The potential of digital health technologies in African context, Ethiopia

Manyazewal, Tsegahun; Woldeamanuel, Yimtubezinash; Blumberg, Henry M.; Fekadu, Abebaw; Marconi, Vincent C.

doi:10.1101/2021.03.27.21254466

Cited by 2 publications

(1 citation statement)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heterogeneity among the included studies was assessed by inspecting the forest plots and the Cochrane Q and I 2 statistic used to measure heterogeneity among the trials in each analysis, the Chi 2 test with a P < 0.10 to indicate statistical significance was used. The results were interpreted following Cochrane Handbook for Systematic Reviews of Interventions Version 6.0 (36). Subgroup analysis was done by dividing the studies into two groups based on the year when the studies were conducted.…”

Section: Data Management and Statistical Analysismentioning

confidence: 99%

Prevalence of cryptococcal meningitis among people living with human immuno-deficiency virus and predictors of mortality in adults on induction therapy in Africa: A systematic review and meta-analysis

et al. 2022

Self Cite

View full text Add to dashboard Cite

BackgroundCryptococcal meningitis (CM) is a leading cause of adult meningitis in countries with a high burden of HIV. It has remained a significant cause of morbidity and mortality in Africa despite the extensive rollout of HIV antiretroviral therapy (ART). This study aimed to systematically synthesize the evidence on the prevalence of CM among people living with HIV (PLWH) and its predictors of mortality among adults who are on induction antifungal therapy in Africa.MethodsPubMed/MEDLINE, Embase, and Google Scholar were searched for randomized clinical trials or observational studies published in Africa from 1995 to April 2021. Pooled prevalence of CM among PLWH was calculated using R-studio Version 1.4.1717 software and the data extracted from eligible studies were pooled as percentage with a 95% confidence interval (CI). Predictors of mortality among adults on induction antifungal therapy were synthesized narratively.ResultsOut of 364 studies identified, 17 eligible articles were included in the analysis. The prevalence of CM among PLWH in Africa was 5.11% (95% CI 2.71–9.43%; participants = 10,813; studies = 9; I2 = 97%). In the subgroup analysis, the prevalence was 12.9% (95% CI 4.883–30.0; participants = 533; studies = 3; I2 = 63%) in the years 1995–2010 and 3.18% (95% CI 1.54–6.45; participants = 10,280; studies = 6; I2 = 98%) in the years 2011–2021, with the prevalence significantly decreased by 51% (p = 0.02). Predictors of mortality were fluconazole monotherapy, focal neurological signs, low Glasgow coma scale, and delayed diagnosis of CM at varied timepoint.ConclusionPrevalence of CM has significantly decreased from 1996–2010 to 2011–2021 among PLWH on induction therapy in Africa. Fluconazole monotherapy, focal neurological symptoms, diastolic blood pressure < 60 mmHg, and concurrent tuberculosis coinfection were significant predictors of mortality at 2- and 10-weeks timepoints. CM remains a major concern among PLWH despite increases in ART coverage. Improved access to effective antifungal therapies is needed in Africa for timely initiation of combination induction therapy and better treatment outcomes of PLWH.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=254113], identifier [CRD42021254113].

show abstract

Section: Data Management and Statistical Analysismentioning

confidence: 99%

Prevalence of cryptococcal meningitis among people living with human immuno-deficiency virus and predictors of mortality in adults on induction therapy in Africa: A systematic review and meta-analysis

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Spatiotemporal modeling of under-five mortality and associated risk factors in Ethiopia using 2000–2016 EDHS data

Amuka,

Mitiku,

Zeru

2024

BMC Pediatr

View full text Add to dashboard Cite

Background The under-five mortality rate serves as a key indicator of the performance of a country’s healthcare system. Despite a minor decline, Ethiopia continues to face a persistently high under-five mortality rate across different zones. Thus, this study aimed to identify the risk factors of under-five mortality and the spatiotemporal variation in Ethiopian administrative zones. Method This study used the 2000–2016 Ethiopian Demographic and Health Survey (EDHS) data which were collected using a two-stage sampling method. A total of 43,029 (10,873 in 2000, 9,861 in 2005, 11,654 in 2011, and 10,641 in 2016) weighted sample under-five child mortality were used. The space-time dynamic model was employed to account for spatial and time effects in 65 administrative zones in Ethiopia. Results From the result of a general nesting spatial-temporal dynamic model, there was a significant space-time interaction effect [γ = -0.1444, 95% CI(-0.6680, -0.1355)] for under-five mortality. The increase in the percentages of mothers illiteracy [β = 0.4501, 95% CI (0.2442, 0.6559)], not vaccinated[β= 0.7681, 95% CI (0.5683, 0.9678)], unimproved water[β= 0.5801, CI (0.3793, 0.7808)] were increased death rates for under five children while increased percentage of contraceptive use [β= -0.6609, 95% CI (-0.8636, -0.4582)] and antenatal care unit visit > 4 times [β= -0.1585, 95% CI(-0.1812, -0.1357)] were contributed to the decreased under-five mortality rate at the zone in Ethiopia. Conclusions Even though the mortality rate for children under five has decreased over time, still there is higher in different zones of Ethiopia. There exists spatial and temporal variation in under-five mortality among zones. Therefore, it is very important to consider spatial neighborhood’s and temporal context when aiming to avoid under-five mortality.

show abstract

The potential of digital health technologies in African context, Ethiopia

Cited by 2 publications

References 95 publications

Prevalence of cryptococcal meningitis among people living with human immuno-deficiency virus and predictors of mortality in adults on induction therapy in Africa: A systematic review and meta-analysis

Prevalence of cryptococcal meningitis among people living with human immuno-deficiency virus and predictors of mortality in adults on induction therapy in Africa: A systematic review and meta-analysis

Spatiotemporal modeling of under-five mortality and associated risk factors in Ethiopia using 2000–2016 EDHS data

Contact Info

Product

Resources

About