The Potential for Targeting AVIL and Other Actin-Binding Proteins in Rhabdomyosarcoma
Robert Cornelison,
Laine Marrah,
Adelaide Fierti
et al.
Abstract:Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue cancer with a survival rate below 27% for high-risk children despite aggressive multi-modal therapeutic interventions. After decades of research, no targeted therapies are currently available. Therapeutically targeting actin-binding proteins, although promising, has historically been challenging. Recent advances have made this possibility more salient, including our lab’s identification of advillin (AVIL), a novel oncogenic actin-binding protein t… Show more
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