The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults

Likoswe, Blessings H.; Lark, R. Murray; Phuka, John; Maleta, Kenneth; Joy, Edward J.M.; Lowe, Nicola M

doi:10.3389/fnut.2022.890209

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, other biomarkers have been evaluated that could be valuable elements to assess zinc status in the future, such as, for example, urinary zinc excretion, zinc concentration in hair, or zinc-binding proteins, such as metallothionein (MT). The results in the literature regarding these biomarkers are still controversial [ 14 , 15 , 16 , 17 , 18 ]. In addition, a presumptive diagnosis of ZnD can be made based on the presence of symptoms of zinc deficiency, signs of malnutrition, or conditions commonly associated with ZnD [ 6 , 13 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View

Padoan,

Piccoli,

Pietrobelli

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Zinc is an important trace element for growth and health at pediatric ages. Zinc is fundamental in inflammatory pathways, oxidative balance, and immune function. Zinc exhibits anti-inflammatory properties by modulating Nuclear Factor-kappa (NF-κB) activity and reducing histamine release from basophils, leukocytes, and mast cells. Furthermore, its antioxidant activity protects against oxidative damage and chronic diseases. Finally, zinc improves the ability to trigger effective immune responses against pathogens by contributing to the maturation of lymphocytes, the production of cytokines, and the regulation of apoptosis. Given these properties, zinc can be considered an adjunctive therapy in treating and preventing respiratory, nephrological, and gastrointestinal diseases, both acute and chronic. This review aims to deepen the role and metabolism of zinc, focusing on the role of supplementation in developed countries in pediatric diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View

Padoan,

Piccoli,

Pietrobelli

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

Single hair analysis by X-ray fluorescence spectrometry detects small changes in dietary zinc intake: A nested randomized controlled trial

et al. 2023

Self Cite

View full text Add to dashboard Cite

The aim of this study was to determine whether X-ray fluorescence spectrometry (XRF) could be used to detect changes in hair zinc concentration in response to a modest daily increase in zinc from the consumption of zinc biofortified wheat flour. This study was conducted as part of an effectiveness trial (BiZiFED2) exploring the potential for zinc biofortified wheat to alleviate zinc deficiency in adolescent girls aged 10–16 years in Pakistan (trial registration ID ISRCTN17107812). A randomized controlled design was used. Participants received either control flour or zinc biofortified flour for 6 months. Consumption of biofortified flour resulted in an average daily increase in dietary zinc intake of 1.5 mg per day above that of the control flour. At baseline and at the end of the intervention, individual hair samples (control: n = 59, intervention: n = 64) were analyzed for zinc and sulfur content by XRF. Data were analyzed using linear mixed effects models to contrast between trial groups the changes from baseline to end point and also to compare baseline and end point values within each trial group. Increases from baseline to endpoint in both sulfur and zinc were significantly greater in the intervention group compared to control (sulfur counts. Control: baseline = 119.87 ± 20.33 and endpoint = 121.58 ± 23.58/intervention: baseline = 122.67 ± 24.19 and endpoint = 131.60 ± 21.34); (Zinc counts. Control: baseline = 50.88 ± 14.33 and endpoint = 54.82 ± 14.61/intervention: baseline = 49.61 ± 10.77 and endpoint = 58.79 ± 12.20). For these parameters, there were also significant increases from baseline to endpoint in the intervention group but not in control. Furthermore, for Zn:S count ratio there were no differences in terms of the magnitude of the change from baseline to endpoint in the control group, although significant increases from baseline to endpoint were evident in the intervention group (Zn:S count ratio. Control: baseline = 0.42 ± 0.10 and endpoint = 0.45 ± 0.08/intervention: baseline = 0.41 ± 0.08 and endpoint = 0.45 ± 0.08). A modest increase in dietary zinc over 6 months resulted in a detectable increase in both sulfur and zinc counts in individual hairs measured using XRF. This offers a sensitive, non-invasive method to monitor changes within subjects in response to dietary zinc interventions.

show abstract

The potential of spot urine as a biomarker for zinc assessment in Malawian children and adults

Cited by 2 publications

References 35 publications

The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View

The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View

Single hair analysis by X-ray fluorescence spectrometry detects small changes in dietary zinc intake: A nested randomized controlled trial

Contact Info

Product

Resources

About