The potential molecular implications of adiponectin in the evolution of SARS-CoV-2: Inbuilt tendency

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Bungău, Simona; Radu, Andrei-Flavius; Batiha, Gaber El‐Saber

doi:10.1016/j.jksus.2022.102347

Cited by 16 publications

(19 citation statements)

References 113 publications

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“…A comprehensive study of the implications of potential biomarkers reported that adiponectin plays essential roles in controlling glucose metabolism, insulin sensitivity, and fatty acid oxidation. Its role in viral infections is linked to its ability to regulate the immune response through its anti-inflammatory or pro-inflammatory axis [ 42 ]. Patients with CKD often have multiple comorbidities, such as hypertension and diabetes, which are also risk factors for severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Mortality, Intensive Care Unit Admission, and Intubation among Hospitalized Patients with COVID-19: A One-Year Retrospective Study in Jordan

Oweidat

Al‐Amer

Saleh

et al. 2023

JCM

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COVID-19 is a public health crisis that has caused numerous deaths, necessitated an increased number of hospital admissions, and led to extended inpatient stays. This study aimed to identify the factors associated with COVID-19 mortality, intensive care unit admission, intubation, and length of hospital stay among Jordanian patients. This was a one-year retrospective study of 745 COVID-19 patients admitted to Jordan University Hospital. Data regarding the patients’ demographics, clinical and co-morbid conditions, imaging, laboratory parameters, mortality, intensive care unit admission (ICU), and intubation were collected from their medical records using a coding manual. The data revealed that the overall rates of COVID-19-related mortality, ICU admission, and invasive intubation were 23.0%, 28.3%, and 10.8%, respectively. Chronic kidney disease (CKD), troponin, lactate dehydrogenase (LDH), and O2 saturation <90% were significantly associated with the mortality rate. The variables that were significantly associated with ICU admission were heart failure and the use of remdesivir. However, O2 saturation <90% and gastrointestinal (GI) symptoms were the only variables associated with invasive intubation. The findings of this study suggest that study-related health outcomes can be used to predict the severity of COVID-19, and they can inform future research aiming to identify specific populations who are at a higher risk of COVID-19 complications.

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Section: Discussionmentioning

confidence: 99%

Mortality, Intensive Care Unit Admission, and Intubation among Hospitalized Patients with COVID-19: A One-Year Retrospective Study in Jordan

Oweidat

Al‐Amer

Saleh

et al. 2023

JCM

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“…In Covid-19, ED (a hallmark of the disease) and activation of adhesion molecules trigger the progression of immunothrombosis and the development of critical complications (Bonaventura et al 2021 ; Al-kuraishy et al 2020a , b). The increasing level of ICAM-1, GDF-15, and YKL-40 is associated with poor clinical outcomes in Covid-19 patients (Babalghith Al-kuraishy et al 2022a , b; Ramadan et al 2022 ; Sharma et al 2020 ).…”

Section: Tirzepatide and Covid-19mentioning

confidence: 99%

“…Cell damage and hyperinflammation are caused by a sequence of inflammatory cellular processes that follow the interaction of SARS-CoV-2 with ACE2. Numerous cellular systems, such as enterocytes, cardiomyocytes, lung alveolar cells, neurons, and testes, express and are dispersed with ACE2 (Al-kuraishy et al 2020a , b; 2022a , b , c ).…”

Section: Introductionmentioning

confidence: 99%

Potential role of tirzepatide towards Covid-19 infection in diabetic patients: a perspective approach

