The potential of phytochemical products in biofilm control

Andrade, Mafalda; Malheiro, Joana; Borges, Fernanda; Saavedra, María José; Simões, Manuel

doi:10.1016/b978-0-12-819497-3.00012-x

Cited by 6 publications

(4 citation statements)

References 96 publications

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“…In this case, the edtabz and Bi-edtabz do not present a direct correlation; thus, further investigation should be done to elucidate its antibiofilm mode of action. In this sense, studies focused on understanding the transition from planktonic free-living cells to complex bacterial communities in biofilms have been evidenced multiple factors involved in this process, such as the ability of bacteria to attach and colonize abiotic surfaces, the physicochemical properties of bacterial surface, the production of extracellular polymeric substances, and cell-to-cell communication (Borges et al, 2016;Andrade et al, 2020). These factors could be considered as starting points to get insight into the mode of action.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of bismuth(III) complex with an EDTA-based phenylene ligand and its potential as anti-virulence agent

Beltran-Torres

Sugich-Miranda

Santacruz‐Ortega

et al. 2022

PeerJ Inorganic Chemistry

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A new acyclic bismuth complex (Bi-edtabz) was synthesized from a mixture of solutions of the ligand (EDTA-based phenylene) and bismuth under acidic conditions. Its anti-virulence properties were evaluated against Escherichia coli O157: H7, Listeria monocytogenes, Pseudomonas aeruginosa, Salmonella enterica sub. enterica serovar Typhimurium and Staphylococcus aureus. The bismuth complex was characterized by NMR, UV-Vis, FTIR, ESI/MS and TG. Furthermore, Bi-edtabz complex at 0.25–1 mM presented better antibiofilm properties against E. coli O157: H7 and S. aureus with values of biomass reduction of 30.1–57.1% and 37.8–55.5%, respectively, compared with the ligand edtabz. While biofilm formation of L. monocytogenes, P. aeruginosa and Salmonella Typhimurium was most impaired by edtabz (biomass reduction of 66.1–100%, 66.4–88.0% and 50.9–67.1%), respectively. Additionally, Bi-edtabz inhibited the swimming motility of E. coli O157: H7 (12.5%) and colony spread of S. aureus (47.2%) at 1 mM and inhibited violacein production, a quorum-sensing related pigment of the biosensor strain Chromobacterium violaceum. Hence, edtabz and the Bi-edtabz complex can be used as novel anti-virulence agents against pathogenic bacteria.

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Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of bismuth(III) complex with an EDTA-based phenylene ligand and its potential as anti-virulence agent

Beltran-Torres

Sugich-Miranda

Santacruz‐Ortega

et al. 2022

PeerJ Inorganic Chemistry

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“…For instance, rutin can inhibit topoisomerase IV, whereas myricetin targets DnaB helicase. (−)‐Epigallocatechin, myricetin, and robinetin can inhibit P. vulgaris DNA synthesis and S. aureus RNA synthesis via B ring intercalation and/or hydrogen formation with the stacking of nucleic acid bases (Andrade et al., 2020). Berberine inhibits DNA intercalation and targets RNA polymerase, gyrase, and topoisomerase IV (Khameneh et al., 2019), whereas alkaloids, such as isoquinolines, target type I topoisomerase, thereby preventing the translation of AMR resistant genes (Mittal & Jaitak, 2019).…”

Section: Antimicrobial Mechanism Of Plant Byproduct Compoundsmentioning

confidence: 99%

Inhibitory mechanisms of promising antimicrobials from plant byproducts: A review

Qian

Ismail

et al. 2023

Comp Rev Food Sci Food Safe

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Plant byproducts and waste present enormous environmental challenges and an opportunity for valorization and industrial application. Due to consumer demands for natural compounds, the evident paucity of novel antimicrobial agents against foodborne pathogens, and the urgent need to improve the arsenal against infectious diseases and antimicrobial resistance (AMR), plant byproduct compounds have attracted significant research interest. Emerging research highlighted their promising antimicrobial activity, yet the inhibitory mechanisms remain largely unexplored. Therefore, this review summarizes the overall research on the antimicrobial activity and inhibitory mechanisms of plant byproduct compounds. A total of 315 natural antimicrobials from plant byproducts, totaling 1338 minimum inhibitory concentrations (MIC) (in μg/mL) against a broad spectrum of bacteria, were identified, and a particular emphasis was given to compounds with high or good antimicrobial activity (typically <100 μg/mL MIC). Moreover, the antimicrobial mechanisms, particularly against bacterial pathogens, were discussed in-depth, summarizing the latest research on using natural compounds to combat pathogenic microorganisms and AMR. Furthermore, safety concerns, relevant legislation, consumer perspective, and current gaps in the valorization of plant byproducts-derived compounds were comprehensively discussed. This comprehensive review covering up-to-date information on antimicrobial activity and mechanisms represents a powerful tool for screening and selecting the most promising plant byproduct compounds and sources for developing novel antimicrobial agents. K E Y W O R D S antimicrobial resistance, bacterial pathogens, inhibitory mechanisms, natural antimicrobial agents, plant byproducts Mengyan Qian and Balarabe B. Ismail contributed equally to this work.

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“…Organosulfur compounds: Organosulfur compounds derived from garlic (Allium sativum) such as allicin, ajoenes and diallyl sulphide, have shown antimicrobial activity against a vast range of pathogens [161][162][163]. These compounds also have been tested as antimicrobial wash for poultry meat to reduce the number of C. jejuni cells [81,82,163].…”

Section: Plant-derived Compoundsmentioning

confidence: 99%

Campylobacter Biofilms: Potential of Natural Compounds to Disrupt Campylobacter jejuni Transmission

Elgamoudi

Korolik

2021

IJMS

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Microbial biofilms occur naturally in many environmental niches and can be a significant reservoir of infectious microbes in zoonotically transmitted diseases such as that caused by Campylobacter jejuni, the leading cause of acute human bacterial gastroenteritis world-wide. The greatest challenge in reducing the disease caused by this organism is reducing transmission of C. jejuni to humans from poultry via the food chain. Biofilms enhance the stress tolerance and antimicrobial resistance of the microorganisms they harbor and are considered to play a crucial role for Campylobacter spp. survival and transmission to humans. Unconventional approaches to control biofilms and to improve the efficacy of currently used antibiotics are urgently needed. This review summarizes the use plant- and microorganism-derived antimicrobial and antibiofilm compounds such as essential oils, antimicrobial peptides (AMPs), polyphenolic extracts, algae extracts, probiotic-derived factors, d-amino acids (DAs) and glycolipid biosurfactants with potential to control biofilms formed by Campylobacter, and the suggested mechanisms of their action. Further investigation and use of such natural compounds could improve preventative and remedial strategies aimed to limit the transmission of campylobacters and other human pathogens via the food chain.

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The potential of phytochemical products in biofilm control

Cited by 6 publications

References 96 publications

Synthesis and characterization of bismuth(III) complex with an EDTA-based phenylene ligand and its potential as anti-virulence agent

Synthesis and characterization of bismuth(III) complex with an EDTA-based phenylene ligand and its potential as anti-virulence agent

Inhibitory mechanisms of promising antimicrobials from plant byproducts: A review

Campylobacter Biofilms: Potential of Natural Compounds to Disrupt Campylobacter jejuni Transmission

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