The potential for drug resistance in schistosomiasis

Coles, G.C.; Bruce, J. I.; Kinoti, G. K.; Mutahi, W.T.; Dias, L. C. S.; Rocha, Regina; Katz, Naftale

doi:10.1016/0169-4758(87)90121-9

Cited by 16 publications

(7 citation statements)

References 8 publications

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“…Helminth parasites frequently exhibit intense intrahost competition and selection, a phenomenon known as the ' crowding ' effect (Anderson and May, 1992) equivalent to the GI regulation described above ; their sexual life-cycle means that recombinational loss of resistance gene combinations will occur ; and the mechanisms of drug action and parasite resistance suggest that fitness costs will plausibly be associated with resistance (Wolstenholme et al 2004). Drug resistance is a major concern in human microscopic helminth infections such as schistosomiasis (Coles et al 1987 ;Doenhoff et al 2002 ;Hagan et al 2004) and onchocerciasis (Dadzie, Neira and Hopkins, 2003 ;Awadzi et al 2004). The incorporation of the complex dynamics, identified above, caused by intrahost effects may therefore be usefully incorporated into these discussions and have a wider impact on our understanding of drug resistance in other important human infections.…”

Section: Discussionmentioning

confidence: 99%

Complex dynamics and stability of resistance to antimalarial drugs

Hastings

2006

Parasitology

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A succession of antimalarial drugs has been deployed to treat human falciparum malaria but each has, in turn, been nullified by the spread of drug resistance. The consensus view has always been that, once present, resistance will inevitably rapidly increase to 100 %. However, recent field evidence has shown this is not inevitable, and that drug resistance may initially spread and then stabilize at relatively low frequencies. It is proposed that intense competition between separate malaria clones co-infecting the same human can generate complex dynamics capable of explaining this observation. Standard population genetic analysis confirms this assertion. The dynamics underlying the evolution of antimalarial resistance may therefore be much more complex than previously realized, and can resolve the apparent paradox between field data and the underlying theory of the evolution of resistance. This explanation is novel and the results are equally applicable to other parasitic species where multiple infections of the same host are common.

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Section: Discussionmentioning

confidence: 99%

Complex dynamics and stability of resistance to antimalarial drugs

Hastings

2006

Parasitology

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“…Disease outcomes are not usually detected until overt complications are diagnosed [61,62]. Praziquantel has been the anthelmintic drug of choice for the past 40 years [63,64], although it is not effective against newly developed worms, and cannot prevent re-infection; there are also concerns regarding resistance [65][66][67]. Epiisopilotulorine (1) from the leaves of Pilocarpus microphyllus Stapf.…”

Section: Alkaloids In Drug Discovery For Tropical and Neglected Diseasesmentioning

confidence: 99%

Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs

Daley¹,

Cordell

2021

Molecules

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An overview is presented of the well-established role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs. The necessity for a new international paradigm for natural product discovery and development for the treatment of multidrug resistant organisms, and rare and neglected tropical diseases in the era of the Fourth Industrial Revolution and the Quintuple Helix is discussed.

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“…Furthermore, commercial praziquantel is a racemate, comprising both the R and S isomers yet only the ( R ) isomer is responsible for antischistosomal activity. It has a bitter taste and may contribute to drug non-compliance especially in the mass drug administration programs and, importantly, has been reported to have reduced efficacy in some schistosome strains raising worries of development of resistance [ 178 , 179 , 180 ].…”

Section: Schistosomiasismentioning

confidence: 99%

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

et al. 2016

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Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.

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The potential for drug resistance in schistosomiasis

Cited by 16 publications

References 8 publications

Complex dynamics and stability of resistance to antimalarial drugs

Complex dynamics and stability of resistance to antimalarial drugs

Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

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