et al. 2023

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In Covid-19, variations in fasting blood glucose are considered a distinct risk element for a bad prognosis and outcome in Covid-19 patients. Tirazepatide (TZT), a dual glucagon-like peptide-1 (GLP-1)and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist may be effective in managing Covid-19-induced hyperglycemia in diabetic and non-diabetic patients. The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight. TZT improves endothelial dysfunction (ED) and associated inflammatory changes through modulation of glucose homeostasis, insulin sensitivity, and pro-inflammatory biomarkers release. TZT, through activation of the GLP-1 receptor, may produce beneficial effects against Covid-19 severity since GLP-1 receptor agonists (GLP-1RAs) have anti-inflammatory and pulmoprotective implications in Covid-19. Therefore, GLP-1RAs could effectively treat severely affected Covid-19 diabetic and non-diabetic patients. Notably, using GLP-1RAs in T2DM patients prevents glucose variability, a common finding in Covid-19 patients. Therefore, GLP-1RAs like TZT could be a therapeutic strategy in T2DM patients with Covid-19 to prevent glucose variability-induced complications. In Covid-19, the inflammatory signaling pathways are highly activated, resulting in hyperinflammation. GLP-1RAs reduce inflammatory biomarkers like IL-6, CRP, and ferritin in Covid-19 patients. Therefore, GLP-1RAs like TZ may be effective in Covid-19 patients by reducing the inflammatory burden. The anti-obesogenic effect of TZT may reduce Covid-19 severity by ameliorating body weight and adiposity. Furthermore, Covid-19 may induce substantial alterations in gut microbiota. GLP-1RA preserves gut microbiota and prevents intestinal dysbiosis. Herein, TZT, like other GLP-1RA, may attenuate Covid-19-induced gut microbiota alterations and, by this mechanism, may mitigate intestinal inflammation and systemic complications in Covid-19 patients with either T2DM or obesity. As opposed to that, glucose-dependent insulinotropic polypeptide (GIP) was reduced in obese and T2DM patients. However, activation of GIP-1R by TZT in T2DM patients improves glucose homeostasis. Thus, TZT, through activation of both GIP and GLP-1, may reduce obesity-mediated inflammation. In Covid-19, GIP response to the meal is impaired, leading to postprandial hyperglycemia and abnormal glucose homeostasis. Therefore, using TZT in severely affected Covid-19 patients may prevent the development of glucose variability and hyperglycemia-induced oxidative stress. Moreover, exaggerated inflammatory disorders in Covid-19 due to the release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α may lead to systemic inflammation and cytokine storm development. Besides, GIP-1 inhibits expression of IL-1β, IL-6, MCP-1, chemokines and TNF-α. Therefore, using GIP-1RA like TZT may inhibit the onset of inflammatory disorders in severely affected Covid-19 patients. In conclusion, TZT, through activation of GLP-1 and GIP receptors, may prevent SARS-CoV-2-induced hyperinflammation and glucose variability in diabetic and non-diabetic patients.

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“…[135] Indeed, Nrf2/HO-1/NQO1 axis is highly activated in the endothelial cells subjected to AGEs activators to provide an adaptive response against OS and/or inflammatory reactions in diabetes. [79,[136][137][138] An experimental study demonstrated that some herbal medicine like Eucommia ulmoides attenuates glucotoxicity by inhibiting AGEs through enhancement of the Nrf2 pathway in diabetic mice. [139] These findings proposed the potential anti-inflammatory effects of Nrf2 through inhibition expression of mTOR, AGEs, NF-κB, and NLRP3 inflammasome.…”

Section: Nrf2 Role In Inflammation and Immune Responsementioning

confidence: 99%

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

Al‐kuraishy,

Al‐Gareeb,

Eldahshan

et al. 2023

J Biochem & Molecular Tox

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COVID‐19 is caused by a novel SARS‐CoV‐2 leading to pulmonary and extra‐pulmonary manifestations due to oxidative stress (OS) development and hyperinflammation. COVID‐19 is primarily asymptomatic though it may cause acute lung injury (ALI), acute respiratory distress syndrome (ARDS), systemic inflammation, and thrombotic events in severe cases. SARS‐CoV‐2‐induced OS triggers the activation of different signaling pathways, which counterbalances this complication. One of these pathways is nuclear factor erythroid 2‐related factor 2 (Nrf2), which induces a series of cellular interactions to mitigate SARS‐CoV‐2‐mediated viral toxicity and OS‐induced cellular injury. Nrf2 pathway inhibits the expression of pro‐inflammatory cytokines and the development of cytokine storm in COVID‐19. Therefore, Nrf2 activators may play an essential role in reducing SARS‐CoV‐2 infection‐induced inflammation by suppressing NLRP3 inflammasome in COVID‐19. Furthermore, Nrf2 activators can attenuate endothelial dysfunction (ED), renin‐angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Thus this mini‐review tries to clarify the possible role of the Nrf2 activators in the management of COVID‐19. Nrf2 activators could be an effective therapeutic strategy in the management of Covid‐19. Preclinical and clinical studies are recommended in this regard.

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The potential molecular implications of adiponectin in the evolution of SARS-CoV-2: Inbuilt tendency

Cited by 16 publications

References 113 publications

Mortality, Intensive Care Unit Admission, and Intubation among Hospitalized Patients with COVID-19: A One-Year Retrospective Study in Jordan

Mortality, Intensive Care Unit Admission, and Intubation among Hospitalized Patients with COVID-19: A One-Year Retrospective Study in Jordan

Potential role of tirzepatide towards Covid-19 infection in diabetic patients: a perspective approach

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

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