The Potential Diagnostic Value of Exosomal Long Noncoding RNAs in Solid Tumors: A Meta-Analysis and Systematic Review

Wu, Zilong; Xu, Zihao; Yu, Bangning; Zhang, Jing tao; Yu, Bentong

doi:10.1155/2020/6786875

Cited by 14 publications

(10 citation statements)

References 72 publications

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“…Silencing the expression of circ_0044516 in PCa cells corroborated with a reduction in growth and metastasis of cancer cells. Similar roles of non-coding RNAs such as exosomal lncRNAs have been described in PCa [ 166 ]. Exosomal lncRNA H19 is known to be upregulated in serum in cases of bladder cancer, thus, having a potential role as a prominent diagnostic marker [ 167 ].…”

Section: Applications Of Tumor Derived Extracellular Vesicles From Li...supporting

confidence: 55%

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

et al. 2022

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Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of isolating tumor-derived entities like circulating tumor cells, circulating tumor DNA, tumor extracellular vesicles, etc., present in the body fluids of patients with cancer, followed by an analysis of genomic and proteomic data contained within them. Methods for isolation and analysis of liquid biopsies have rapidly evolved over the past few years as described in the review, thus providing greater details about tumor characteristics such as tumor progression, tumor staging, heterogeneity, gene mutations, and clonal evolution, etc. Liquid biopsies from cancer patients have opened up newer avenues in detection and continuous monitoring, treatment based on precision medicine, and screening of markers for therapeutic resistance. Though the technology of liquid biopsies is still evolving, its non-invasive nature promises to open new eras in clinical oncology. The purpose of this review is to provide an overview of the current methodologies involved in liquid biopsies and their application in isolating tumor markers for detection, prognosis, and monitoring cancer treatment outcomes.

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Section: Applications Of Tumor Derived Extracellular Vesicles From Li...supporting

confidence: 55%

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

et al. 2022

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“…Higher expression levels of exosomal lncRNA-H19 compared to parental cells have been reported in DOX resistance [ 380 ]. A recent meta-analysis has confirmed that lncRNAs in SEVs could be a promising bioindicator for the diagnosis and prognosis of solid tumors [ 483 ].…”

Section: Exosomes As Relevant Breast Cancer Biological Markersmentioning

confidence: 99%

Extracellular Vesicles in Breast Cancer: From Biology and Function to Clinical Diagnosis and Therapeutic Management

Loric

Denis

Desbène

et al. 2023

IJMS

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Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most commonly diagnosed in females. Although BC mortality has been thoroughly declining over the past decades, there are still considerable differences between women diagnosed with early BC and when metastatic BC is diagnosed. BC treatment choice is widely dependent on precise histological and molecular characterization. However, recurrence or distant metastasis still occurs even with the most recent efficient therapies. Thus, a better understanding of the different factors underlying tumor escape is mainly mandatory. Among the leading candidates is the continuous interplay between tumor cells and their microenvironment, where extracellular vesicles play a significant role. Among extracellular vesicles, smaller ones, also called exosomes, can carry biomolecules, such as lipids, proteins, and nucleic acids, and generate signal transmission through an intercellular transfer of their content. This mechanism allows tumor cells to recruit and modify the adjacent and systemic microenvironment to support further invasion and dissemination. By reciprocity, stromal cells can also use exosomes to profoundly modify tumor cell behavior. This review intends to cover the most recent literature on the role of extracellular vesicle production in normal and cancerous breast tissues. Specific attention is paid to the use of extracellular vesicles for early BC diagnosis, follow-up, and prognosis because exosomes are actually under the spotlight of researchers as a high-potential source of liquid biopsies. Extracellular vesicles in BC treatment as new targets for therapy or efficient nanovectors to drive drug delivery are also summarized.

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“…Elevated concentrations of specific circRNAs in exosomes correlate with the presence of ovarian, prostate, and lung cancers (Wang Y. et al, 2019). In addition to miRNAs and circRNAs, other non-coding RNAs, such as lncRNAs in exosomes also play an important role in the diagnosis and monitoring of tumors (Wu et al, 2020). Recent studies have suggested that exosomal lncRNA-GC1 can be used as noninvasive biomarkers in the early detection of gastric cancer and in monitoring its progression (Guo et al, 2020).…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Advances in early detection methods for solid tumors

et al. 2023

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During the last decade, non-invasive methods such as liquid biopsy have slowly replaced traditional imaging and invasive pathological methods used to diagnose and monitor cancer. Improvements in the available detection methods have enabled the early screening and diagnosis of solid tumors. In addition, advances in early detection methods have made the continuous monitoring of tumor progression using repeat sampling possible. Previously, the focus of liquid biopsy techniques included the following: 1) the isolation of circulating tumor cells, circulating tumor DNA, and extracellular tumor vesicles from solid tumor cells in the patient’s blood; in addition to 2) analyzing genomic and proteomic data contained within the isolates. Recently, there has been a rapid devolvement in the techniques used to isolate and analyze molecular markers. This rapid evolvement in detection techniques improves their accuracy, especially when few samples are available. In addition, there is a tremendous expansion in the acquisition of samples and targets for testing; solid tumors can be detected from blood and other body fluids. Test objects have also expanded from samples taken directly from cancer to include indirect objects affected in cancer development. Liquid biopsy technology has limitations. Even so, this detection technique is the key to a new phase of oncogenetics. This review aims to provide an overview of the current advances in liquid biopsy marker selection, isolation, and detection methods for solid tumors. The advantages and disadvantages of liquid biopsy technology will also be explored.

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The Potential Diagnostic Value of Exosomal Long Noncoding RNAs in Solid Tumors: A Meta-Analysis and Systematic Review

Cited by 14 publications

References 72 publications

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

Extracellular Vesicles in Breast Cancer: From Biology and Function to Clinical Diagnosis and Therapeutic Management

Advances in early detection methods for solid tumors

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