The Potential of circRNA as a Novel Diagnostic Biomarker in Cervical Cancer

Chen, Shuying; Yang, Xiuyan; Yu, Chengxuan; Zhou, Wenhan; Xia, Qiuyi; Liu, Ying; Chen, Qiudan; Chen, Xiaotong; Yuan, Liang; Yan, Lin

doi:10.1155/2021/5529486

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…Dysregulated expression of circRNAs has been systematically explored in cervical cancer 100 , 101 , which is one of the most malignant forms of cancer in females 102 . Multiple studies have also highlighted the roles of these circRNAs as potential diagnostic markers in cervical cancer 103 , 104 . circRNA hsa_circ_0023404 has been reported to mediate tumor formation.…”

Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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The Hippo signaling pathway is an evolutionarily conserved network that regulates organ size and tissue homeostasis in mammals. This pathway controls various cell functions, such as growth, proliferation, survival, apoptosis, and stemness by switching 'on' or 'off' its inhibitory and/or transcriptional module, thereby regulating target gene(s) expression. Altered Hippo signaling has been implicated in various forms of cancers. Increasing evidence suggests cross-talk between the Hippo signaling pathway and non-coding RNAs, in particular circular RNAs (circRNAs). In this context, the current review presents the mechanistic interplay between the Hippo pathway and related circRNAs in various forms of cancers, along with the capabilities of these circRNAs to function either as tumor suppressors or oncogenes through miRNA sponging or protein binding mechanisms. Furthermore, we discuss the constraints and limitations in circRNA mechanistic studies while highlighting some outstanding questions regarding the roles of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, we delineate the potential of these circRNAs to be employed as diagnostic and prognostic biomarkers, as well as molecular hotspots for cancer therapy.

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Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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“… 217 , 223 They lack protein encoding capacity and they have a closed loop structure. 224 Recent studies have revealed the role of circRNAs in HCC. A variety of molecular pathways including miRNAs, Raf1, PDK1 and RAB1A are modulated by circRNAs in HCC.…”

Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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“…In recent years, with the rapid development of bioinformatic analysis and RNA sequencing technologies, the crucial regulatory role of circRNAs has been explored in a series of tumors. [22][23][24] Chen et al found that circCAMSAP1 expression markedly increased within human OSA cells and tissue, which was closely related to OSA progression. 25 More recently, Qiu et al 26 established a circRNA-miRNA-mRNA network in OSA, in which four mRNAs were suggested as the overall survival-related mRNAs according to survival analysis.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma

Gu¹,

Duan²,

Liu³

et al. 2021

CMAR

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Introduction Osteosarcoma (OSA) is characterized by its relatively high morbidity in children and adolescents. Patients usually have advanced disease at the time of diagnosis, resulting in poor outcomes. This study focused on building a circular RNA-based ceRNA network to develop a reliable model for OSA risk prediction. Methods We used the Gene Expression Omnibus (GEO) datasets to explore the expression patterns of circRNA, miRNA, and mRNA in OSA. The prognostic value of circRNA host genes was assessed with data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database using Kaplan–Meier survival analysis. We established a circRNA-related ceRNA network and annotated its biological functions. Next, we developed a prognostic risk signature based on mRNAs extracted from the ceRNA network. We also developed a prognostic model and constructed a nomogram to enhance the prediction of OSA prognosis. Results We identified 166 DEcircRNAs, 233 DEmiRNAs, and 1317 DEmRNAs and used them to create a circRNA-related ceRNA network. We then established a prognostic risk model consisting of four genes (MLLT11, TNFRSF11B, SLC7A7, and PARVA). Moreover, we found that inhibition of MLLT11 and SLC7A7 blocked OSA cell proliferation and migration in in vitro experiments. Conclusion Our study identifies crucial prognostic genes and provides a circRNA-related ceRNA network for OSA, which will contribute to the elucidation of the molecular mechanisms underlying the oncogenesis and development of OSA.

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The Potential of circRNA as a Novel Diagnostic Biomarker in Cervical Cancer

Cited by 20 publications

References 23 publications

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma

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