The potential of Arum spp. as a cure for hemorrhoids: chemistry, bioactivities, and application

Kozuharova, Ekaterina; Naychov, Zheko; Kochmarov, Vladimir; Benbassat, Niko; Gibernau, Marc; Momekov, Georgi

doi:10.1007/s13596-020-00425-x

Cited by 12 publications

(17 citation statements)

References 52 publications

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“…can be attributed to the presence of raphides, alkaloids and cyanogenic glycosides. 9,39 The present study, in agreement with previous studies demonstrated a reduction in survival rate in CLP-induced sepsis in rats. 26,27,35 The reason of high mortality rates in sepsis is excessive release of cytokines which results in hyper-inflammatory state.…”

Section: Discussionsupporting

confidence: 94%

“…In addition to the therapeutic effects, toxic effects of this plant have also been reported. 9 In the present study, administration of A. orientale extract increased MPO activity which shows pro-inflammatory effect of this extract. Evidences related to pro-inflammatory activities of Arum species is poor.…”

Section: Discussionsupporting

confidence: 57%

“…have detected in different parts of Arum species. [9][10][11] It has been also reported that tubers of A. orientale contain glucomannans (A, B and C). Of these glucomannan B was predominant and mainly composed of D-glucose, D-mannose and traces of uronic acid.…”

Section: Introductionmentioning

confidence: 94%

“…In spite of common use of arum species as herbal remedies, there is few studies regarding their chemical constituents. 9 As far, presence of some valuable phytochemical components such as alkaloids, glycosides (flavonoids, saponin and cyanogenic groups), lectins monoterpenes, polyphenols, sesquiterpenes, etc. have detected in different parts of Arum species.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] It has been also reported that A. palaestinum and A. dioscoridis have antioxidant effects. 9 It is worth to note, A. orientale has not been studied in Iran and only few studies are conducted on this plant hitherto in the world. In the present study, for the first-time phytochemical screening of A. orientale and its possible antibacterial activity and also its effects on hemodynamic parameters, myeloperoxidase (MPO) activity as well as mortality rate were evaluated in cecal ligation and puncture (CLP)-induced sepsis.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Hydroalcoholic Extract ofArum orientaleon CLP-Induced Sepsis in Rats

et al. 2020

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Background: Sepsis is a lethal clinical syndrome that results from dysregulated systemic inflammatory response of the body due to the invasion of pathogens, especially bacteria. Despite advances in medical care and therapy, sepsis is still one of the major causes of death in intensive care units and no decisive medical treatment is available against that. Studies have suggested that some Arum species have anti-bacterial properties. The present study investigated the effects of hydroalcoholic extract of Arum orientale, on cecal ligation and puncture (CLP) induced sepsis in rats. Methods: CLP method was used for induction of sepsis in rats. Hydroalcoholic extract of A. orientale was injected intraperitoneally with doses of 80 and 640 mg/Kg body weight at times of 0, 1, 3, 6 and 24 h after the surgery. Antibacterial activity, hemodynamic parameters, myeloperoxidase (MPO) activity and survival rate were measured after 72 h. Results: Hydroalcoholic extract of A. orientale showed antibacterial activities as potent as gentamycin against Escherichia coli. Administration of the extract with a dose of 80 mg/Kg body weight increased significantly hemodynamic parameters such as mean arterial pressure (p<0.05)and decreased optical density (OD) (p<0.05) of blood. The extract also increased serum MPO activity (p<0.01) and reduced survival rate to 20%. Conclusion: This study for the first time showed that hydroalcoholic extract of A. oriental acts as a double edge sword in the treatment of CLP-induced sepsis. This extract showed antibacterial properties and also improved hemodynamic parameters but decreased survival rate, that might be through pro-inflammatory effects.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Hydroalcoholic Extract ofArum orientaleon CLP-Induced Sepsis in Rats

et al. 2020

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Comprehensive LC‐MS/MS phenolic profiling of Arum elongatum plant and bioaccessibility of phenolics in their infusions

Ozkan,

Sakarya,

Akdas

et al. 2023

eFood

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Arum elongatum has various bioactive compounds including phenolic acids and flavonoids that may have beneficial effects on human health. The main objectives of this study were to determine the phenolic profile of the A. elongatum plant together with the total phenolic (TPC), total flavonoid contents (TFC), and total antioxidant capacities of A. elongatum infusions throughout gastrointestinal digestion. The samples used in the present study were obtained from two cities (C1 and C2) in Türkiye. According to the results, while the primary compounds found in sample C1 were vanillic acid (51.29 ± 2.61 ng/mg), p‐coumaric acid (48.36 ± 2.84 ng/mg) and O‐coumaric acid (156.02 ± 0.67 ng/mg); chlorogenic acid (50.63 ± 0.65 ng/mg), scutellarin (144.34 ± 0.74 ng/mg), and O‐coumaric acid (53.34 ± 0.97 ng/mg) were the major compounds in C2 sample showing the differences between different locations. In addition to these, although both TPC and TFC values for C2 infusion (2960 ± 104 mg GAE/100 g and 397 ± 50 mg CE/100 g, respectively) were found to be higher than the infusion of sample C1, there were no significant differences between the TPC and TFC results after intestinal digestion (p > 0.05). Besides, TPC of the bioaccessible fractions of these two samples didn't show a significant difference (p > 0.05), whereas C1 infusion (202 ± 21%) presented a higher value than the C2 infusion (143 ± 12%) for their bioaccessible TFC value. Our results indicated that A. elongatum infusion may be a potential herbal tea due to its rich phenolic content, making it a suitable substitute for widely used herbal teas.

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Bioactive Compounds and Biological Activities of Arum L.

Kozuharova,

Pasdaran,

Hamedi

et al. 2023

Reference Series in Phytochemistry

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The potential of Arum spp. as a cure for hemorrhoids: chemistry, bioactivities, and application

Cited by 12 publications

References 52 publications

The Effects of Hydroalcoholic Extract ofArum orientaleon CLP-Induced Sepsis in Rats

The Effects of Hydroalcoholic Extract ofArum orientaleon CLP-Induced Sepsis in Rats

Comprehensive LC‐MS/MS phenolic profiling of Arum elongatum plant and bioaccessibility of phenolics in their infusions

Bioactive Compounds and Biological Activities of Arum L.

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