Introduction. The high level of morbidity and mortality from malignant neoplasms among the population is one of the pressing health problems. The aim of the study is to assess cancer risk according to the array of epidemiological indicators and identify risk zones in the Irkutsk region. Materials and methods. The work was carried out according to the official statistical reporting data. The analysis included 37 locations of malignant neoplasms under ICD-X. Data analysis was carried out in three stages using cluster analysis methods and relative risk assessment. Results. Two priority groups of risk areas have been identified. The highest levels of incidence, prevalence, and mortality are noted in cluster 1. Cluster 1 includes industrial cities with accumulated technogenic impact. 2 cluster includes mainly northern territories, where the highest level and growth of mortality, morbidity, morbidity and neglect are noted. Rural areas in the central part of the Irkutsk region, where the bulk of the Buryat population traditionally lives, are characterised by relatively low morbidity and mortality rates from malignant neoplasms. This feature determines the need for targeted research to identify protective genetic and environmental factors. Conclusion. Tested in this work, the three-stage approach to analysing epidemiological indicators of oncological pathology can be used to identify critical problems in other territories.