or electrochemistry purposes, whereas the study of DESs in the field of CE is still in its infancy. − Li et al conducted a comparative study on how DESs affect CE chiral separations . The results show that most of the selected DESs could moderately improve the enantioresolutions of model drugs, and this improvement was mainly attributed to the contribution of the hydrogen bond acceptors rather than the hydrogen bond donors.…”

Section: Methods Development and Technology Advancesmentioning

confidence: 99%

Capillary Electrophoresis: A Three-Year Literature Review

Li,

Miao,

Tan

et al. 2024

Anal. Chem.

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Section: Methods Development and Technology Advancesmentioning

confidence: 99%

Capillary Electrophoresis: A Three-Year Literature Review

Li,

Miao,

Tan

et al. 2024

Anal. Chem.

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“…Ionic liquids (ILs) are a kind of molten salts consisting entirely of anions and cations [9]. Thus far, ILs have been widely used for enantioseparation in CE both as buffer additives [10,11] and as chiral selectors [12][13][14]. Undeniably, the addition of ILs, particularly chiral ionic liquids into buffers, can significantly improve the separations.…”

Section: Introductionmentioning

confidence: 99%

Investigation on improvement of enantioseparation based on clindamycin phosphate by chiral deep eutectic solvents in capillary electrophoresis

Ma,

Fan,

Tang

et al. 2024

J of Separation Science

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In this work, the potential synergetic effect between deep eutectic solvents and an antibiotic chiral selector (clindamycin phosphate) for enantioseparation was investigated in capillary electrophoresis. We synthesized a series of deep eutectic solvents with choline chloride as hydrogen bond acceptor and three α‐hydroxyl acids (l‐lactic acid, l‐malic acid, and l‐tartaric acid) as hydrogen bond donors. Compared to the single clindamycin phosphate separation system, significantly improved separations of model drugs were observed in several synergetic systems. Compared to deep eutectic solvents with a single hydrogen bond donor, deep eutectic solvents with mixed‐type hydrogen bond donors were superior. The influences of several key parameters including the type and proportion of organic modifier, clindamycin phosphate concentrations, deep eutectic solvents concentrations, and buffer pH were investigated in detail. The mechanism of the enhanced separations in deep eutectic solvents systems was investigated by means of electroosmotic flow analysis, nuclear magnetic resonance analysis, and molecular modeling. It was the first time that the synergetic systems between deep eutectic solvents and antibiotic chiral selector were established in capillary electrophoresis, and these deep eutectic solvents were demonstrated to have a good synergetic effect with clindamycin phosphate for enantioseparation.

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