“…As a consequence, abnormal expression of SIRT2 is widely believed to be closely related to diverse diseases, such as neurological and metabolic disorders and cancer (Kaya & Eren, 2024;Zhang et al, 2020). Meanwhile, the potential of SIRT2 as a promising intervention has driven researchers to develop SIRT2 inhibitors (Abbotto et al, 2023;Cai et al, 2023;Eren et al, 2019;Gozelle et al, 2022Gozelle et al, , 2023Mellini et al, 2017;Quinti et al, 2016;Rumpf et al, 2015;Spiegelman et al, 2019;Sukuroglu et al, 2021;Tantawy et al, 2021;Trapp et al, 2006;Yagci et al, 2021;Yang et al, 2018Yang et al, , 2019Yang et al, , 2020, most of which have poor isoform selectivity or cellular potency (Kudo et al, 2018).…”