The potential of PCNA inhibition as a therapeutic strategy in cervical cancer

Wendel, Sebastian O.; Snow, Jazmine A.; Gu, Long; Banerjee, Nilam Sanjib; Malkas, Linda; Wallace, Nicholas A.

doi:10.1002/jmv.29244

Cited by 3 publications

(1 citation statement)

References 77 publications

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“…The proliferating cell nuclear antigen (PCNA) plays an important role in the initiation of cell proliferation (DNA replication and repairing), and it can be used to evaluate the cell proliferation status. 49,50 As seen in Fig. 6B, the positive rate of PCNA in the REPNs + US group was significantly lower, indicating that the tumor proliferation rate in the REPNs + US group had been strongly inhibited.…”

Section: Resultsmentioning

confidence: 85%

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Ren,

Yang,

Kong

et al. 2024

Nanoscale

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Section: Resultsmentioning

confidence: 85%

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Ren,

Yang,

Kong

et al. 2024

Nanoscale

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The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery

Simonsen,

Søgaard,

Olsen

et al. 2024

Cell. Mol. Life Sci.

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DNA replication is a tightly coordinated event carried out by a multiprotein replication complex. An essential factor in the bacterial replication complex is the ring-shaped DNA sliding clamp, β-clamp, ensuring processive DNA replication and DNA repair through tethering of polymerases and DNA repair proteins to DNA. β -clamp is a hub protein with multiple interaction partners all binding through a conserved clamp binding sequence motif. Due to its central role as a DNA scaffold protein, β-clamp is an interesting target for antimicrobial drugs, yet little effort has been put into understanding the functional interactions of β-clamp. In this review, we scrutinize the β-clamp structure and dynamics, examine how its interactions with a plethora of binding partners are regulated through short linear binding motifs and discuss how contexts play into selection. We describe the dynamic process of clamp loading onto DNA and cover the recent advances in drug development targeting β-clamp. Despite decades of research in β-clamps and recent landmark structural insight, much remains undisclosed fostering an increased focus on this very central protein.

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Anti-filarial efficacy of Centratherum anthelminticum: unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches

Kumar,

Mishra,

Singh

et al. 2024

RSC Adv.

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The potential of PCNA inhibition as a therapeutic strategy in cervical cancer

Cited by 3 publications

References 77 publications

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery

Anti-filarial efficacy of Centratherum anthelminticum: unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches

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The potential of PCNA inhibition as a therapeutic strategy in cervical cancer

Cited by 3 publications

References 77 publications

Integrin αvβ3-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin αvβ3-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery

Anti-filarial efficacy of Centratherum anthelminticum: unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches

Contact Info

Product

Resources

About

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer