The potential inflammatory role of arginase and iNOS in children with chronic adenotonsillar hypertrophy

Ünal, Murat; Çimen, Mehmet; Doğruer, Zeynep Nil; Çevik, Tugay

doi:10.1016/j.ijporl.2004.11.003

Cited by 11 publications

(17 citation statements)

References 16 publications

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“…Our previous studies about inflammation and chronic tonsillitis revealed that inflammatory cytokines, reactive oxygen species and L-arginine:Nitric oxide pathway are involved in the development of chronic adeno-tonsillar disease [19][20][21]. The excess amount of these substances may show cytotoxic and genotoxic effects on the oropharyngeal epithelium, and all of them have a role on the development of chronic tissue inflammation and carcinogenesis [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…The excess amount of these substances may show cytotoxic and genotoxic effects on the oropharyngeal epithelium, and all of them have a role on the development of chronic tissue inflammation and carcinogenesis [19][20][21][22]. Also, longterm medication and nutritional factors in children with chronic tonsillitis may have a negative effect on the integrity of the epithelium [23].…”

Section: Discussionmentioning

confidence: 99%

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Cytogenetic biomonitoring in children with chronic tonsillitis: Micronucleus frequency in exfoliated buccal epithelium cells

Ünal

Çelık

Ateş

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cytogenetic biomonitoring in children with chronic tonsillitis: Micronucleus frequency in exfoliated buccal epithelium cells

Ünal

Çelık

Ateş

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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“…The potential inflammatory role of the L-arginine-nitric oxide pathway in the pathogenesis of chronic/recurrent tonsillitis and chronic adenotonsillar hypertrophy has been suggested [7,10]. An extended study to consider patients after the therapy (tonsillectomy) should be the subject of future investigations.…”

Section: Elevated Levels Of Exhaled Nitric Oxide In Recurrent Tonsillmentioning

confidence: 99%

Elevated levels of exhaled nitric oxide in recurrent tonsillitis

Kasperska−Zając¹,

Brzoza²,

Czecior³

et al. 2008

European Respiratory Journal

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“…Recent evidences point towards a role for NO in the development of pharyngeal tonsils or adenoids hypertrophy. Serum arginase and iNOS activities measured in the hemolyzed supernatant fraction of blood erythrocytes were found significantly higher in children with adenotonsillar hypertrophy than in the post‐operative state and in healthy controls . Torretta and colleagues showed that nNO levels from forty‐five children with chronic adenoidal hypertrophy were above the range of normality (721.2 ppb), with 70% of the values superior to 450 ppb .…”

Section: Introductionmentioning

confidence: 98%

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Manna

Montella

Maniscalco³

et al. 2014

Pediatric Pulmonology

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Nitric oxide plays an important role in several physiological and pathophysiological processes in the respiratory tract. Different ways to measure nasal nitric oxide levels in children are currently available. The possibility of obtaining nasal nitric oxide measurement from relatively young children, combined with the availability of portable devices that can be used even in the office setting, opens new perspectives for nasal nitric oxide analysis in the pediatric daily practice. This review presents a synopsis about the current clinical applications of nasal nitric oxide measurement in the pediatric clinical practice. A total of 3,775 articles on the topic were identified, of which 883 duplicates were removed, and 2,803 were excluded based on review of titles and abstracts. Eighty-nine full text articles were assessed for eligibility and 32 additional articles were obtained from the reference lists of the retrieved studies. Since very low nasal nitric oxide levels are found in the majority of patients with primary ciliary dyskinesia, most publications support a central role for nasal nitric oxide to screen the disease, and indicate that it is a very helpful first-line tool in the real-life work-up in all age groups. Decreased nasal nitric oxide concentration is also typical of cystic fibrosis, even though nasal nitric oxide is not as low as in primary ciliary dyskinesia. In other upper airway disorders such as allergic rhinitis, rhinosinusitis, nasal polyposis, and adenoidal hypertrophy, clinical utility of nasal nitric oxide is still critically questioned and remains to be established. Since nNO determination is flow dependent, a general consensus from the major investigators in this area is highly desirable so that future studies will be performed with the same flow rate. A shared nNO methodology will enable to overcome the challenges that lie ahead in incorporating nNO measurement into the mainstream clinical setting of pediatric airway diseases.

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The potential inflammatory role of arginase and iNOS in children with chronic adenotonsillar hypertrophy

Cited by 11 publications

References 16 publications

Cytogenetic biomonitoring in children with chronic tonsillitis: Micronucleus frequency in exfoliated buccal epithelium cells

Cytogenetic biomonitoring in children with chronic tonsillitis: Micronucleus frequency in exfoliated buccal epithelium cells

Elevated levels of exhaled nitric oxide in recurrent tonsillitis

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

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