The Potential of Proton Therapy for Locally Advanced Breast Cancer: Clinical and Technical Considerations

Lalani, Nafisha; Alqarni, S.; Jimenez, Rachel

doi:10.3390/curroncol30030219

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Since the early 2000s, proton therapy was suggested as a promising technique for breast cancer treatment and several studies have shown potential benefits for toxicity reductions compared to radiotherapy using photons [10,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy

Bonaccorsi,

Tessonnier,

Hoeltgen

et al. 2024

Cancers

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Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks to a reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative treatment planning study involving ten patients, previously treated with VMAT (Volumetric Modulated Arc Therapy) for 50 Gy in 25 fractions for locally advanced, node-positive breast cancer, was carried out using proton pencil beam therapy with a fixed relative biological effectiveness (RBE) of 1.1 and helium therapy with a variable RBE described by the mMKM (modified microdosimetric kinetic model). Results indicated that target coverage was improved with particle therapy for both the clinical target volume and especially the internal mammary lymph nodes compared to VMAT. Median dose value analysis revealed that proton and helium plans provided lower dose on the left anterior descending artery (LAD), heart, lungs and right breast than VMAT. Notably, helium therapy exhibited improved ipsilateral lung sparing over protons. Employing NTCP models as available in the literature, helium therapy showed a lower probability of grade ≤ 2 radiation pneumonitis (22% for photons, 5% for protons and 2% for helium ions), while both proton and helium ions reduce the probability of major coronary events with respect to VMAT.

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Section: Introductionmentioning

confidence: 99%

Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy

Bonaccorsi,

Tessonnier,

Hoeltgen

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…In addition to inviting experts to review and resolve controversial themes for this Special Issue, we also solicited descriptions of innovative topics positioned at the vanguard of breast radiotherapy. Lalani et al discussed the potential of proton therapy in the management of locally advanced breast cancer [15]. These authors reviewed the unique physical characteristics of proton beams, which may constitute a distinct advantage when clinicians are beset by the need to encompass nodal basins and intricate reconstructions.…”

mentioning

confidence: 99%