The potential mechanism of Guizhi Fuling Wan effect in the treatment of cervical squamous cell carcinoma: A bioinformatics analysis investigation

Wang, Xiaoxiang; Wang, Tianyue; Jiang, Xinyu; Ruan, Yanmin; Wang, Jiamin; Qi, Caixia

doi:10.1097/md.0000000000037153

Cited by 10 publications

(1 citation statement)

References 49 publications

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“…Herbal-derived substances, including essential oils, extractions, or their main constituents, are valuable resources for developing novel antibacterial agents [ 9 – 11 ]. Camphor is a white crystalline solid material with a strong aroma usually obtained from the bark of the Cinnamomum camphora tree through distilling [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Abdollahi,

Fereydouni,

Moradi

et al. 2024

BMC Complement Med Ther

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Herbal components are highly useful assets for the advancement of novel antibacterial drugs. Nanotechnology holds great promise as an approach to enhance the effectiveness and develop the composition of these substances. The study developed nanogels incorporating camphor, thymol, and a combination derived from the initial nanoemulsions with particle sizes of 103, 85, and 135 nm, respectively. The viscosity of nanogels and the successful loading of compounds in them were examined by viscometery and ATR-FTIR studies. The bactericidal properties of the nanogels were examined against four bacterial strains. The nanogel containing camphor and thymol at 1250 µg/mL concentration exhibited complete growth suppression against Pseudomonas aeruginosa and Staphylococcus aureus. The thymol nanogel at 1250 µg/mL and the camphor nanogel at 2500 µg/mL exhibited complete inhibition of growth on Listeria monocytogenes and Escherichia coli, respectively. Both nanogels showed favorable effectiveness as antibacterial agents and could potentially examine a wide range of pathogens and in vivo studies.

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Section: Introductionmentioning

confidence: 99%

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Abdollahi,

Fereydouni,

Moradi

et al. 2024

BMC Complement Med Ther

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Exploration of the sensitization effect of Chaihu Shugan powder on chemotherapy for triple‐negative breast cancer and its active ingredients

Wei,

Li,

2024

Biopolymers

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Chemotherapy plays a crucial role in the clinical treatment of triple‐negative breast cancer (TNBC), but drug resistance limits its clinical application. The active ingredients of Chaihu Shugan Powder (CSP; Bupleurum Liver‐Coursing Powder), quercetin and luteolin, both belong to flavonoid compounds and have significant anti‐tumor potential, which can promote chemotherapy sensitivity. However, the correlation between the two and TNBC paclitaxel (PTX) chemotherapy sensitivity is unknown. We collected herbal components of CSP from the TCMSP database, and screened effective molecules and corresponding targets. STRING database was utilized to construct a protein–protein interaction network combining effective molecules and target genes. The top 50 nodes ranked by affinity were chosen for subsequent functional analysis, and the drug‐active ingredient‐gene interaction network was established using Cytoscape software. Molecular docking was used to determine the small molecules that target TNBC PTX resistance. The “clusterProfiler” package was utilized for GO and KEGG enrichment analyses on the top 50 genes to determine the pathways affected by CSP. Cell counting and colony formation assays evaluated cell viability, IC50 values, and proliferation capacity. Flow cytometry tested PTX intracellular accumulation. Western blot assayed the expression of TNF pathway‐related proteins. Active ingredients of CSP, quercetin and luteolin, could inhibit TNBC cell proliferation and promote PTX chemotherapy sensitization. Quercetin and luteolin repressed the TNF signaling pathway and promoted PTX chemotherapy sensitization. Quercetin and luteolin could inhibit TNBC cell proliferation and promote PTX chemotherapy sensitization through the TNF signaling pathway. Therefore, the use of quercetin and luteolin plus PTX treatment provides a prospective strategy for TNBC treatment.

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Mechanism of Sophorae Flavescentis Radix against ovarian cancer via new pharmacology, molecular docking, and experimental verification

Fu,

Liang

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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The potential mechanism of Guizhi Fuling Wan effect in the treatment of cervical squamous cell carcinoma: A bioinformatics analysis investigation

Cited by 10 publications

References 49 publications

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Exploration of the sensitization effect of Chaihu Shugan powder on chemotherapy for triple‐negative breast cancer and its active ingredients

Mechanism of Sophorae Flavescentis Radix against ovarian cancer via new pharmacology, molecular docking, and experimental verification

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