The potential of bacterial cultures to degrade the mutagen 2-methyl-1,4-dinitro-pyrrole in a processed meat model

Motta, Gabriel Emiliano; Molognoni, Luciano; Daguer, Heitor; Angonese, Mariana; Lemos, Ana Lucia da Silva Correa; Dafre, Alcir Luiz; Lindner, Juliano De Dea

doi:10.1016/j.foodres.2020.109441

Food Research International

2020

DOI: 10.1016/j.foodres.2020.109441

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The potential of bacterial cultures to degrade the mutagen 2-methyl-1,4-dinitro-pyrrole in a processed meat model

Gabriel Emiliano Motta

Luciano Molognoni

Heitor Daguer

et al.

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Cited by 3 publications

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“…Increase antimutagenic activity [52,71,72]-Although this capability has largely been explored in the context of cancer [73], certain species of lactic acid microbiota can bind potent mutagens such as pyrolyzates [74,75] and heterocyclic amines [76,77] in the gut to decrease the mutagenic activity of these compounds. Reducing DNA damage reduces inflammation, protects the gut wall, increases mineral absorption, and suppresses osteoporosis [78].…”

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The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Seely

Kotelko

Douglas

et al. 2021

IJMS

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An expanding body of research asserts that the gut microbiota has a role in bone metabolism and the pathogenesis of osteoporosis. This review considers the human gut microbiota composition and its role in osteoclastogenesis and the bone healing process, specifically in the case of osteoporosis. Although the natural physiologic processes of bone healing and the pathogenesis of osteoporosis and bone disease are now relatively well known, recent literature suggests that a healthy microbiome is tied to bone homeostasis. Nevertheless, the mechanism underlying this connection is still somewhat enigmatic. Based on the literature, a relationship between the microbiome, osteoblasts, osteoclasts, and receptor activator of nuclear factor-kappa-Β ligand (RANKL) is contemplated and explored in this review. Studies have proposed various mechanisms of gut microbiome interaction with osteoclastogenesis and bone health, including micro-RNA, insulin-like growth factor 1, and immune system mediation. However, alterations to the gut microbiome secondary to pharmaceutical and surgical interventions cannot be discounted and are discussed in the context of clinical therapeutic consideration. The literature on probiotics and their mechanisms of action is examined in the context of bone healing. The known and hypothesized interactions of common osteoporosis drugs and the human gut microbiome are examined. Since dysbiosis in the gut microbiota can function as a biomarker of bone metabolic activity, it may also be a pharmacological and nutraceutical (i.e., pre- and probiotics) therapeutic target to promote bone homeostasis.

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confidence: 99%

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Seely

Kotelko

Douglas

et al. 2021

IJMS

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Mutagens in commercial food processing and its microbial transformation

Merugu

Manapuram

Chakraborty

et al. 2023

Food Sci Biotechnol

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Mechanistic Development of Cancers Associated with Processed Meat Products: A Review

Bedale,

Milkowski,

Czuprynski

et al. 2023

Meat and Muscle Biology

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Epidemiological data link processed meat products to various cancers, especially colorectal cancer; however,such evidence cannot prove causation. Clear mechanistic evidence of how these foods promote carcinogenesis strengthens the case for causation. Because the complexity and heterogeneity of processed meats as a food category complicate both epidemiological and mechanistic assessments, the study of carcinogenic mechanisms associated with specific components of such foods is often undertaken. These include components that are intrinsic to meats, those that contaminate meat, and those ingredients that are added to or form in meats during processing. Consumption of processed meats also leads to endogenous production of agents, epigenetic changes, and alterations in the microbiota of the digestive tract; therefore,the potential contributions of these endogenous responses to carcinogenesis are also discussed. This review highlights data that illuminate potential mechanisms by which agents associated with processed meats (including processed poultry) could contribute to carcinogenesis. The potential for personal factors such as overall diet, cooking methods, genetic variation, and inflammation and infection status to influence these carcinogenic mechanisms is also summarized. Because the intended audience of this review includes those who may be less familiar with current general mechanisms of mutagenesis and carcinogenesis, detailed background on these topics is provided.

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The potential of bacterial cultures to degrade the mutagen 2-methyl-1,4-dinitro-pyrrole in a processed meat model

Cited by 3 publications

References 33 publications

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

Mutagens in commercial food processing and its microbial transformation

Mechanistic Development of Cancers Associated with Processed Meat Products: A Review

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