The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease

Gomes, Bárbara; Loureiro, Joana A.; Coelho, Manuel A. N.; Pereira, Maria do Carmo

doi:10.2174/1381612821666150130120358

Cited by 7 publications

(6 citation statements)

References 125 publications

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“…Previously, our research group has discussed the potential effect of fluorinated molecules for AD treatment [32]. The current study reveals the powerful role of fluorine for the inhibition of anti-amyloid aggregation and suggests a new therapeutic approach of fluorine in combination with nanotechnology.…”

Section: Introductionmentioning

confidence: 74%

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Dabur

Loureiro

Pereira

2020

IJMS

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Alzheimer’s disease (AD) is a serious health concern, affecting millions of people globally, which leads to cognitive impairment, dementia, and inevitable death. There is still no medically accepted treatment for AD. Developing therapeutic treatments for AD is an overwhelming challenge in the medicinal field, as the exact mechanics underlying its devastating symptoms is still not completely understood. Rather than the unknown mechanism of the disease, one of the limiting factors in developing new drugs for AD is the blood–brain barrier (BBB). A combination of nanotechnology with fluorinated molecules is proposed as a promising therapeutic treatment to meet the desired pharmacokinetic/physiochemical properties for crossing the BBB passage. This paper reviews the research conducted on fluorine-containing compounds and fluorinated nanoparticles (NPs) that have been designed and tested for the inhibition of amyloid-beta (Aβ) peptide aggregation. Additionally, this study summarizes fluorinated molecules and NPs as promising agents and further future work is encouraged to be effective for the treatment of AD.

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Section: Introductionmentioning

confidence: 74%

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Dabur

Loureiro

Pereira

2020

IJMS

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“…Perfluorination could be a tool for subcellular localization of proteins and increase membrane affinity as palmitoylation does [161,162] or to help therapeutic biomolecules and diagnostics permeate the hydrophobic blood-brain barrier. [18,[163][164][165][166] Beyond directing events in cellulo and in vivo, perfluorination could provide exciting opportunities for interfacing biological systems with unnatural hydrophobic materials.…”

Section: Discussionmentioning

confidence: 99%

“…Looking forward, the significant work towards incorporating perfluorinated groups into proteins, peptides, carbohydrates, and lipids should facilitate new tools for manipulating and studying biological systems in research laboratories and in clinical settings. Perfluorination could be a tool for subcellular localization of proteins and increase membrane affinity as palmitoylation does [161,162] or to help therapeutic biomolecules and diagnostics permeate the hydrophobic blood‐brain barrier [18,163–166] . Beyond directing events in cellulo and in vivo, perfluorination could provide exciting opportunities for interfacing biological systems with unnatural hydrophobic materials.…”

Section: Discussionmentioning

confidence: 99%

Perfluorocarbons in Chemical Biology

Miller

Sletten

2020

ChemBioChem

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Perfluorocarbons, saturated carbon chains in which all the hydrogen atoms are replaced with fluorine, form a separate phase from both organic and aqueous solutions. Though perfluorinated compounds are not found in living systems, they can be used to modify biomolecules to confer orthogonal behavior within natural systems, such as improved stability, engineered assembly, and cell-permeability. Perfluorinated groups also provide handles for purification, mass spectrometry, and 19 F NMR studies in complex environments. Herein, we describe how the unique properties of perfluorocarbons have been employed to understand and manipulate biological systems.

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“…Insoluble fibrillar protein aggregates are considered a pathological feature of AD. Several tools have been studied to prevent and treat this disease ( Loureiro et al, 2012 , 2014a ; Gomes et al, 2015 ; Carneiro et al, 2017 ). Therefore, it is indispensable to find drugs that prevent or inhibit the Aβ aggregation ( Ahn et al, 2007 ; Ramalho et al, 2015b ).…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment

et al. 2018

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Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes, mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have been related with its intake, such as anti-carcinogenic, anti-inflammatory and brain protective effects. The neuroprotective effects of RES in neurological diseases, such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, are related to the protection of neurons against oxidative damage and toxicity, and to the prevention of apoptotic neuronal death. In brain cancer, RES induces cell apoptotic death and inhibits angiogenesis and tumor invasion. Despite its great potential as therapeutic agent for the treatment of several diseases, RES exhibits some limitations. It has poor water solubility and it is chemically instable, being degraded by isomerization once exposed to high temperatures, pH changes, UV light, or certain types of enzymes. Thus, RES has low bioavailability, limiting its biological and pharmacological benefits. To overcome these limitations, RES can be delivered by nanocarriers. This field of nanomedicine studies how the drug administration, pharmacokinetics, and pharmacodynamics are affected by the use of nanosized materials. The role of nanotechnology, in the prevention and treatment of neurological diseases, arises from the necessity to mask the physicochemical properties of therapeutic drugs to prolong the half-life and to be able to cross the blood–brain barrier (BBB). This can be achieved by encapsulating the drug in a nanoparticle (NP), which can be made of different kinds of materials. An increasing trend to encapsulate and direct RES to the brain has been observed. RES has been encapsulated in many different types of nanosystems, as liposomes, lipid and polymeric NPs. Furthermore, some of these nanocarriers have been modified with targeting molecules able to recognize the brain areas. Then, this article aims to overview the RES benefits and limitations in the treatment of neurological diseases, as the different nanotechnology strategies to overcome these limitations.

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The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease

Cited by 7 publications

References 125 publications

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Perfluorocarbons in Chemical Biology

Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment

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