The Potential Beneficial Effect of EPA and DHA Supplementation Managing Cytokine Storm in Coronavirus Disease

Szabó, Zoltán; Marosvölgyi, Tamás; Szabó, Éva; Bai, Péter; Figler, Mária; Verzár, Zsófia

doi:10.3389/fphys.2020.00752

Cited by 43 publications

(37 citation statements)

References 39 publications

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“… 183 , 184 Omega-3 fatty acids are made up of eicosapentaenoic and docosahexaenoic acids, which extensively enhance an immune response to viral infections. 140 , 180 The conversion of Omega-3 by lipoxygenase to lipids mediators such as lipoxins, resolvins, and protectins facilitates a dual role of promoting pro-resolution of inflammation and anti-inflammation. 183 The programmed resolution of acute inflammation reduces neutrophils’ infiltration, increases the recruitment of monocytes, and activates the macrophages to consume dead neutrophils.…”

Section: Mitigation and Therapeutic Intervention Of Covid-19-induced mentioning

confidence: 99%

Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications

Rowaiye¹,

Okpalefe²,

Adejoke³

et al. 2021

JIR

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The COVID-19 pandemic constitutes an arduous global health challenge, and the increasing number of fatalities calls for the speedy pursuit of a remedy. This review emphasizes the changing aspects of the COVID-19 disease, featuring the cytokine storm’s pathological processes. Furthermore, we briefly reviewed potential therapeutic agents that may modulate and alleviate cytokine storms. The literature exploration was made using PubMed, Embase, MEDLINE, Google scholar, and China National Knowledge Infrastructure databases to retrieve the most recent literature on the etiology, diagnostic markers, and the possible prophylactic and therapeutic options for the management of cytokine storm in patients hospitalized with COVID-19 disease. The causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), continually threatens the efficiency of the immune system of the infected individuals. As the first responder, the innate immune system provides primary protection against COVID-19, affecting the disease’s progression, clinical outcome, and prognosis. Evidence suggests that the fatalities associated with COVID-19 are primarily due to hyper-inflammation and an aberrant immune function. Accordingly, the magnitude of the release of pro-inflammatory cytokines such as interleukin (IL)-1, (IL-6), and tumor necrosis alpha (TNF-α) significantly differentiate between mild and severe cases of COVID-19. The early prediction of a cytokine storm is made possible by several serum chemistry and hematological markers. The prompt use of these markers for diagnosis and the aggressive prevention and management of a cytokine release syndrome is critical in determining the level of morbidity and fatality associated with COVID-19. The prophylaxis and the rapid treatment of cytokine storm by clinicians will significantly enhance the fight against the dreaded COVID-19 disease.

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Section: Mitigation and Therapeutic Intervention Of Covid-19-induced mentioning

confidence: 99%

Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications

Rowaiye¹,

Okpalefe²,

Adejoke³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…Szabo et al. have stressed upon the supplementation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in COVID-19 patients as both a supportive therapy and a prevention strategy as it appears to have a potential beneficial effect in managing the cytokine storm [ 19 ].…”

mentioning

confidence: 99%

Covid and cholesterol (C&C): Something to worry about or much ado about nothing?

Garg

Khanna

2021

Trends in Anaesthesia and Critical Care

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“…The anti-inflammatory and immunomodulatory effects of PUFAs could affect COVID-19 progression and disease severity [ 29 ]. In fact, it has been reported that high doses of both DHA and EPA may decrease both IL-6 and IL-1β [ 30 ], proteins that play a central role in cytokine storms induced by COVID-19 [ 31 ].…”

Section: Diet and Protective Substancesmentioning

confidence: 99%

Dietary and Protective Factors to Halt or Mitigate Progression of Autoimmunity, COVID-19 and Its Associated Metabolic Diseases

Ricordi

Pacifici

Lanzoni

et al. 2021

IJMS

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COVID-19 is without any doubt the worst pandemic we have faced since the H1N1 virus outbreak. Even if vaccination against SARS-CoV-2 infection is becoming increasingly available, a more feasible approach for COVID-19 prevention and therapy is still needed. Evidence of a pathological link between metabolic diseases and severe forms of COVID-19 has stimulated critical reflection and new considerations. In particular, an abnormal immune response observed in certain patients with SARS-CoV-2 infection suggested possible common predisposing risk factors with autoimmune diseases such as Type 1 Diabetes (T1D). Correct supplementation with dietary factors may be key to preventing and counteracting both the underlying metabolic impairment and the complications of COVID-19. A set of agents may inhibit the cytokine storm and hypercoagulability that characterize severe COVID-19 infection: vitamin D3, omega-3 polyunsaturated fatty acids, polyphenols like pterostilbene, polydatin and honokiol, which can activate anti-inflammatory and antioxidant sirtuins pathways, quercetin, vitamin C, zinc, melatonin, lactoferrin and glutathione. These agents could be highly beneficial for subjects who have altered immune responses. In this review, we discuss the antiviral and metabolic effects of these dietary factors and propose their combination for potential applications in the prevention and treatment of COVID-19. Rigorous studies will be fundamental for validating preventive and therapeutic protocols that could be of assistance to mitigate disease progression following SARS-CoV-2 infection.

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The Potential Beneficial Effect of EPA and DHA Supplementation Managing Cytokine Storm in Coronavirus Disease

Cited by 43 publications

References 39 publications

Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications

Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications

Covid and cholesterol (C&C): Something to worry about or much ado about nothing?

Dietary and Protective Factors to Halt or Mitigate Progression of Autoimmunity, COVID-19 and Its Associated Metabolic Diseases

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