The potential of cod hydrolyzate to inhibit blood pressure in spontaneously hypertensive rats

Jensen, Ida‐Johanne; Eysturskarð, Jonhard; Madetoja, Mari; Eilertsen, Karl‐Erik

doi:10.1016/j.nutres.2013.11.003

Cited by 19 publications

(24 citation statements)

References 16 publications

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“…The results suggest that the increasing inhibition with the time of proteolysis is likely due to the accumulation of biological active peptides. This is in concordance with previous reports of ACE-inhibitory activities identified in muscle and by-products of fish such as Alaska pollock, blue whiting and cod (Byun and Kim, 2001; Dragnes et al, 2009b; Geirsdottir et al, 2011; Jensen et al, 2014). The determined IC50 values reflect that the ACE-inhibitory activity was measured directly in the hydrolysates without any further concentration by e.g freeze drying of the peptides.…”

Section: Resultssupporting

confidence: 93%

“…The determined IC50 values reflect that the ACE-inhibitory activity was measured directly in the hydrolysates without any further concentration by e.g freeze drying of the peptides. This is evident from the results in Table 5 reporting a higher protein concentration in μg/ml needed to reach the IC50 compared to previous reports based on analysis of freeze dried hydrolysates (Byun and Kim, 2001; Dragnes et al, 2009b; Geirsdottir et al, 2011; Jensen et al, 2014). However, the main purpose of the measurement was fulfilled as the result demonstrate that biological activity is retained despite the multiple thermal treatments of raw-material proteins during the processing to WFM.…”

Section: Resultsmentioning

confidence: 53%

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Nutritional and functional properties of fishmeal produced from fresh by-products of cod ( Gadus morhua L .) and saithe ( Pollachius virens )

Ween

Stangeland

Fylling

et al. 2017

Heliyon

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Fresh by-products of whitefish such as cod and saithe is processed to fishmeal (FM) on-board seagoing Norwegian trawlers. The aim of this study was to document the properties of whitefish FM (WFM) protein with respect to, physicochemical and bioactive properties. Analysis of the proximate composition of representative seasonal WFM batches show that the production is robust without much variance. The mean protein (61.9 ± 1.2), fat (8.9 ± 1.1%), moisture (5 ± 1.2%) and ash content (22.4 ± 0.8%), reflect the use of lean and bony raw-material. The WFM has a low content of free amino acids (0.7%) and biogenic amines (< 1000 mg/kg) that confirm the high quality and freshness of the raw material. Amino-acid analysis identified the presence of all nutritionally essential amino acids. The WFM physicochemical properties was comparable to soy-bean meal (SBM) by analysis of solubility, water-holding capacity (WHC), the emulsion stability (ES). Proteolytic degradation of the WFM was used to demonstrate the presence of bioactive peptides with inhibiting activity against angiotensin-converting enzyme (ACE) activity, in vitro. Taken together, WFM produced from fresh by-products is an excellent protein source with attributes of interest beyond the aquafeed-market.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 53%

Nutritional and functional properties of fishmeal produced from fresh by-products of cod ( Gadus morhua L .) and saithe ( Pollachius virens )

Ween

Stangeland

Fylling

et al. 2017

Heliyon

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show abstract

“…Renin (produced in the kidney) converts angiotensinogen (in the liver) to a decapeptide, angiotensin I, which is biologically inactive, but activated by conversion to angiotensin II (a major vasoconstrictor) by angiotensin‐converting enzyme (ACE). Persistent high blood pressure results from uncontrolled release of angiotensin II, and is a controllable risk factor for cardiovascular diseases such as stroke and heart failure, which are the leading causes of death and disability worldwide (Jensen, Eysturskarö, Madetoja, & Eilertsen, ). Inhibition of enzymes in the RAS pathway, especially ACE, is regarded to be a potent therapeutic approach in the treatment of hypertension (Lin, Lv, & Li, ).…”

