The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application

Köseoğlu, Aygül; Al‐Taie, Anmar

doi:10.1016/j.clnesp.2022.09.017

Cited by 5 publications

(3 citation statements)

References 52 publications

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“…The therapeutic value of apples has been described previously, and it is related to polyphenolic content, of which effects have been found in the absorption of gastric secretions, control of intestinal biota, elimination of toxins, and diuretic effect. It can even be interpreted that several of the molecules present may have a regulatory effect on neuronal and metabolic activity [ 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 ]. The secondary metabolites in fruit, such as polyphenols and anthocyanins, have a high antioxidant capacity and have been described for several years; they are often better than the vitamins they contain [ 216 ].…”

Section: Foods With Antioxidant Activitiesmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

et al. 2023

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Food is our daily companion, performing numerous beneficial functions for our bodies. Many of them can help to alleviate or prevent ailments and diseases. In this review, an extensive bibliographic search is conducted in various databases to update information on unprocessed foods with anti-inflammatory and antioxidant properties that can aid in treating diseases such as cancer. The current state of knowledge on inflammatory processes involving some interleukins and tumor necrosis factor-alpha (TNF-α) is reviewed. As well as unprocessed foods, which may help reduce inflammation and oxidative stress, both of which are important factors in cancer development. Many studies are still needed to take full advantage of the food products we use daily.

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Section: Foods With Antioxidant Activitiesmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

et al. 2023

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“…Several scientific works have reported that apple-derived polyphenols are a rich source of nutraceutical biomolecules with beneficial effects on human health. Most of these compounds are polyphenols with antioxidant activity [ 14 , 52 , 53 , 54 ], while some of them also exhibit antiproliferative action [ 33 , 53 ] and can modulate some of the key enzymes implicated in oxidative stress [ 32 ]. In this framework, the neuroprotective properties of the polyphenol-containing Peaks 2–4 ( Figure 4 , Figure 5 and Figure 6 ) may be correlated with the most represented polyphenol components, such as gallic acid, (+)-catechin, chlorogenic acid, caffeic acid, (–)-epicatechin, coumaric acid, and quercetin ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Annurca Apple Flesh Polyphenol Extract

D’Errico,

Nasso,

Di Maro

et al. 2024

Nutrients

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Background: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (AChE, BuChE) or monoamine oxidases (MAO)-A/B, and of Aβ 1–40 aggregation. Diet plant components with multitarget functions are promising compounds in the prevention of AD and PD. Our aim was to identify neuroprotective compounds from Annurca apple polyphenol extract (AFPE). Methods: AFPE was fractionated by gel filtration, and the eluted peaks were subjected to chemical analyses (i.e., RP-HPLC and mass spectrometry), determination of inhibitory enzyme activity and cell effects by MTT, and morphology assays. Results: In AFPE, we identified thaumatin-like protein 1a, belonging to the pathogenesis-related protein (PR) family. This protein showed the best inhibitory activity on AChE, MAO-A (IC50 = 5.53 µM and 1.71 µM, respectively), and Aβ1–40 fibril aggregation (IC50 = 9.16 µM), compared to AFPE and other polyphenol-containing fractions. Among the latter, Peak 4 reverted Aβ fibril formation (IC50 = 104.87 µM). Moreover, thaumatin-like protein 1a protected AGS and MKN-28 cells from serum-deprivation-induced stress conditions. Conclusions: We showed that AFPE exerted neuroprotective functions not only through its polyphenols but also through thaumatin-like protein 1a, which acted like a multitarget molecule.

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“…Colon cancer is one of the most common diseases in the world. The prevention of this disease is important and could lead to a potential lower rate of mortality [63]. Researchers are trying to find the evidence for natural compounds that can be helpful in lowering the risk of developing colon cancer.…”

Section: Beneficial Effects In the Colonmentioning

confidence: 99%

Phenolic Compounds from Apples: From Natural Fruits to the Beneficial Effects in the Digestive System

Jakobek,

Matić

2024

Molecules

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Conditions in the gastrointestinal tract and microbial metabolism lead to biotransformation of parent, native phenolic compounds from apples into different chemical forms. The aim of this work was to review current knowledge about the forms of phenolic compounds from apples in the gastrointestinal tract and to connect it to their potential beneficial effects, including the mitigation of health problems of the digestive tract. Phenolic compounds from apples are found in the gastrointestinal tract in a variety of forms: native (flavan-3-ols, phenolic acids, flavonols, dihydrochalcones, and anthocyanins), degradation products, various metabolites, and catabolites. Native forms can show beneficial effects in the stomach and small intestine and during the beginning phase of digestion in the colon. Different products of degradation and phase II metabolites can be found in the small intestine and colon, while catabolites might be important for bioactivities in the colon. Most studies connect beneficial effects for different described health problems to the whole apple or to the amount of all phenolic compounds from apples. This expresses the influence of all native polyphenols from apples on beneficial effects. However, further studies of the peculiar compounds resulting from native phenols and their effects on the various parts of the digestive tract could provide a better understanding of the specific derivatives with bioactivity in humans.

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The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application

Cited by 5 publications

References 52 publications

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Annurca Apple Flesh Polyphenol Extract

Phenolic Compounds from Apples: From Natural Fruits to the Beneficial Effects in the Digestive System

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