The potential of Leucosidea sericea against Propionibacterium acnes

Sharma, Richa; Kishore, N.; Hussein, Ahmed A.; Lall, Namrita

doi:10.1016/j.phytol.2013.11.005

Cited by 27 publications

(17 citation statements)

References 23 publications

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“…The anti-acne assay achieved inhibitory activity at 3.90-31.25 µg mL −1 which is comparable to previous reports by Sharma et al (2014) at a MIC value of 15.62 µg mL −1 . Better activity was, however, obtained in the colder seasons namely autumn and winter ( Table 1).…”

Section: Resultssupporting

confidence: 88%

“…Leucosidea sericea was previously identified as a plant with good activity against P. acnes at 15.62 µg mL −1 and the isolated active compound α-kosin with an MIC value of 1.95 µg mL −1 (Sharma et al, 2014). Additionally 3,5,7,3 ,4 -pentahydroxyflavone was recently isolated from the methanol leaf extract of L. sericea with significant broad-spectrum antibacterial activity at 1.95-125 µg mL −1 (Pendota et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…It is commonly known as "oldwood" (English), "ouhout" (Afrikaans), and "umTshitshi" in Zulu, and traditionally used as a charm to protect the inhabitants of homesteads, treat various ailments such as opthalmia and intestinal worm infection, used as a vermifuge and astringent. The antioxidant, anti-inflammatory, acetylcholinesterase inhibitory activity and mutagenic activities have been investigated in different studies, although the cosmeceutical application is poorly researched with a single report on the anti-acne activity (Aremu et al, 2010;Sharma et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, bacterial resistance is a continuous challenge and plants therefore provide various opportunities to find new anti-acne agents (Chomnawang et al, 2007;Tsai et al, 2010;Sinha et al, 2014). The anti-acne activity for L. sericea was reported with a MIC value of 15.62 µg mL −1 and the isolated active compound α-kosin with an MIC value of 1.95 µg mL −1 (Sharma et al, 2014), and therefore presents and opportunity as an anti-acne cosmeceutical.…”

Section: Introductionmentioning

confidence: 99%

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1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

2020

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Leucosidea sericea is an evergreen shrub belonging to the Rosaceae family with previous studies that indicated that L. sericea extracts exhibited strong anti-bacterial properties against Propionibacterium acnes, showing potential as a cosmeceutical. The plant is traditionally used as a vermifuge, as an astringent and to treat conjunctivitis. Commercial production is, however, not possible as no information is available on cultivation and the effect of external environmental factors such as seasonal variation on the medicinal properties of the plant. Seasonal variation was investigated and it was found that significant differences were observed between the anti-acne (P. acnes) activity of plant material collected in different seasons. The best activity was found in winter with a mean minimum inhibitory concentration (MIC) of 5.20 µg mL −1 compared to spring at 26.04 µg mL −1. A 1 H NMR-based untargeted metabolomic analysis was used to determine the differences in the chemical profiles of plant samples collected in different seasons. Principal component analysis (PCA) showed clear separation of the seasons and a supervised orthogonal partial least square discriminant analysis (OPLS-DA) was used to determine the compounds that differentiated the spring from the winter samples. The contribution plot indicated a strong positive association with the NMR regions from δ 1.2-1.6, 3.3-4.1, and 6.8-8.0 ppm indicative of a compound with an aromatic ring. Different LC-MS analyses were used in conjunction with a compound database, MAGMa and CSIFingerID, which led to the identification of the compound 2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one and also confirmed the presence of tangeritin, rutin, quercetin glucoside, and kaempferol glucosides as well as several other compounds previously identified from the plant. This compound similar in structure to the anti-microbial flavonoid tangeritin, was only present in the winter samples. It is therefore recommended that seasonal variation be closely monitored during cultivation and commercial harvesting, and that winter is the preferred harvesting season to obtain the best anti-acne activity.

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Section: Resultssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

2020

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“…Traditionally, it is used as protection against charm, vermifuge, astringent, for expelling parasitic worms and as a treatment for ophthalmia [66,67]. Extracts from this economic plant have been prepared from different solvents and have shown anti-inflammatory, antioxidant, antiparasitic, antimicrobial, anthelmintic, antibacterial, antiacne and acetylcholinesterase inhibitory activities [64,[67][68][69][70]. A hand full of active compounds have been identified and isolated from L. sericea including triterpenes [66] and phloroglucinols [70].…”

mentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

et al. 2020

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In this study, procyanidins fractions of dimers and trimers (F1-F2) from the Leucosidea sericea total extract (LSTE) were investigated for their chemical constituents. The total extract and the procyanidins were employed in the synthesis of gold nanoparticles (Au NPs) and fully characterized. Au NPs of 6, 24 and 21 nm were obtained using LSTE, F1 and F2 respectively. Zeta potential and in vitro stability studies confirmed the stability of the particles. The enzymatic activity of LSTE, F1, F2 and their corresponding Au NPs showed strong inhibitory alpha-amylase activity where F1 Au NPs demonstrated the highest with IC 50 of 1.88 µg/mL. On the other hand, F2 Au NPs displayed the strongest alpha-glucosidase activity at 4.5 µg/mL. F2 and F2 Au NPs also demonstrated the highest antioxidant activity, 1834.0 ± 4.7 µM AAE/g and 1521.9 ± 3.0 µM TE/g respectively. The study revealed not only the ability of procyanidins dimers (F1 and F2) in forming biostable and bioactive Au NPs but also, a significant enhancement of the natural products activities, which could improve the smart delivery in future biomedical applications.Biomolecules 2020, 10, 452 2 of 24 applying nanoparticles through the green route is their biocompatibility [5]. Many green synthesized nanoparticles have demonstrated interesting biological activities [5,10] including antimicrobial and antidiabetic properties.Diabetes mellitus has undoubtedly become a serious health challenge. More worrisome is type II diabetes mellitus (T2DM), which accounts for 90% of diabetes mellitus. It occurs as a result of the inefficient processing of insulin [11]. As of 2017, the population of adults between the ages of 20 and 79 that suffered from diabetes was 425 million [12]. This is equivalent to 9.9% of the world's population [12]. By estimation, this disease would have drastically increased by 48% in 28 years if not properly managed [13]. Although drugs like miglitol, vigliobose as well as acarbose are available in the market, they are costly and their continuous use is associated with side effects like diarrhea, dropsy, heart failure, damage to the liver, weight gain, abdominal pain, hyperglycemia, and flatulence, necessitating the need for more potent and newer remedies [14][15][16].It is well established that bioactive compounds in various plants possess significant effects in delaying and management of T2DM [17]. Extracts from different plants have been reported as alpha-glucosidase and alpha-amylase inhibitors [18][19][20][21][22][23][24][25][26][27]. Additionally, biologically synthesized Au NPs using plant extracts showed interesting antidiabetic activity. The extracts of Chamalcostus cuspidatus [28], Gymnema sylvestre [29], Cassia fistula stem bark [30], Hericium erinaceus [31], Turbinaria conoides [32], Sambucus nigra [33] and Sargassum swartzi [34] displayed antidiabetic activities in various investigations. Silver/gold NPs of Ocimum basilicum [35] and cinnamon extract [36] also lowers glucose levels. The use of single molecules as reducing/stabilizing agents for ...

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