Section: Introductionmentioning

confidence: 99%

“…Persistent high blood pressure results from uncontrolled release of angiotensin II, and is a controllable risk factor for cardiovascular diseases such as stroke and heart failure, which are the leading causes of death and disability worldwide (Jensen, Eysturskarö, Madetoja, & Eilertsen, 2014). Inhibition of enzymes in the RAS pathway, especially ACE, is regarded to be a potent therapeutic approach in the treatment of hypertension (Lin, Lv, & Li, 2012).…”

mentioning

confidence: 99%

Antioxidant properties, ACE/renin inhibitory activities of pigeon pea hydrolysates and effects on systolic blood pressure of spontaneously hypertensive rats

Olagunju

Omoba

Enujiugha

et al. 2018

Food Science & Nutrition

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Legumes are rich sources of protein in human diet and their consumption has been associated with the prevention of chronic diseases attributable to their bioactive components. Pigeon pea (Cajanus cajan) is an underutilized legume with relatively high protein content (~24%). Protein hydrolysates were prepared from pea isolate by enzymatic hydrolysis using pepsin and pancreatin. Hydrolysates were evaluated for their amino acid composition, antioxidant properties, in vitro and in vivo antihypertensive properties. The hydrolysates had high hydrophobic amino acids, especially isoleucine, phenylalanine, and leucine. Pepsin‐pancreatin‐hydrolyzed pea protein (PPHPp) showed significantly higher ability to scavenge DPPH˙ while pancreatin‐hydrolyzed pea protein (PPHPa) had higher ˙OH, ABTS˙+ scavenging, Fe3+ reducing and linoleic acid peroxidation inhibition. PPHPp exhibited superior angiotensin‐converting enzyme inhibition (61.82%) while PPHPa showed higher renin inhibition (14.28%). PPHPp exhibited strong antihypertensive effect, showing an instantaneous systolic blood pressure lowering effect (−26.12 mmHg) within 2‐h post‐oral administration. Pigeon pea protein hydrolysate (especially from pancreatin digest) could therefore, be a promising source of bioactive peptides and potential ingredient for formulation of functional foods against oxidative stress and hypertension.

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“…SHR have been administered daily over a period of four weeks with the hydrolysates in different dosages, resulting in significantly lowered blood pressure, even comparable to that of captopril. Hydrolysates of cod, haddock and salmon did not significantly reduce blood pressure in SHR during a four-week study [85], although the blood pressure in the group treated with cod hydrolysate did not increase after day 7. Fish has also been evaluated as part of the feed itself.…”

Section: Hypertensionmentioning

confidence: 99%

Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides—A Review

Jensen¹,

Mæhre²

2016

Marine Drugs

Self Cite

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High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, these proteins are sources for bioactive peptides with documented favorable physiological effects such as antioxidative, antihypertensive and other cardioprotective effects. This documentation is mainly from in vitro studies, but also animal studies are arising. Evidence from human studies evaluating the positive health effects of marine proteins and peptides are scarce. In one study, a reduction in oxidative stress after intake of cod has been documented and a few human clinical trials have been performed evaluating the effect on blood pressure. The results are, however, inconclusive. The majority of the human clinical trials performed to investigate positive health effects of marine protein and lean fish intake, has focused on blood lipids. While some studies have documented a reduction in triglycerides after intake of lean fish, others have documented no effects.

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The potential of cod hydrolyzate to inhibit blood pressure in spontaneously hypertensive rats

Cited by 19 publications

References 16 publications

Nutritional and functional properties of fishmeal produced from fresh by-products of cod ( Gadus morhua L .) and saithe ( Pollachius virens )

Nutritional and functional properties of fishmeal produced from fresh by-products of cod ( Gadus morhua L .) and saithe ( Pollachius virens )

Antioxidant properties, ACE/renin inhibitory activities of pigeon pea hydrolysates and effects on systolic blood pressure of spontaneously hypertensive rats

Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides—A Review

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