The Potential for Proteomics in Understanding Neurodevelopmental Disorders

Wormwood, Kelly L.; Sokolowska, Izabela; Ryan, Jeanne P.; Russell, Stephanie; Darie, Costel C.; Woods, Alisa G.

doi:10.4172/jpb.s5-001

Cited by 4 publications

(3 citation statements)

References 77 publications

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“…sera, plasma, saliva, urine). MS‐based proteomic studies specifically conducted on human biological materials could aid in the search for such biological endpoints .…”

Section: Ms Analysis In Fragile X Syndromementioning

confidence: 99%

Autism spectrum disorder: An omics perspective

Woods

Wormwood

Wetie

et al. 2014

Proteomics Clinical Apps

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Current directions in autism spectrum disorder (ASD) research may require moving beyond genetic analysis alone, based on the complexity of the disorder, heterogeneity and convergence of genetic alterations at the cellular/functional level. Mass spectrometry (MS) has been increasingly used to study CNS disorders, including ASDs. Proteomic research using MS is directed at understanding endogenous protein changes that occur in ASD. This review focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using MS, including fragile X syndrome (FXS) and Smith-Lemli-Opitz Syndrome (SLOS), genetic syndromes highly associated with ASD comorbidity.

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“…sera, plasma, saliva, urine). MS‐based proteomic studies specifically conducted on human biological materials could aid in the search for such biological endpoints .…”

Section: Ms Analysis In Fragile X Syndromementioning

confidence: 99%

Autism spectrum disorder: An omics perspective

Woods

Wormwood

Wetie

et al. 2014

Proteomics Clinical Apps

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“…A recent United States government survey (Centers for Disease Control and Prevention; CDC) of parents indicates that ASD prevalence may even be as high as 1 in 50 [2]. Detection and treatment of ASD is often a focus of parents, educators, healthcare providers, and researchers [3][4][5][6], however greater dialogue on often-overlooked issues, such as bullying and mental health, is greatly needed.…”

Section: Victimizationmentioning

confidence: 99%

Bullying and Autism

Woods¹

2013

Autism

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“…Proteomics is an emerging field that focuses on the study of proteins. The workhorse of proteomic research is largely MS, which can be used to provide unbiased assessment of the protein components of a biological sample [1][2][3][4][5][6][7][8][9]. MS can also be used to study other "omics" such as metabolomics, lipidomics, interactomics, and others.…”

Section: Introductionmentioning

confidence: 99%

Salivary proteomics and biomarkers in neurology and psychiatry

Wormwood

Aslebagh

Channaveerappa

et al. 2015

Proteomics Clinical Apps

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Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective and earlier diagnoses of CNS conditions. Proteomics and other omics MS-based technologies are tools currently being utilized in much recent CNS research. Saliva is an interesting alternative biomaterial for the proteomic study of CNS disorders, with several advantages. Collection is noninvasive and saliva has many proteins. It is easier to collect than blood and can be collected by professionals without formal medical training. For psychiatric and neurological patients, supplying a saliva sample is less anxiety-provoking than providing a blood sample, and is less embarrassing than producing a urine specimen. The use of saliva as a biomaterial has been researched for the diagnosis of and greater understanding of several CNS conditions, including neurodegenerative diseases, autism, and depression. Salivary biomarkers could be used to rule out nonpsychiatric conditions that are often mistaken for psychiatric/neurological conditions, such as fibromyalgia, and potentially to assess cognitive ability in individuals with compromised brain function. As MS and omics technology advances, the sensitivity and utility of assessing CNS conditions using distal human biomaterials such as saliva is becoming increasingly possible.

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The Potential for Proteomics in Understanding Neurodevelopmental Disorders

Cited by 4 publications

References 77 publications

Autism spectrum disorder: An omics perspective

Autism spectrum disorder: An omics perspective

Bullying and Autism

Salivary proteomics and biomarkers in neurology and psychiatry

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