The Potential of CRISPR-Guided Therapies in the Dermatology Clinic

Bhat, Prashant; Garibyan, Lilit

doi:10.1016/j.xjidi.2022.100103

Cited by 4 publications

(6 citation statements)

References 65 publications

(87 reference statements)

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“…This synergy harnesses CRISPR's precision in gene editing to specifically target aging-related genes, complemented by the supportive properties of marine collagen. The result is an innovative approach with enhanced therapeutic effects, particularly in skin elasticity and hydration [30]. The findings lay the groundwork for the development of revolutionary anti-aging collagen treatments derived from underexplored marine organisms.…”

Section: Introductionmentioning

confidence: 93%

“…It might also offer a tool for curing genetically based diseases [46]. Dermatological applications of CRISPR technology have been highly promising [30,47,48]. Despite there being no direct research on using CRISPR technology on marine collagen, the integration of these two fields could potentially lead to effective anti-aging treatments.…”

Section: The Integration Of Crispr Technology With Marine Collagenmentioning

confidence: 99%

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Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

Rahman,

Rehmani,

Pirvu

et al. 2024

Marine Drugs

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Aging is closely associated with collagen degradation, impacting the structure and strength of the muscles, joints, bones, and skin. The continuous aging of the skin is a natural process that is influenced by extrinsic factors such as UV exposure, dietary patterns, smoking habits, and cosmetic supplements. Supplements that contain collagen can act as remedies that help restore vitality and youth to the skin, helping combat aging. Notably, collagen supplements enriched with essential amino acids such as proline and glycine, along with marine fish collagen, have become popular for their safety and effectiveness in mitigating the aging process. To compile the relevant literature on the anti-aging applications of marine collagen, a search and analysis of peer-reviewed papers was conducted using PubMed, Cochrane Library, Web of Science, and Embase, covering publications from 1991 to 2024. From in vitro to in vivo experiments, the reviewed studies elucidate the anti-aging benefits of marine collagen, emphasizing its role in combating skin aging by minimizing oxidative stress, photodamage, and the appearance of wrinkles. Various bioactive marine peptides exhibit diverse anti-aging properties, including free radical scavenging, apoptosis inhibition, lifespan extension in various organisms, and protective effects in aging humans. Furthermore, the topical application of hyaluronic acid is discussed as a mechanism to increase collagen production and skin moisture, contributing to the anti-aging effects of collagen supplementation. The integration of bio-tissue engineering in marine collagen applications is also explored, highlighting its proven utility in skin healing and bone regeneration applications. However, limitations to the scope of its application exist. Thus, by delving into these nuanced considerations, this review contributes to a comprehensive understanding of the potential and challenges associated with marine collagen in the realm of anti-aging applications.

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Section: Introductionmentioning

confidence: 93%

Section: The Integration Of Crispr Technology With Marine Collagenmentioning

confidence: 99%

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

Rahman,

Rehmani,

Pirvu

et al. 2024

Marine Drugs

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“…143 Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR associated (Cas) nucleases is one technology that holds promise for patients with inflammatory skin disease. 144 The technology is introduced in vivo into target cells by viral vector-based methods. 145 CRIPSR/Cas has enabled editing of specific genetic targets and transcripts, that is DNA and RNA.…”

Section: Therapeutic Implications Of Ethnic and Geographic Variations...mentioning

confidence: 99%

Increased loss‐of‐function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta‐analysis

Khatib,

Klein‐Petersen,

Rønnstad

et al. 2024

Experimental Dermatology

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Loss‐of‐function (LoF) mutations in the filaggrin gene (FLG) constitute the strongest genetic risk for atopic dermatitis (AD). A latitude‐dependent difference in the prevalence of LoF FLG mutations was systematically evaluated. A systematic review and meta‐analysis were performed to estimate the prevalence of LoF FLG mutations in AD patients and the general population by geography and ethnicity. Risk of bias was assessed by Newcastle‐Ottawa Scale and Jadad score. StatsDirect, version 3 software was used to calculate all outcomes. PubMed and EMBASE were searched until 9th December 2021. Studies were included if they contained data on the prevalence of LoF FLG mutations in AD patients or from the general population or associations between AD and LoF FLG mutations and were authored in English. Overall, 248 studies and 229 310 AD patients and individuals of the general population were included in the quantitative analysis. The prevalence of LoF FLG mutations was 19.1% (95% CI, 17.3–21.0) in AD patients and 5.8% (95% CI, 5.3–6.2) in the general population. There was a significant positive association between AD and LoF FLG mutations in all latitudes in the Northern hemisphere, but not in all ethnicities. The prevalence of LoF FLG mutations became gradually more prevalent in populations residing farther north of the Equator but was negligible in Middle Easterners and absent in most African populations. FLG LoF mutations are common and tend to increase with northern latitude, suggesting potential clinical implications for future AD management. The existence of possible genetic fitness from FLG LoF mutations remains unknown.

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“…In addition to targeting mutated ERVs in keratinocytes' progenitor cells, and perhaps even in endothelial cells, possibly using gene medicines such as CRISPER-guided therapies targeting mutations 122 , future therapies could also consider reprogramming progenitor cells by means of tissue microbiome modifications. To this end, alterations in the skin and intestinal microbiome play a critical role in psoriasis 123 .…”

Section: Future Directionsmentioning

confidence: 99%

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

Rezabakhsh,

Manjili,

Hosseinifard

et al. 2023

Preprint

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Current treatments are ineffective to cure or prevent occurrences of autoimmune psoriasis and psoriatic cardiovascular disease/CVD. Psoriasis is associated with deregulated expressions of human endogenous retroviruses (ERVs) variants. ERV transcripts and proteins are detected in lesioned biopsies—without assembled viral particles—in addition to antibody and T-cell responses against ERV-K dUTPase. In persons living with HIV-1, manifestations of psoriasis are exacerbated variably. These may depend on multiple factors, differences in ERVs expressions, subtypes of HIV-1, and/or epigenetics. This article represents a quantitative risk assessment and meta-analysis approach with an attempt to assess causality. We surmise that mutated ERVs trigger aberrant proliferation and differentiation of keratinocytes, which in turn induce proinflammatory polarization. Independent risk factors and/or covariates with a range of relative risk/RR ratios appear to significantly impact the development of autoimmune psoriasis or immune intolerance, plausibly through ERVs genes activity. Given the antihypertensive drug’s potential in psoriasis development, a probable role in promising either ERVs activation or perturbations in epigenetic factors is questionable. Although the correlational nature of the data based on RR ratios prevents making robust conclusions, we reckon that the likelihood of attributable risk factors for certain antihypertensive drugs may stem from their pleiotropic effects or potentials for inducing ERV-mediated dysregulation of keratinocytes and/or endothelial cells. These findings expand our knowledge regarding ERV activations and HIV-1, antihypertensive drugs use, and incidents of psoriatic disease, and call for exploring cell-specific therapies aimed at blocking or reversing mutated ERVs gene activity toward attaining stable remissions in psoriasis and associated CVD.

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The Potential of CRISPR-Guided Therapies in the Dermatology Clinic

Cited by 4 publications

References 65 publications

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

Increased loss‐of‐function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta‐analysis

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

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