The potential of antifungal peptide Sesquin as natural food preservative

Ramos‐Martín, Francisco; Herrera‐León, Claudia; Antonietti, Viviane; Sonnet, Pascal; Sarazin, Catherine; D’Amelio, Nicola

doi:10.1016/j.biochi.2022.03.015

Cited by 7 publications

(4 citation statements)

References 143 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is negatively charged, there is a charge gradient along the amide protons and this is why this AMP can reach the phosphate group in the membrane. [ 205 ]…”

Section: Sams Inspired By Biomimicrymentioning

confidence: 99%

“…Although it is negatively charged, there is a charge gradient along the amide protons and this is why this AMP can reach the phosphate group in the membrane. [205] Despite the promising properties of AMPs against bacteria, there is still a chance of developing resistance. [206] For example, based on the results acquired from mimicking the MRSA membrane, by increasing the lysylphosphatidyglycerol (LPG) concentration at a low pH (5.5), the overall charge across the membrane is damped by increasing the bilayer order of the membrane.…”

Section: Bactericidal Mechanism Of Ampsmentioning

confidence: 99%

See 1 more Smart Citation

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Liu

Mehrjou

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐resistant bacteria has become another problem in modern medicine. To avoid or reduce the overuse of antibiotics in antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better and smarter than conventional therapies. The common goal of smart antibacterial materials (SAMs) is to increase the antibiotic efficacy or function via an antibacterial mechanism different from that of antibiotics in order to increase the antibacterial and biological properties while reducing the risk of drug resistance. The research and development of SAMs are increasingly interdisciplinary because new designs require the knowledge of different fields and input/collaboration from scientists in different fields. A good understanding of energy conversion in materials, physiological characteristics in cells and bacteria, and bactericidal structures and components in nature are expected to promote the development of SAMs. In this review, the importance of multidisciplinary insights for SAMs is emphasized, and the latest advances in SAMs are categorized and discussed according to the pertinent disciplines including materials science, physiology, and biomimicry.This article is protected by copyright. All rights reserved

show abstract

“…Although it is negatively charged, there is a charge gradient along the amide protons and this is why this AMP can reach the phosphate group in the membrane. [ 205 ]…”

Section: Sams Inspired By Biomimicrymentioning

confidence: 99%

Section: Bactericidal Mechanism Of Ampsmentioning

confidence: 99%

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Liu

Mehrjou

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…The nature of membrane lipids can vary greatly across different organisms leading to tremendous structural diversity: as of 2022, more than 47,000 unique lipid structures have been reported in the LIPID MAPS Structure Database (LSMD) ( Sud et al, 2006 ; Liebisch et al, 2020 ). Despite the great complexity of the plasma membrane composition, only three classes of lipids constitute the vast majority of eukaryotic membranes: glycerolipids (including phospholipids), sphingolipids, and sterols, offering the possibility to prepare simplified models for biophysical studies ( Deleu et al, 2014 ; Ramos-Martín et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study

et al. 2023

Self Cite

View full text Add to dashboard Cite

Introduction: Rhamnolipids (RLs) are secondary metabolites naturally produced by bacteria of the genera Pseudomonas and Burkholderia with biosurfactant properties. A specific interest raised from their potential as biocontrol agents for crop culture protection in regard to direct antifungal and elicitor activities. As for other amphiphilic compounds, a direct interaction with membrane lipids has been suggested as the key feature for the perception and subsequent activity of RLs.Methods: Molecular Dynamics (MD) simulations are used in this work to provide an atomistic description of their interactions with different membranous lipids and focusing on their antifungal properties.Results and discussion: Our results suggest the insertion of RLs into the modelled bilayers just below the plane drawn by lipid phosphate groups, a placement that is effective in promoting significant membrane fluidification of the hydrophobic core. This localization is promoted by the formation of ionic bonds between the carboxylate group of RLs and the amino group of the phosphatidylethanolamine (PE) or phosphatidylserine (PS) headgroups. Moreover, RL acyl chains adhere to the ergosterol structure, forming a significantly higher number of van der Waals contact with respect to what is observed for phospholipid acyl chains. All these interactions might be essential for the membranotropic-driven biological actions of RLs.

show abstract

“…Antimicrobial peptides (AMPs) are promising molecules in the quest for new antibiotics. Produced by several organisms in nature, AMPs are relatively short (10–30 residues) and exhibit a wide range of antimicrobial or immunomodulating activities [ 7 , 8 , 9 ]. In contrast to standard antibiotics, many AMPs are able to quickly permeate cell membranes causing irreversible damage [ 7 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background: SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological properties, its mechanism of action at the molecular level has not been explored. Methods: The structural properties of SAAP-148 and its interaction with phospholipid membranes mimicking mammalian and bacterial cells were studied using liquid and solid-state NMR spectroscopy as well as molecular dynamics simulations. Results: SAAP-148 is partially structured in solution and stabilizes its helical conformation when interacting with DPC micelles. The orientation of the helix within the micelles was defined by paramagnetic relaxation enhancements and found similar to that obtained using solid-state NMR, where the tilt and pitch angles were determined based on 15N chemical shift in oriented models of bacterial membranes (POPE/POPG). Molecular dynamic simulations revealed that SAAP-148 approaches the bacterial membrane by forming salt bridges between lysine and arginine residues and lipid phosphate groups while interacting minimally with mammalian models containing POPC and cholesterol. Conclusions: SAAP-148 stabilizes its helical fold onto bacterial-like membranes, placing its helix axis almost perpendicular to the surface normal, thus probably acting by a carpet-like mechanism on the bacterial membrane rather than forming well-defined pores.

show abstract

The potential of antifungal peptide Sesquin as natural food preservative

Cited by 7 publications

References 143 publications

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study

The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations

Contact Info

Product

Resources

About