The potential health benefits of dietary natural plant products in age related eye diseases

Ikonne, Eleazar Uchenna; Ikpeazu, Victor Okezie; Ugbogu, Eziuche Amadike

doi:10.1016/j.heliyon.2020.e04408

Cited by 14 publications

(7 citation statements)

References 133 publications

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“…It neutralizes the oxidative reaction that occurs in photoreceptor cells and upregulates the antioxidant defense system. In particular, some extracts of herbal origin have also shown their capacity to reduce the opacification of the lens and the apoptosis of retinal cells, and are able to inhibit the inflammatory markers of the blood-retinal barrier and improve ocular blood flow [7]. Deficiencies of specific nutrients have been found in patients with glaucoma, and dietary supplementation may play an important role in treatment [61].…”

Section: Discussionmentioning

confidence: 99%

“…This causes oxidative stress, which plays a crucial role in the pathogenesis of age-related eye diseases, by activating nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), and lipid peroxidation. These factors lead to the production of inflammatory cytokines, angiogenesis, protein and DNA damage, and apoptosis [7]. In addition, several other factors can induce glaucoma, such as aging, genetic predisposition, exogenous or endogenous environmental factors [6], increased glutamate levels [8], alteration in nitric oxide (NO) metabolism [9], vascular alterations [10], hypoxia [11], oxidative stress [12], inflammation [13], and apoptosis of glial cells [14].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a New Combination of Natural Extracts on Glaucoma-Related Retinal Degeneration

Molinari

Ruga

Farghali

et al. 2021

Foods

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Background: Glaucoma is currently the leading cause of irreversible blindness; it is a neuropathy characterized by structural alterations of the optic nerve, leading to visual impairments. The aim of this work is to develop a new oral formulation able to counteract the early changes connected to glaucomatous degeneration. The composition is based on gastrodin and vitamin D3 combined with vitamin C, blackcurrant, and lycopene. Methods: Cells and tissues of the retina were used to study biological mechanisms involved in glaucoma, to slow down the progression of the disease. Experiments mimicking the conditions of glaucoma were carried out to examine the etiology of retinal degeneration. Results: Our results show a significant ability to restore glaucoma-induced damage, by counteracting ROS production and promoting cell survival by inhibiting apoptosis. These effects were confirmed by the intracellular mechanism that was activated following administration of the compound, either before or after the glaucoma induction. In particular, the main results were obtained as a preventive action of glaucoma, showing a beneficial action on all selected markers, both on cells and on eyecup preparations. It is therefore possible to hypothesize both the preventive and therapeutic use of this formulation, in the presence of risk factors, and due to its ability to inhibit the apoptotic cycle and to stimulate cell survival mechanisms, respectively. Conclusion: This formulation has exhibited an active role in the prevention or restoration of glaucoma damage for the first time.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of a New Combination of Natural Extracts on Glaucoma-Related Retinal Degeneration

Molinari

Ruga

Farghali

et al. 2021

Foods

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“…Several promising treatments preventively targeting oxidative stress-driven neurodegeneration have emerged in recent years [ 6 ]. Among them, the administration of natural substances by dietary supplementation has been increasingly considered for their potential antioxidant and anti-inflammatory efficacy attained with a low invasiveness [ 7 ]. Several studies have suggested that treatment with protective compounds that inhibit oxidative stress and inflammation could reduce the amount of photoreceptor cell death in animal models of light-induced retinal damage (LD) [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.

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“…The expression of NADPH oxidase subtype NOX2 and inflammatory cytokine TNF-α in retinal tissue is increased at the mRNA level. Elevated intraocular pressure impairs the automatic regulation of retinal arterioles and induces oxidative stress in mice [153][154][155].…”

Section: How Increased Reactive Oxygen Species (Ros) Play a Role In Glaucomamentioning

confidence: 99%

The Relationship between Mitochondria and Neurodegeration in the Eye: A Review

Liu¹,

Liu²,

Prokosch³

2021

Applied Sciences

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Mitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are considered to be neurodegenerative diseases, such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we review the mechanisms of mitochondrial damage, post-injury repair, and the roles of mitochondria in various tissues of the eye. In the following sections, the potential for treating glaucoma by reducing mitochondrial damage and promoting post-injury repair is also discussed.

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The potential health benefits of dietary natural plant products in age related eye diseases

Cited by 14 publications

References 133 publications

Effects of a New Combination of Natural Extracts on Glaucoma-Related Retinal Degeneration

Effects of a New Combination of Natural Extracts on Glaucoma-Related Retinal Degeneration

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

The Relationship between Mitochondria and Neurodegeration in the Eye: A Review

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