The Potential Anti Helicobacter pylori and antioxidant effects of Artemisia Judaica

Abstract

Artemisia judaica (AJ) is one of the common species of the genus Artemisia that grows in Saudi Arabia desert and Sinai, Egypt where animals graze on it. It is widely used in traditional medicine and by Bedouins there. (AJ) has anthelmintic, antibacterial, antiinflammatory, analgesic and antipyretic effects. The present study aimed to (1) elucidates the antibacterial action of AJ against H. pylori and different other bacterial species (2) delineate the potential antibacterial mechanism of action of AJ in comparison with tetracycline and cefotaxime (3) measure the trolox equivalent antioxidant capacity (TEAC) of the AJ water extract. Preparation of the (AJ) extracts was done by three different methods two of them are usually performed by population in Middle East by boiling of the shade-dried herb in water as tea (decoction), or soaked in tap water for over night (infusion), other method was done by concentrating the aqueous extract of Artemisia judaica under vacuum. The results of this study revealed that (AJ) has neither antibacterial effects either against H. pylori nor any other bacterial species. On the other hand the extract of AJ prepared by any of the above mentioned methods shows significant (p<0.005) antioxidant action as compared with blank and related to trolox antioxidant capacity.

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

“…The natural antioxidants act as a shelter against the offensives of free radicals that can induce harms to the cell [33]. A. judaica, one of the widespread species of the genus Artemisia, is a desert medicinal plant usually used as tea by population in Egypt Sinai [34]. In the traditional medicine of the Arabic area; A. judaica was used to treat skin disorders, weak immune system and gastrointestinal disorders and also to decrease the risk of cancer [35,36].…”

Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan

“…Interestingly, in other traditional medicines of the Arabic region, A. judaica is also used to treat gastrointestinal disorders, and to enhance eyesight, for cardiovascular health, capillary strength and improving the structure of connective tissue, appearance of skin, and the immune system, while promoting decreased risk of atherosclerosis, cancer and arthritis (Khafagy et al, 1988;Janaćković et al, 2015). Furthermore, it is reported that A. judaica has been used in traditional medicine of Bedouins in the Saudi Arabia desert and Sinai, Egypt as a herbal remedy with anthelmintic, antibacterial, anti-inflammatory, and analgesic activities (El-Sayed et al, 2013). It also relieves snake stings, scorpion bites, ear infections, dysentery, coughing and external wounding (Friedjung, 2010).…”

“…Also, water extract of A. judaica sourced from Saudi Arabia showed stronger antioxidant action than trolox (El-Sayed et al, 2013).…”

Comparative chemical study and antimicrobial activity of essential oils of three Artemisia species from Egypt and Saudi Arabia

“…Artemisia judaica L. (‘shih balady’ in Arabic), considered a herbal medicine in Egypt, is characterized by the presence of comparatively high percentages of piperitone and camphor . Anti‐inflammatory, antioxidant, antimicrobial, anti‐helicobacter, anti‐helmintic, anti‐pyretic, and analgesic properties have been reported for EOs derived from A. judaica . Artemisia monosperma is widespread in desert plains and wadis, and its leaves are widely used in Egypt and Saudi Arabia in folk medicine .…”

“…12 Anti-inflammatory, antioxidant, antimicrobial, anti-helicobacter, anti-helmintic, anti-pyretic, and analgesic properties have been reported for EOs derived from A. judaica. [12][13][14][15][16] Artemisia monosperma is widespread in desert plains and wadis, and its leaves are widely used in Egypt and Saudi Arabia in folk medicine. 2 It demonstrates antibacterial activity against Streptococcus agalactiae with a stronger inhibition than recorded for ampicillin.…”