The Potential of Ganoderma Lucidum as Antimicrobial Agent for Multidrug- Resistant Mycobacterium Tuberculosis

Abstract

Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro. Methods: This study used a solid dilution method to test the extract of G. lucidum as an antibacterial agent. Results and Conclusion: Results showed that all strains of multidrug-resistant tuberculosis (MDR-Tb) gave similar responses to G. lucidum extract at various concentrations. The bacteria did not grow on the medium containing G. lucidum extract at the smallest concentration of 12.5%, as well as concentrations of 25% and 50%. Ganoderma lucidum can be used as one of the alternatives for MDR-Tb drugs in the future.

Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

“…To detect whether G. lucidum acted on drug resistance, multidrug-resistant tuberculosis was considered. After administration of G. lucidum extracts in different concentrations, the growth of tuberculosis was inhibited [261]. In addition, extended-spectrum β-lactamase-producing and multidrug-resistant…”

Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites

“…G. lucidum has been shown to possess potent antimicrobial activity against a variety of bacteria, viruses, and fungi [ 92 ]. There are several potential future developments for G. lucidum as an antimicrobial agent that could be possible, such as the development of new antibiotics, natural preservatives, bioremediation, and personal care products [ 2 , 197 ]. Overall, the antimicrobial properties of G. lucidum suggest that it has promising future prospects as a natural source of antimicrobial agents.…”

Vol 14 NO. 2 (2024)

“…The number of articles per year relative to apple pomace utilization for obtaining triterpene acids has increased greatly in the last decade. Currently, the extraction methods of triterpene acids include different techniques such as Soxhlet extraction [12], heat reflux extraction, microwave-assisted extraction, accelerated solvent extraction [13] and supercritical fluid extraction [14]. Various methods of increasing interest for determining and obtaining triterpene acids from apple reprocessing materials and other plant resources can be found and reviewed.…”