The potential anti-inflammatory benefits of improving physical fitness in hypertension

Edwards, Kate M.; Mills, Paul J.

doi:10.1097/hjh.0b013e328165ca67

Cited by 34 publications

(32 citation statements)

References 149 publications

(160 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Subsequently, besides the hallmark neuropathology associated with AD chronic low-grade inflammation is also considered a hallmark of AD that may be influencing the neurodegenerative progression of the disease (Wyss-Coray, 2006; Swardfager et al, 2010). Similarly, chronic low-grade inflammation is recognized as a hallmark of hypertension and is attributed, in part, to the etiology of vascular disease (Boos and Lip, 2006; Edwards et al, 2007). …”

Section: Pro-inflammatory Markers Systemic Inflammation and Cytokinementioning

confidence: 99%

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

Hess

Smart

2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%–15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors (VRF’s) are considered high risk candidates for developing cognitive impairment in later life. Evidence suggests that vascular injury resulting from untreated VRF’s promotes progression from MCI to AD and exacerbates the severity of dementia in AD, and neuroimaging studies have found that the neurodegenerative processes associated with AD are heavily driven by VRF’s that promote cerebral hypoperfusion. Subsequently, common links between vascular disorders such as hypertension and neurodegenerative disorders such as AD include compromised vasculature, cerebral hypoperfusion and chronic low grade inflammation (a hallmark of both hypertension and AD). Exercise has been demonstrated to be an effective intervention for blood pressure management, chronic low grade inflammation and improvements in cognition. Data from recent analyses suggests that isometric exercise training (IET) may improve vascular integrity and elicit blood pressure reductions in hypertensives greater than those seen with dynamic aerobic and resistance exercise. IET may also play an effective role in the management of VRF’s at the MCI stage of AD and may prove to be a significant strategy in the prevention, attenuation or delay of progression to AD. A plausible hypothesis is that the reactive hyperemia stimulated by IET initiates a cascade of vascular, neurotrophic and neuro-endocrine events that lead to improvements in cognitive function.

show abstract

Section: Pro-inflammatory Markers Systemic Inflammation and Cytokinementioning

confidence: 99%

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

Hess

Smart

2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Hence, the activation of PPARα and downstream gene expression by exercise very likely constitutes a significant aspect of the cardiometabolic effects of physical activity. Similarly, PPARα is present in the vascular endothelium and smooth muscle, where it modulates endothelial responses and levels of inflammatory mediators in conjunction with exercise (26). Therefore, to the extent that we and others have observed associations between genetic variation in PPARA and individual differences in metabolic risk factors, it follows that this same genetic variation may influence the degree to which exercise mitigates the toxic cardiometabolic and vascular effects of excess adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

PPARα gene polymorphisms modulate the association between physical activity and cardiometabolic risk

Halder

Champlin

Sheu

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Background and Aims Habitual physical activity is understood to help prevent type 2 diabetes and atherosclerotic cardiovascular disease via beneficial effects on both metabolism and the vascular system. However, individuals do not have uniform cardiometabolic responses to physical activity. Here we explore the extent to which variation in the proliferator-activated receptor-alpha (PPARA) gene, which modulates carbohydrate and lipid metabolism, vascular function, and inflammation, predicts the overall cardiometabolic risk (CMR) profile of individuals engaging in various levels of physical activity. Methods and results 917 unrelated, community volunteers (52% female, of Non-Hispanic European ancestry) aged 30–54 years, participated in the cross-sectional study. Subjects were genotyped for 5 single nucleotide polymorphisms in the PPARA gene, from which common haplotypes were defined. A continuous measure of CMR was calculated as an aggregate of 5 traditional risk factors: waist circumference, resting blood pressure, fasting serum triglycerides, HDL-cholesterol and glucose. Regression models were used to examine the main and interactive effects of physical activity and genetic variation on CMR. One common PPARA haplotype (H-23) was associated with a higher CMR. This association was moderated by daily physical activity (B= −0.11, SE=0.053, t=−2.05, P=0.04). Increased physical activity was associated with a steeper reduction of CMR in persons carrying the otherwise detrimental H-23 haplotype. Conclusions Variations in the PPARA gene appear to magnify the cardiometabolic benefits of habitual physical activity.

show abstract

“…Aerobic exercise reduces blood demand at the same exercise intensity, and decreases BP and myocardial VO 2 . In addition, VO 2 max increases as the VO 2 of peripheral tissues increases efficiently [31]. Moreover, after phase 2 is completed, patients in the CR group will typically adopt continuous exercise habits.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hospital-based Cardiac Rehabilitation on Quality of Life and Physical Capacity in Acute Myocardial Infarction Patients: 2 Years Follow Up

Kim¹,

Nam²,

Oh³

et al. 2018

J Clin Exp Cardiolog

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the effect of hospital-based cardiac rehabilitation (CR) on quality of life (QOL) and physical functions in patients with acute myocardial infarction (AMI) during 2 years of followup.Methods: All AMI patients referred to the Cardiac Health and Rehabilitation Center (CHRC) were informed about CR and followed for 2 years on an outpatient basis from July 2010 to December 2015. Patients who were divided into a CR group and non-CR group. All patients took home-based self-exercise as CR programs of CHRC and in addition, the CR group received hospital-based supervised exercise training three times a week for 2 months. Both groups were evaluated for physical capacity and QOL at baseline, after 2 months of exercise training, and at 6 months, 1 year, and 2 years of follow-up. Results:The CR group showed significant improvements in physical functioning (PF), physical role functioning, bodily pain, vitality (VT), social role functioning, emotional role functioning, mental health, physical component summary (PCS), and mental component summary at all-time points compared to baseline. At 1 year of follow-up, the CR group displayed significantly greater PF, general health perceptions, VT, and PCS values than the non-CR group. Regarding physical capacity, the CR group exhibited significantly lower resting heart rate and significantly greater maximal oxygen consumption and metabolic equivalents than the non-CR group at 6 months of follow-up. Conclusion:Hospital-based CR was effective in promoting QOL and early improvement in exercise capacity in patients with AMI. Further, the improvement in QOL was maintained for up to 2 years.

show abstract

The potential anti-inflammatory benefits of improving physical fitness in hypertension

Cited by 34 publications

References 149 publications

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer’s Disease

PPARα gene polymorphisms modulate the association between physical activity and cardiometabolic risk

Effect of Hospital-based Cardiac Rehabilitation on Quality of Life and Physical Capacity in Acute Myocardial Infarction Patients: 2 Years Follow Up

Contact Info

Product

Resources

About