The potential of sheep for the study of osteopenia: Current status and comparison with other animal models

Newman, Eric D.; Turner, A. Simon; Wark, John D.

doi:10.1016/s8756-3282(95)80121-9

Cited by 210 publications

(124 citation statements)

References 35 publications

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“…There are many animal models for dental implant research, each having differences in bone remodelling and bony architecture, with potential advantages and disadvantages [22]. Sheep have been used as an animal model for various fields of biomedical research [23–26]. A mandibular oral implant model using domestic sheep has been investigated [24].…”

Section: Introductionmentioning

confidence: 99%

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Siddiqi

Duncan

Silva

et al. 2016

BioMed Research International

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Reports have documented titanium (Ti) hypersensitivity after dental implant treatment. Alternative materials have been suggested including zirconia (Zr) ceramics, which have shown predictable osseointegration in animal studies and appear free of immune responses. The aim of the research was to investigate the bone-to-implant contact (BIC) of one-piece Zr, compared with one-piece Ti implants, placed in the jaws and femurs of domestic sheep. Ten New Zealand mixed breed sheep were used. A One-piece prototype Ti (control) and one Zr (test) implant were placed in the mandible, and one of each implant (Ti and Zr) was placed into the femoral epicondyle of each animal. The femur implants were submerged and unloaded; the mandibular implants were placed using a one-stage transgingival protocol and were nonsubmerged. After a healing period of 12 weeks, %BIC was measured. The overall survival rate for mandibular and femur implants combined was 87.5%. %BIC was higher for Zr implants versus Ti implants in the femur (85.5%, versus 78.9%) (p = 0.002). Zirconia implants in the mandible showed comparable %BIC to titanium implants (72.2%, versus 60.3%) (p = 0.087). High failure rate of both Zr and Ti one-piece implants in the jaw could be attributed to the one-piece design and surface characteristics of the implant that could have influenced osseointegration. Further clinical trials are recommended to evaluate the performance of zirconia implants under loading conditions.

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Section: Introductionmentioning

confidence: 99%

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Siddiqi

Duncan

Silva

et al. 2016

BioMed Research International

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“…Pigs and sheep are suitable models for human bone studies with long-bone dimensions [46, 47] and structure [48, 49] that are similar to humans. Pigs have been shown to have similarities in bone remodeling [48] while sheep provide a comparable model for bone in growth into osteoconductive biomaterials [50].…”

Section: Introductionmentioning

confidence: 99%

Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs

Mumaw

Jordan

Sonnet

et al. 2012

International Journal of Biomaterials

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Autologous bone grafting is the most effective treatment for long-bone nonunions, but it poses considerable risks to donors, necessitating the development of alternative therapeutics. Poly(ethylene glycol) (PEG) microencapsulation and BMP2 transgene delivery are being developed together to induce rapid bone formation. However, methods to make these treatments available for clinical applications are presently lacking. In this study we used mesenchymal stem cells (MSCs) due to their ease of harvest, replication potential, and immunomodulatory capabilities. MSCs were from sheep and pig due to their appeal as large animal models for bone nonunion. We demonstrated that cryopreservation of these microencapsulated MSCs did not affect their cell viability, adenoviral BMP2 production, or ability to initiate bone formation. Additionally, microspheres showed no appreciable damage from cryopreservation when examined with light and electron microscopy. These results validate the use of cryopreservation in preserving the viability and functionality of PEG-encapsulated BMP2-transduced MSCs.

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“…However, a presence of irregular Haversian bone tissue was mentioned in antero-lateral sides only in our study. According to Newman et al [13] Haversian remodeling takes place in bones of adult sheep notably in the diaphysis of the radius. Therefore, irregular Haversian tissue could be found in our femora.…”

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confidence: 99%

Histological Analysis of Ovine Compact Bone Tissue

et al. 2007

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ABSTRACT. Histological sections of femoral diaphysis from adult sheep were investigated in this study. The qualitative characteristics in microstructure of the compact bone were examined in anterior, posterior, medial and lateral views; the quantitative ones were assessed using the software Scion Image. Areas, perimeters, minimum and maximum diameters of the Haversian canals, the Haversian systems and the primary osteons' vascular canals were measured. Our results indicate that ovine diaphysis of the femur is occupied mainly with primary vascular plexiform (laminar, fibrolamellar) tissue. In addition, irregular and dense Haversian bone tissues were observed. All measured variables disposed lower values in comparison with other artiodactyls (cattle and pig). KEY WORDS: compact bone, histomorphometry, sheep.

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The potential of sheep for the study of osteopenia: Current status and comparison with other animal models

Cited by 210 publications

References 35 publications

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs

Histological Analysis of Ovine Compact Bone Tissue

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