The potential of methylsiloxanes as solvents for synthetic chemistry applications

Rani, Mohd Azri Ab; Borduas-Dedekind, Nadine; Colquhoun, Victoria; Hanley, Robert N.; Johnson, Henry; Larger, Solène; Lickiss, Paul D.; Llopis-Mestre, Verónica; Luu, Selina; Mogstad, Martin; Oczipka, Philipp; Sherwood, James; Welton, Tom; Xing, Jun Yi

doi:10.1039/c3gc42036a

Cited by 19 publications

(14 citation statements)

References 71 publications

(85 reference statements)

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“…A website has been built [ 77 ], which allows one to apply this methodology to solvents not originally included (e.g. when low molecular weight siloxanes [ 78 ] were proposed as replacements for non-polar solvents). The Pfizer selection guide does not try to give absolute measures, but makes relative judgements.…”

Section: ‘Green’ Solventsmentioning

confidence: 99%

Solvents and sustainable chemistry

2015

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Solvents are widely recognized to be of great environmental concern. The reduction of their use is one of the most important aims of green chemistry. In addition to this, the appropriate selection of solvent for a process can greatly improve the sustainability of a chemical production process. There has also been extensive research into the application of so-called green solvents, such as ionic liquids and supercritical fluids. However, most examples of solvent technologies that give improved sustainability come from the application of well-established solvents. It is also apparent that the successful implementation of environmentally sustainable processes must be accompanied by improvements in commercial performance.

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Section: ‘Green’ Solventsmentioning

confidence: 99%

Solvents and sustainable chemistry

2015

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“…Following a standard preparation [41], iodomethane (4.44 g, 31 mmol) was added dropwise to a stirred solution of trioctylamine (8.85 g, 25 mmol) in THF (100 mL), and the mixture was stirred at 40 • C for 12 h under a flow of N 2 . The crude mixture was concentrated under vacuum, diluted with diethyl ether (100 mL), and contacted three times with an aqueous solution of sodium nitrate (7 M) (1 h, room temperature).…”

Section: Synthesis Of Trioctylmethylammonium Nitrate (Il)mentioning

confidence: 99%

Understanding the Recovery of Rare-Earth Elements by Ammonium Salts

Hunter

Dolezalova

Ngwenya

et al. 2018

Metals

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While the recovery of rare earth elements (REEs) from aqueous solution by ionic liquids (ILs) has been well documented, the metal compounds that are formed in the organic phase remain poorly characterized. Using spectroscopic, analytical, and computational techniques, we provide detailed chemical analysis of the compounds formed in the organic phase during the solvent extraction of REEs by [(n-octyl) 3 NMe][NO 3 ] (IL). These experiments show that REE recovery using IL is a rapid process and that IL is highly durable. Karl-Fischer measurements signify that the mode of action is unlikely to be micellar, while ions of the general formula REE(NO 3) 4 (IL) 2 − are seen by negative ion electrospray ionization mass spectrometry. Additionally, variable temperature 139 La nuclear magnetic resonance spectroscopy suggests the presence of multiple, low symmetry nitrato species. Classical molecular dynamics simulations show aggregation of multiple ILs around a microhydrated La 3+ cation with four nitrates completing the inner coordination sphere. This increased understanding is now being exploited to develop stronger and more selective, functionalized ILs for REE recovery.

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“…Therefore a comprehensive safety datasheet should be enough to assess the greenness of a solvent using this approach. Indeed, this was attempted for volatile methyl siloxane solvents in a separate work [35]. However, since 2008 and the introduction of the Global Harmonized System (GHS) as applied by the European Classification, Labelling and Packaging (CLP) regulation [29], this method is in need of revision.…”

Section: Defining Green Solventsmentioning

confidence: 99%

Tools and techniques for solvent selection: green solvent selection guides

Byrne

Jin

Paggiola

et al. 2016

Sustain Chem Process

1,002

737

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Driven by legislation and evolving attitudes towards environmental issues, establishing green solvents for extractions, separations, formulations and reaction chemistry has become an increasingly important area of research. Several general purpose solvent selection guides have now been published with the aim to reduce use of the most hazardous solvents. This review serves the purpose of explaining the role of these guides, highlighting their similarities and differences. How they can be used most effectively to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry, is addressed in detail.

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The potential of methylsiloxanes as solvents for synthetic chemistry applications

Cited by 19 publications

References 71 publications

Solvents and sustainable chemistry

Solvents and sustainable chemistry

Understanding the Recovery of Rare-Earth Elements by Ammonium Salts

Tools and techniques for solvent selection: green solvent selection guides

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